Literature Reviews

doi: 10.25005/2074-0581-2020-22-1-127-133
AVICENNA’S INFORMATION ABOUT THE HEALING PROPERTIES OF BLACK SEED

Yu.N. Nuraliev1, R.A. Rakhmonov2, M.T. Ganieva2, L.Yu. Nuraliev3

1Institute of Avicenna’s Medicine and Pharmacology, Dushanbe, Republic of Tajikistan
2Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
3Central Scientific Research Laboratory, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

The end of the 20th and the beginning of the 21st centuries in modern medicine can be called the era of the second birth and large-scale phytochemical and pharmacological study of black seed (Nigella sativa L. ). Today, the experience of the famous doctor and encyclopedist Avicenna on the clinical use of herbal medicines, created on the basis of black seed, can be a boost for their safe use against many severe human diseases. Nigella sativa L. is considered to be an ancient medicinal preparation of Eastern medicine. In this review, we analyzed five books, «The Canon of Medical Science», some other medicinal treatises of Avicenna, as well as modern studies on therapeutic properties and practical applications of black seed. Collected information from various books of the scientist were subjected to pharmacological, phytochemical and biochemical screening.

Keywords: Abuali ibni Sino, Avicenna, black seed, Nigella sativa L, «Canon of Medical Science», «Al-Vohia», phytotherapy, misaj.

