Obstetrics and gynecology

doi: 10.25005/2074-0581-2018-20-2-3-151-156
CORRECTION OF METABOLIC SYNDROME IN WOMEN IN PERIMENOPAUSE

M.S. Rustamova1, M.Kh. Badalova1, S.M. Mukhamadieva2, S.S. Negmatova2, S.A. Radjabova3

1Obstetric Department, Tajik Scientific Research Institute of Obstetrics, Gynecology and Perinatology, Dushanbe, Republic of Tajikistan
2Department of Obstetrics and Gynecology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Dushanbe, Republic of Tajikistan
3City Health Center № 11, Dushanbe, Republic of Tajikistan

Objective: Study of the peculiarities of correction of metabolic disorders in women of the perimenopausal period

Methods: 77 women were surveyed in perimenopause with metabolic syndrome (MS). Conducted analysis of hereditary prevalence and reproductive function; used clinical trails, studied carbohydrate and lipid metabolism, hormonal status; anthropometry, monitoring of arterial pressure, ultrasound of pelvic organs and liver.

Results: Heredity in patients was burdened with cardiovascular diseases (58.4%), obesity (46.8%), diabetes mellitus (38.9%) and oncological pathology (18.2%). All interviewees have not given due attention to eating and enjoyed of food rich in carbohydrates in easily digestible form (81.8%). Patients showed: an increase in the body mass index (BMI) with an average value of 32±2.3 kg/m2, abdominal obesity (100%), insulin resistance (96.1%), dyslipidemia (84.4%), endocrinopathy (58.4%), hyperglycemia (55.8%), arterial hypertension (50.6%), androgen-dependent manifestations (32.5%), "Negroid acanthosis" (31,2%), steatosis of the liver (41.6%). Correction MS included a rational diet, increased motor activity, the appointment Metfogamma and Inoclim. The re-examination showed stabilization of the weight, reliable HOMA index reduction, general cholesterol content, low-density lipoprotein, and an increase of high-density lipoprotein level (p<0.05). Vegetovascular manifestations eliminated in 54.5% of women.

Conclusions: Timely diagnosis and correction of metabolic disorders in women of perimenopausal age normalizes the main metabolism, eliminates the manifestations of menopause syndrome and positively affects the quality of their lives.

Keywords: Metabolic syndrome, insulin resistance, lipid metabolism, carbohydrate metabolism, menopause, rational nutrition.

Download file:


