Literature Reviews

doi: 10.25005/2074-0581-2017-19-3-393-398
NON-ALCOHOLIC FATTY LIVER DISEASE: MODERN ASPECTS OF ETIOPATHOGENESIS AND TREATMENT

N.V. Efimenko1, T.I. Ledovskaya2, Т.Е. Fyodorova1, Z.A. Vakhaeva3, A.S. Kaysinova1

1Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
2Federal State Budgetary Institution «Volgograd Medical Clinical Center» of the Federal Medical-Biological Agency, Volgograd, Russia
3LLC “Diagnosticum”, Grozny, Russia

In modern gastroenterology, non-alcoholic fatty liver disease (NAFLD) occupies a special place, in the pathogenesis of which the two stages of development are distinguished («two-hit model»): I hit – is the development of steatosis, based on insulin resistance, and II hit – the transition of steatosis to steatohepatitis caused by course of oxidative stress. Recent studies indicate a significant role in the development of NAFLD adipocytokines and inflammatory mediators (leptin, tumour necrosis factor-α, adiponectin, interleukins, etc.), which contribute to increased insulin resistance, and also support the inflammatory response and stimulate fibrogenesis. In the medical rehabilitation of NAFLD, along with drug therapy, non-drug methods are widely used, in particular, the use of drinking mineral waters inside and outside, which contribute to the activation of the basic bioregulatory systems of the body.

Keywords: Non-alcoholic fatty liver disease, insulin resistance, oxidative stress, health-resort therapy.

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Authors informations:

Efimenko Natalia Viktorovna, Doctor of Medical Sciences, Full Professor, Director of Pyatigorsk State Scientific Research Institute of Balneology

Ledovskaya Tatyana Ivanovna, Candidate of Medical Sciences, Director of the Volgograd Medical Clinical Center

Fyodorova Tatyana Evgenievna, Candidate of Medical Sciences, Leading Researcher of the Scientific Department of the Restorative Gastroenterology of Essentuki Branch of the Pyatigorsk State Scientific Research Institute of Balneology

Vakhaeva Zarema Adamovna, Physician Therapist of the LLC «Diagnosticum»

Kaysinova Agnessa Sardoevna, Doctor of Medical Sciences, Deputy Director for Curative Work, Pyatigorsk State Scientific Research Institute of Balneology

Address for correspondence:

Kaysinova Agnessa Sardoevna

Doctor of Medical Sciences, Deputy Director for Curative Work of Pyatigorsk State Scientific Research Institute of Balneology

357500, Russian Federation, Pyatigorsk, Kirova ave., 30

Tel: (+7) 8793 335766

E-mail: orgotdel@gniik.ru