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References
  1. Nuriyon AR, Yusufi SD. Farmatsevticheskie poznaniya v Samanidskuyu epokhu [Pharmaceutical knowledge in the Samanid era]. Vestnik Avitsenny [Avicenna Bulletin]. 2017;19(3):422-30. Available from: https://doi. org/10.25005/2074-0581-2017-19-3-422-430.
  2. Nuraliev YuN. Meditsinskaya sistema Ibn Siny [Ibn Sina’s medical system]. Dushanbe, RT: Donish; 2005. 300 p
  3. Abu Ali Ibn Sina (Avicenna). Kanon vrachebnoy nauki. Kniga pervaya [Canon of medical science. Book one]. Dushanbe, RT: Donish; 2010. 476 p.
  4. Abu Ali Ibn Sina (Avicenna). Kanon vrachebnoy nauki. Sochineniya. Kniga vtoraya [Canon of medical science. Writings. The second book]. Dushanbe, RT: Donish; 2012. 323 p
  5. Abu Ali Ibn Sina (Avicenna). Kanon vrachebnoy nauki. Sochineniya. T. 14. Kniga tret’ya, chast’ pervaya [Canon of medical science. Writings. Vol. 14. Book three, part one]. Dushanbe, RT: Donish; 2014. 1000 p.
  6. Abu Ali Ibn Sina (Avicenna). Kanon vrachebnoy nauki. Sochineniya. Kniga IV, chast’ vtoraya [Canon of medical science. Writings. Book IV. Second part]. Tashkent, RUz: Fan; 1980. 553 p.
  7. Abu Ali Ibn Sina. Traktat o lekarstvennykh sredtvakh. Sochineniya. Tom chetvyortyy [Treatise on medicines. Writings. Vol. 4]. Dushanbe, RT: Donish; 2008. 899 p.
  8. Nuraliev YuN. Fitoterapiya impotentsii [Herbal medicine of impotence]. Moscow, RF; 1993. 23 p
  9. Haji AA, Nuraliev Y, Habbasi M, Sharofova M, Bahromova Z. Contribution of Ibn Sina (Avicenna) to the therapy of vitiligo (from the perspective of the medical system of Avicenna and Evidence-Based Medicine. Dushanbe, RT: Contrast; 2015. 268 p.
  10. Fararh KM, Atoji Y, Shimizu Y, Shiina T, Nikami H, Takewaki T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet Sci. 2004;77(2):123-9.
  11. Rchid H, Chevassus H, Nmila R, Guiral C, Petit P, Chokairi M, Sauvaire Y. Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets. Fundam Clin Pharmacol. 2004;18(5):525-9.
  12. Najmi A, Nasiruddin M, Khan RA, Haque SF. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev Ctries. 2008;28(1):11-4.
  13. Kanter M, Akpolat M, Aktas C. Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study. Mol Histol. 2009;40(5-6):379-85.
  14. Kapoor S. Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology. Gastroenterol. 2009;15(17):2170-1.
  15. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012;26(8):1246-8.
  16. Hamdy NM, Taha RA. Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacology. 2009;84(3):127-34.
  17. Meddah B, Ducroc R, El Abbes Faouzi M, Eto B, Mahraoui L, Benhaddou-Andaloussi A, et al. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. Ethnopharmacol. 2009;121(3):419-24.
  18. Fararh KM, Atoji Y, Shimizu Y, Takewaki T. Insulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster. Res Vet Sci. 2002;73(3):279-82.
  19. Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. Effect of Nigella sativa seeds on the glycemic control of patients with type2 diabetes mellitus. Physiol Pharmacol. 2010;54(4):344-54.
  20. Kanter M. Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res. 2008;33(1):87-96.
  21. Altan MF. Effects of Nigella sativa and human parathyroid hormone on bone mass and strength in diabetic rats. Biol Trace Elem Res. 2007;116(3):321-8.
  22. Namazi N, Larijani B, Ayati MH, Abdollahi M. The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis. Ethnopharmacol. 2018;219:173-81.
  23. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. 2008;22(4):447-52.
  24. Ebru U, Burak U, Yusuf S, Reyhan B, Arif K, Faruk TH, et al. Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardio-toxicity in rats. Basic Clin Pharmacol Toxicol. 2008;103(6):574-80.
  25. Demir H, Kanter M, Coskun O, Uz YH, Koc A, Yildiz A. Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic beta-cell damage in cadmium-treated rats. Biol Trace Elem Res. 2006;110(2):151-62.
  26. Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloridetreated rats. Gastroenterol. 2005;11(42):6684-8.
  27. Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 2004;11(1):56-64.
  28. Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology. 2005;49(4):456-64.
  29. Akhondian J, Parsa A, Rakhshande H. The effect of Nigella sativa L. (black cumin seed) on in-tractable pediatric seizures. Med Sci Monit. 2007;13(12):555-9.
  30. Ozugurlu F, Sahin S, Idiz N, Akyol O, Ilhan A, Yigitoglu R, Isik B. The effect of Nigella sativa oil against experimental allergic encephalomyelitis via nitric oxide and other oxidative stress parameters. Cell Mol Biol. 2005;51(3):337-42.
  31. Mousavi SH, Tayarani-Najaran Z, Asghari M, Sadeghnia HR. Protective effect of Nigella sativa extract and thymoquinone onserum/glucose deprivation-induced PC12 cells death. Cell Mol Neurobiol. 2010;30(4):591-8.
  32. Azzubaidi MS, Saxena AK, Talib NA, Ahmed QU, Dogarai BB. Protective effect of treatment with black cumin oil on spatial cognitive functions of rats that suffered global cerebrovascular hypoperfusion. Acta Neurobiol. 2012;72(2):154-65.
  33. Mohamed A, Waris HM, Ramadan H, Quereshi M, Kalra J. Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (creae) using thymoquinone. Biomed Sci Instrum. 2009;45:274-9.
  34. Radad K, Moldzio R, Taha M, Rausch WD. Thymoquinone protects dopaminergic neurons against MPP+ and rotenone. Phytother Res. 2009;23(5):696- 700.
  35. Norouzi F, Hosseini M, Abareshi A, Beheshti F, Khazaei M, Shafei MN, et al. Memory enhancing effect of Nigella sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment in rats. Drug Chem Toxicol. 2018;28:1-10.
  36. Karomatov ID. Prostye lekarstvennye sredstva (opyt primeneniya lekarstvennykh sredstv natural’nogo proiskhozhdeniya v drevney, sovremennoy narodnoy i nauchnoy meditsine) [Simple medicines (experience of using natural medicines in ancient, modern folk and scientific medicine)]. Bukhara, RUz: Durdona; 2012. 888 p.
  37. Abu Ali Ibn Sina. Kniga spasenia. Sochineniya. T. III [The book of salvation. Writings. Vol. III]. Dushanbe, RT: Donish; 2010. 600 p.
  38. Marifova ZA, Azizov IK. Opredelenie fosfatidilkholina i α-tokoferola v masle semyan chernushki posevnoy, proizrastayushchey v Uzbekistane [Determination of phosphatidylcholine and α-tocopherol in oil of the seeds of black chernushka growing in Uzbekistan]. Farmatsiya. 2018;67(1):19-23.
  39. Rud NK, Sampiev AM, Davitavyan NA. Osnovnye rezul’taty fitokhimicheskogo i farmakologicheskogo issledovaniya chernushki posevnoy [The main results of phytochemical and pharmacological studies of blackberries]. Nauchnye vedomosti BelGU. Ser. Meditsina. Farmatsiya. 2013;25:207-21.
  40. Kurbonov BR, Sanginova RI. Vklad Abuali ibni Sino v formirovanie i razvitie estestvennykh nauk [The contribution of Abuali ibni Sino to the formation and development of natural sciences]. Vestnik Avitsenny [Avicenna Bulletin]. 2014;1:124-9.
  41. Karomatov ID, Kobilova DS. Chernushka posevnaya – novaya zhizn’ drevnego lekarstvennogo sredstva (mini obzor) [Nigella sativa – new life of ancient medicine (mini review)]. Biologiya i integrativnaya meditsina. 2018;2:248- 71.
  42. Dzhumaev KSh, Navruzova DA. Antitoksicheskie svoystva chernushki [Black cumin anti-toxic properties]. Biologiya i integrativnaya meditsina. 2019;3:122-35

Authors' information:


Nuraliev Yusuf Nuralievich
Doctor of Medical Sciences, Full Professor, Director General, Institute of Avicenna’s Medicine and Pharmacology
ORCID ID: 0000 0001 8502 2089
Researcher ID: E 734003
E-mail: usuf-nurali@mail.ru

Ganieva Manizha Temurovna
Candidate of Medical Sciences, Head of the Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-5865-8954
Researcher ID: E-4389-2019
E-mail: ganieva.manizha.79@mail.ru

Nuraliev Lukmon Yusufovich
Junior Researcher, Central Scientific Research Laboratory, Avicenna Tajik State Medical University
ORCID ID: 0000 0002 3787 7282
E-mail: nuralievluqmon@gmail.com

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:


Ganieva Manizha Temurovna
Candidate of Medical Sciences, Head of the Department of Neurology and Basics of Medical Genetics, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (918) 668595

E-mail: ganieva.manizha.79@mail.ru