Фармакология

doi: 10.25005/2074-0581-2019-21-4-643-654
СРАВНИТЕЛЬНАЯ ХАРАКТЕРИСТИКА АНТИБАКТЕРИАЛЬНОЙ АКТИВНОСТИ НЕКОТОРЫХ РАСТЕНИЙ, ПРОИЗРАСТАЮЩИХ В ЦЕНТРАЛЬНОЙ ЧАСТИ РЕСПУБЛИКИ ТАДЖИКИСТАН

С. Саторов1, Ф. Мирзоева1, Ш. Саторов2, М. Вахидова2, В. Душенков3

1Кафедра микробиологии, иммунологии и вирусологии, Таджикский государственный медицинский университет им. Абуали ибни Сино, Душанбе, Республика Таджикистан
2Кафедра биологии растений, Школа экологических и биологических наук, Ратгерский Университет, Нью Брансвик, США
3Кафедра естественных наук, Хостоский общественный колледж, Городской Университет Нью-Йорка, Нью-Йорк, США

Цель: Оценить спектр антибактериальной активности некоторых растений, произрастающих в центральной части Республики Таджикистан.

Материал и методы: изучены антибактериальные свойства 18 видов растений из 14 семейств. Из растительных препаратов были выделены экстракты, которыми пропитывались стекловатные диски, затем высушенные диски накладывались на поверхность питательной среды, предварительно засеянной культурой микроба. После инкубации по зоне подавления роста микроорганизмов изучалась активность экстрактов растений относительно микроорганизмов. Антимикробная активность растительных экстрактов определялась диско-диффузионным методом с использованием четырёх видов патогенных стандартных музейных штаммов – Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, – а также с применением этих же видов микроорганизмов, изолированных от стационарных больных.

Результаты: экстракт из листьев A. absinthium обладает широким противомикробным действием против как музейных, так и изолированных госпитальных штаммов S. aureus, P. aeruginosa и E. coli. Экстракт из Morus nigra также продемонстрировал широкую антимикробную активность, однако несколько меньшую, чем A. absinthium. Протестированные экстракты были менее активны в отношении E. coli. Ни один из используемых 18 экстрактов не проявлял активности по отношению к K. pneumoniae

Заключение: широким противомикробным действием характеризовались экстракты Artemisia absinthium и Morus nigra и отличились между собой лишь по степени активности. Несколько узким спектром действия характеризовались экстракты Amarantus tricolor, Arctium tomentosum, Indigofera tinctoria, Punica granatum. Экстракты Mentha arvensis и Allium suworowii имели примерно одинаковую степень ингибирующей способности.

Ключевые слова: растения, ингибирование роста, экстракты, госпитальные штаммы бактерий, референсные штаммы бактерий.

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Сведения об авторах:


Саторов Саидбег
доктор медицинских наук, профессор кафедры микробиологии, иммунологии и вирусологии, Таджикский государственный медицинский университет им. Абуали ибни Сино
SCOPUS: 10419425154
Researcher ID: S-9073-2016
ORCID ID: 0000-0003-1101-1840
Author ID: 78634
SPIN код: 2523-8682
E-mail: sattorion@mail.ru

Мирзоева Фазила
ассистент кафедры микробиологии, иммунологии и вирусологии, Таджикский государственный медицинский университет им. Абуали ибни Сино
ORCID ID: 0000-0003-0187-0334
E-mail: fazila.mirzoeva88@mail.ru

Саторов Шухрат
стажёр кафедры биологии растений, Школа экологических и биологических наук, Ратгерский Университет
SCOPUS: 1742026179
ORCID ID: 0000-0003- 3072-1135
E-mail: sufion@mail.ru

Вахидова Манижа
стажёр кафедры биологии растений, Школа экологических и биологических наук, Ратгерский Университет
ORCID ID: 0000-0002-3366-1580
SPIN код: 9366-9702
E-mail: sufion@mail.ru

Душенков Вячеслав
доктор медицинских наук, профессор кафедры естественных наук, Хостоский общественный колледж, Городской Университет Нью-Йорка
SCOPUS: 6507356097
Researcher ID: AAE-8520-2019
ORCID ID: 0000-0001- 5176-7461
Author ID: 638952
SPIN код: 50533-0988
E-mail: dushenkov@sebs.rutgers.edu

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Саторов Саидбег
доктор медицинских наук, профессор кафедры микробиологии, иммунологии и вирусологии, Таджикский государственный медицинский университет им. Абуали ибни Сино

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