retracted
Pathophysiology
doi: 10.25005/2074-0581-2018-20-2-3-254-260
FEATURES OF THE CYTOKINE BALANCE IN EXTRAPULMONARY TUBERCULOSIS BEFORE AND DURING THE TREATMENT

K.M. Mukanbaev1, M.D. Abdiev2, D.K. Kozhomkulov2, T.Kh. Kudayberdiev1, M.D. Kozhomkulov2, E.V. Dudenko3

1Department of Extrapulmonary Surgery, National Center for Phthisiology, Bishkek, Kyrgyz Republic
2Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology, Bishkek, Kyrgyz Republic
3Laboratory of Immunology and Molecular Biology, National Center for Phthisiology, Bishkek, Kyrgyz Republic

Objective: To study the products and balance of cytokines (CK) to improve the diagnosis and monitoring of the effectiveness of treatment of extrapulmonary tuberculosis (TB).

Methods: During the period 2012-2015, the spontaneous production of cytokines IL-6, IL-8, IL-4 and IL-10 in the blood serum has been investigated of 137 patients with different forms of TB in the dynamics of the chemotherapy process (before the onset of intensive chemotherapy and after 2 months of treatment). The level of CK is determined for comparison, in 31 patients with tuberculosis of the urogenital system (TB UGS) and in 28 patients with tuberculosis of bones and joints (TB BJ) was determined.

Results: Study of CK balance in patients with pulmonary TB with multiple drug resistance and drug sensitivity, as well as in extrapulmonary forms of tuberculosis (TB BJ and TB UGS) in the background of anti-tuberculous chemotherapy, can serve as an immunological method of monitoring the effectiveness of treatment.

Conclusion: CK and cytokine balance can be used as response markers of the immune system to anti-tuberculosis treatment and additional evaluation criteria for assessing the severity of the inflammatory process.

Keywords: Cytokines, cytokine balance, extrapulmonary tuberculosis, tuberculosis of bones and joints, urogenital tuberculosis.

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References
  1. Delogy G, Zumbo A, FaddaDelogu G. Microbial and immunological di-agnosis of tuberculosis spondylodiscitis. European Review for Medical and Pharmacological Sciences. 2012;2:73-8.
  2. Markelova EV, Kastyushko AV, Krasnikov VE. Patogeneticheskaya rol’ narusheniy v sisteme tsitokinov pri infeksionno-vospalitel’nykh zabolevaniyakh [Pathogenetic role of disturbance in the system of cytokines in infectious and inflammatory diseases]. Tikhookeanskiy meditsinskiy zhurnal. 2008;3:24-9.
  3. Balkwill F. Cytokine cell biology. Oxford, GB: Oxford University Press; 2001. 272 p.
  4. Kitaev MI, Soburov KA. Regional’nye normy pokazateley immuniteta i immunogeneticheskie markyory u gornogo naseleniya Kyrgyzstana [Regional norms of immunogenetic markers in the mountainous populations of Kyrgyzstan]. Bishkek, KR: Ilim; 2009: 157 p.
  5. Tsoy LG. Tsitokiny i khronicheskaya serdechnaya nedostatochnost’ [Cytokines and chronic heart failure]. Vestnik KRSU. 2017;17(7):72-5.
  6. Serebrennikova SN, Selinskiy IZh. Rol’ tsitokinov v vospalitel’nom protsesse (soobshchenie 1) [The role of cytokines in the inflammatory process (part 1)]. Sibirskiy meditsinskiy zhurnal. 2008;6:5-7.
  7. Makarova VI, Makarov AI. Rol’ tsitokinov v realizatsii vospalitel’noy reaktsii [The role of cytokines in realization of inflammatory reaction]. Ekologiya cheloveka. 2008;5:31-5.
  8. Zaytseva GA, Vershinina OA, Matrokhina OI, Senkina EA, Karpova MV. Tsitokinovyy status donorov krovi i eyo komponentov [Cytokine status of blood donors and its components]. Fundamental’nye issledovaniya. 2011;3:61-5.
  9. Sekachyova MI, Bueverov AO. Terapevticheskie vozmozhnosti vliyaniya na balans tsitokinov pri zabolevaniyakh kishechnika i pecheni [Therapeutic possibilities of influence on the balance of cytokines in diseases of the intestine and liver]. Russkiy meditsinskiy zhurnal. 2010;5:40.
  10. Khasanova RR, Voronkova OV, Urazova OI. Rol’ tsitokinov v modulyatsii subpopulyatsionnogo sostava limfotsitov krovi u bol’nykh tuberkulyozom lyogkikh [The role of cytokines in modulating the subpopulation of lymphocytes in the blood in patients with pulmonary tubercu-losis]. Problemy tuberkulyoza i bolezney lyogkikh. 2008; 3:31-5.
  11. Sharma D, Dhiman P, Rajendiran S. Osteoarticular tuberculosis: in search of new biomarkers. European Orthopaedics and Traumatology: Published online; 2015. Available from:www.link.springer.com/article/10.1007/ s12570-015-0290x.
  12. Clifford V, Zufferey C, Germano S, Ryan N, Leslie D, Street A, et al. Do anti-tuberculosis antibiotics or steroid therapy influence cytokine production in quantiferon-TB gold in tubebased immunoassays? Pathology. 2014;46(1):99-100.
  13. Tan Q. Characterization of Th1- and Th2-type immune response in human multidrug-resistent tuberculosis. European Journal of Clinical Mi-crobiology & Infectious Diseases. 2012;6:1233-42.
  14. Oliveira LRC, Peresi E, Golim MA, Gatto M, Araújo Junior JP, Costa ÉAPN, et al. Analysis of toll-like receptors, iNOS and cytokine profiles in patients with pulmonary tuberculosis during anti-tuberculosis treatment. PLoS One. 2014; 0088572. Available from: http://dx.doi.org/10.1371/journal.pone.0088572
  15. Kumar NP, Gopinath V, Sridhar R, Hanna LE, Banurekha VV, Jawahar MS, et al. IL-10 dependent suppression of type 1, type 2 and type 17 cytokines in active pulmonary tuberculosis. PLoS One. 2013; 0059572. Available from: http://dx.doi.org/10.1371/journal.pone.0059572.

Authors' information:

Mukanbaev Kasymbek Mukanbaevich,
Candidate of Medical Sciences, Leading Researcher, Department of Extrapulmonary Surgery, National Center for Phthisiology

Abdiev Marat Dzhumadylovich,
Candidate of Medical Sciences, Deputy Director for Science of the National Center for Phthisiology

Kozhomkulov Dzhumabay Kozhomkulovich,
Candidate of Medical Sciences, Leading Researcher, Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology

Kudayberdiev Turatbek Khalmatovich,
Researcher, Department of Extrapulmonary Surgery, National Center for Phthisiology

Kozhomkulov Meder Dzhumabaevich,
Researcher, Department of Bones and Joints Tuberculosis Surgery, National Center for Phthisiology

Dudenko Elena Vyacheslavovna,
Researcher of the Laboratory of Immunology and Molecular Biology, National Center for Phthisiology

Conflicts of interest: No conflict

Address for correspondence:

Abdiev Marat Dzhumadylovich

Candidate of Medical Sciences, Deputy Director for Science of the National Center for Phthisiology

720020, Kyrgyz Republic, Bishkek, Akhunbaev str., 90a

Tel.: (+996) 312 570925

E-mail: marat.abdievtbc@gmail.com

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