References
  1. Baydurin SA. Metabolicheskiy sindrom: osobennosti patogeneza, printsipy diagnostiki, profilaktiki i lecheniya (obzor literatury) [Metabolic syndrome: the peculiarities of pathogenesis, principles of diagnostics, prevention and treatment (survey of the literature)]. Meditsina. 2013;1:8-13.
  2. Roytberg GE. Metabolicheskiy sindrom [Metabolic syndrome]. Moscow, RF: MEDpress-inform; 2007. 224 p.
  3. Tsanava IA, Sharonova LA, Verbovoy AF. Metabolicheskiy sindrom i serdechno-sosudistye zabolevaniya [Metabolic syndrome and cardiovascular diseases]. RMZh. 2017;11:785-9.
  4. Otunctemur A, Dursun M, Ozbek E, Sahin S, Besiroglu H, Koklu I, et al. Effect of metabolic syndrome on sexual function in pre- and postmeno-pausal women. J Sex Marital Ther. 2015;41(4):440-9. Available from: http://dx.doi.org/10.1080/0092623X.2014.918068.
  5. Gevorkyan MA. Ozhirenie i reproduktivnoe zdorov'e zhenshchiny [Obesity and reproductive health of women]. Ozhirenie i metabolizm. 2008;5(3):13-6.
  6. Dubossarskaya ZM, Dubossarskaya YuA. Metabolicheskiy sindrom i ginekologicheskie zabolevaniya [Metabolic syndrome and gynecological diseases]. Meditsinskie aspekty zdorov'ya zhenshchin. 2010;2:27-38.
  7. Rustamova MS, Mirodzheva SG, Radzhabova SA, Rakhmonova SI. Reproduktivnoe zdorov'e zhenshchin pri metabolicheskom syndrome [Reproductive health of women with metabolic syndrome]. Vestnik Avitsenny [Avicenna Bulletin]. 2012;4:169-76.
  8. Rustamova MS, Muradov AM, Radzhabova SA, Rakhmonova SI, Sirodzheva LD. Komponenty i proyavleniya metabolicheskogo sindroma u zhenshchin s besplodiem [Components and manifestations of metabolic syndrome in women with infertility]. Doklady Akademii nauk Respubliki Tadzhikistan. 2014;57(5):425-31.
  9. Sung KC, Rhee EJ, Ryu S, Kim BJ, Kim BS, Lee WY, et al. Increased cardiovascular mortality in subjects with metabolic syndrome is largely attributable to diabetes and hypertension in 159,971 Korean adults. J Clin Endocrinol Metab. 2015;100(7):2606-12. Available from: http://dx.doi.org/10.1210/jc.2014-4031.
  10. Pasquali R. Metabolic syndrome in polycystic ovary syndrome. Front Horm Res. 2018;49:114-30. Available from: http://dx.doi.org/10.1159/000485995.
  11. Laktionov KP, Nikolaenko LO, Berishvili AI. Metabolicheskiy sindrom i rak organov reproduktivnoy sistemy (obzor literatury) [Metabolic syndrome and reproductive organ cancers: a review of literature]. Opukholi zhenskoy reproduktivnoy sistemy. 2014;2:56-8.
  12. Chernyshova AL, Kolomiets LA, Bochkaryova NV, Asadchikova NO. Metabolicheskiy sindrom, vzaimosvyaz' s protsessami kantserogeneza endometriya [Metabolic syndrome, interraction with endometrial carcinogen-esis]. Sibirskiy onkologicheskiy zhurnal. 2008;5:68-74.
  13. Shishkin AN, Khudyakova NV, Smirnov VV, Nikitina EA. Metabolicheskiy sindrom u zhenshchin v perimenopauze [Metabolic syndrome in perimenopausal women]. Vestnik SPbGU. Medicina. 2013;11(3):39-56.
  14. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome. Circulation. 2009;120(16):1640-5. Available from: http://dx.doi.org/10.1161/CIRCULATIONAHA.109.192644.
  15. Yilmaz B, Vellanki P, Ata B, Yildiz BO. Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis. Fertil Steril. 2018;109(2):356-64.e32. Available from: http://dx.doi.org/10.1016/j.fertnstert.2017.10.018.
  16. Doskina EV. Sovremennye vozmozhnosti kompleksnoy terapii u zhenshchin menopauzal'nogo vozrasta s metabolicheskim sindromom [Complex therapy of menopausal women with metabolic syndrome]. Doktor.Ru. 2009;6:1-3.
  17. Rustamova MS, Badalova MKh, Radzhabova SA, Shumilina OV, Abdurakhmanova MA. Markyory i komponenty metabolicheskogo sindroma u zhenshchin reproduktivnogo i perimenopauzal'nogo vozrastov [Markers and components of the metabolic syndrome in women of reproductive and perimenopausal age]. Akademicheskiy zhurnal Zapadnoy Sibiri. 2015;11(5):71-2.
  18. Bokaryov IN. Metabolicheskiy sindrom [Metabolic syndrome]. Klinicheskaya meditsina. 2014;8:71-6

Authors informations:

Rustamova Mehriniso Sanginovna, Doctor of Medical Sciences, Leading Scientific Officer of the Obstetrics Department, Tajik Scientific Research Institute of Obstetrics, Gynecology and Perinatology

Badalova Mavzuna Kholbekovna, Postgraduate Student of Obstetrics Department, Tajik Scientific Research Institute of Obstetrics, Gynecology and Perinatology

Mukhamadieva Saodat Mansurovna, Doctor of Medical Sciences, Full Professor, Professor of the Department of Obstetrics and Gynecology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan

Negmatova Surayo Sabirdzhanovna, Postgraduate Student of the Department of Obstetrics and Gynecology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan

Radjabova Surayo Amonovna, Head of the Women's Consultation, City Health Center № 11

Address for correspondence:

Rustamova Mehriniso Sanginovna

Doctor of Medical Sciences, Leading Scientific Officer of the Obstetrics Department, Tajik Scientific Research Institute of Obstetrics, Gynecology and Perinatology

734002, Republic of Tajikistan, Dushanbe, str. Tursunzade, 31

Tel.: (+992) 935 756464

E-mail: mehrinisor@mail.ru

Materials on the topic: