Literature Reviews
doi: 10.25005/2074-0581-2021-23-4-567-578
RISK FACTORS AND CLINICAL MANIFESTATIONS OF LUNG MYCOBACTERIOSIS. SYSTEMATIC REVIEW

T.Kh. Amirova1, I.V. Petrov1, L.V. Ryzhova2, F.S. Petrova1,3, L.V. Petrova1,3, A.A. Almukhametov4,5

1Department of Fundamental Medicine, Mari State University, Yoshkar-Ola, Russian Federation
2Department of Biology, Mari State University, Yoshkar-Ola, Russian Federation
3Bacteriological Laboratory, Republican Tuberculosis Dispensary, Yoshkar-Ola, Russian Federation
4Department of Public Health and Healthcare Organization, Kazan State Medical University, Kazan, Russian Federation
5Scientific and Clinical Center for Precision and Regenerative Medicine, Kazan (Volga Region) Federal University, Kazan, Russian Federation

The present study is a systematic review with a meta-analysis of risk factors for lung mycobacteriosis (LM) and diseases that influence the incidence, clinical manifestations and etiology of the infection under investigation. The authors made a selection of papers. The search for papers was carried out in English and Russian in the PubMed, Web of Science, Сochrane Library, eLibrary electronic databases with the analysis of references from the articles found. Articles published from 2000 to 2020 were selected. The following results are obtained. Regarding smoking: with the two gradations of the factor (the patient smokes or not), the incidence of LM in smokers varied from 13.8±0.03% to 71.2±0.06%. Regarding tuberculosis: the incidence of LM and tuberculosis ranged from 6.7±0.01% to 17.6±0.02%. Regarding chronic obstructive pulmonary disease (COPD): the incidence of LM in patients with COPD was determined on average at 11.2±0.01%. Regarding bronchiectasis: the incidence of bronchiectasis in patients with LM is 30.1±0.02%. Regarding diabetes mellitus: the frequency of patients with LM and diabetes mellitus in one study group was 6.7±0.01%, and in the other – 17.6±0.02%. Regarding malignancies: the frequency of such patients was determined from 17.1±0.04% to 50.0±0.07% of cases. Regarding HIV infection and LM: the incidence of detected LM in patients with HIV was determined on average at the level of 8.9±0.01%. Regarding cough in LM: the frequency of patients with this symptom in the first group was 46.2±0.07%, in the second group – 88.9±0.02%. Regarding hemoptysis in LM: the frequency of patients with this symptom ranged from 3.8±0.03% to 30.1±0.02%. X-ray manifestations of lesions in LM occurred with a frequency of 42.3±0.04% to 100%. The most significant role in etiology belongs to non-tuberculous mycobacteria species, such as slow-growing M. avium complex, and fast-growing M. abscessus complex, M. chelonae, M. fortuitum.

Keywords: Lung mycobacteriosis, nontuberculous mycobacteria, clinical manifestations, risk factors.

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Authors' information:

Amirova Tanzilya Khafizovna
Candidate of Medical Sciences, Associate Professor, Department of Fundamental Medicine, Mari State University
Researcher ID: AAR-9860-2020
ORCID ID: 0000-0002-0666-7418
SPIN: 7099-5423
Author ID: 1057310
Е-mail: tanzilya.amirova.85@mail.ru

Petrov Ilia Vladimirovich
Candidate of Medical Sciences, Associate Professor, Department of Fundamental Medicine, Mari State University
Scopus ID: 57205327803
Researcher ID: AAH-9775-2019
ORCID ID: 0000-0002-2097-5679
SPIN: 1405-9154
Author ID: 825031
Е-mail: ilia.v.petrov@mail.ru

Ryzhova Lyudmila Valeryanovna
Candidate of Biological Sciences, Associate Professor, Department of Biology, Mari State University
Researcher ID: F-3971-2014
ORCID ID: 0000-0003-2512-7078
SPIN: 2715-6207
Author ID: 182760
Е-mail: procopjeva@mail.ru

Petrova Firuza Salavatovna
Assistant, Department of Fundamental Medicine, Mari State University; Bacteriologist, Bacteriological Laboratory, Republican Tuberculosis Dispensary
Scopus ID: 57205334309
Researcher ID: AAS-1585-2020
ORCID ID: 0000-0003-3721-5649
SPIN: 4288-4364
Author ID: 1074740
Е-mail: firka_khusnullina@mail.ru

Petrova Lyudmila Vitalievna
Head of the Bacteriological Laboratory, Republican Tuberculosis Dispensary; Assistant, Department of Biochemistry, Cell Biology and Microbiology, Mari State University
Scopus ID: 57216929237
ORCID ID: 0000-0003-2261-2107
SPIN: 4662-2259
Author ID: 918963
Е-mail: lvps@bk.ru

Almukhametov Arthur Amirovich
Assistant, Department of Public Health and Healthcare Organization, Kazan State Medical University; Deputy Chief Physician for Clinical and Expert Work, Scientific and Clinical Center for Precision and Regenerative Medicine, Kazan (Volga region) Federal University
Scopus ID: 57193998969
Researcher ID: AAE-1070-2020
ORCID ID: 0000-0002-4507-4914
Е-mail: artyr_efendi@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Amirova Tanzilya Khafizovna
Candidate of Medical Sciences, Associate Professor, Department of Fundamental Medicine, Mari State University

424000, Russian Federation, Republic of Mari El, Yoshkar-Ola, PL. Lenin, 1

Tel.: +7 (902) 4337141

E-mail: tanzilya.amirova.85@mail.ru

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