Pathophysiology
doi: 10.25005/2074-0581-2018-20-2-3-240-244
THE PROBLEMS OF EARLY DETECTION OF TUBERCULOSIS COMBINED WITH HIV INFECTION IN MODERN ECONOMIC CONDITIONS OF THE REPUBLIC OF TAJIKISTAN

R.U. Makhmudova1, P.U. Makhmudova2, K.A. Zakirova1

1Department of Phthisiopulmonology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Dushanbe, Republic of Tajikistan
2Republican Center for the Protection of the Population from Tuberculosis, Dushanbe, Republic of Tajikistan

Objective: To study methods of early detection of TB diagnosis, morbidity, and prevalence of combined infection of TB/HIV and mortality from TB among HIV-infected patients.

Methods: The analysis of the detection, prevalence and mortality from tuberculosis among HIV-infected patients carried out according to official report data of the Republican Center for Protection of the Population from Tuberculosis for 2005-2017 years.

Results: Reach people living with HIV (PLHIV) to detect (TB) in them remains at a low level despite the increase in this indicator from 18% in 2006 to 56% in 2017. The TB incidence rate in Tajikistan in 2007-2008 was 85.1-85.2 cases per 100 thousand of the population and in 2015-2016 it decreased to 60.6-58.6 cases per 100 thousand of the population. Prevalence rates of HIV infection in 2007-2008 amounted to 15.5-20.1 cases per 100 thousand of the population, and in 2015-2016 it increased to 106.0-115.1 per 100 thousand of the population, i.е. marked its growth by 15.1 times. The prevalence of combined infection of TB/HIV in Tajikistan in 2006 was only 12 cases, and in 2016, it reached 1227, an increase of 102 times. The lethality among PLHIV from TB in 2006 was 41.4%; in the future, it increased annually and in 2011 reached 71.2% of the total number of PLHIV. Subsequent years, this indicator gradually decreased to 45% in 2016 (reaching 26.2%).

Conclusion: The obtained results testify that the detection and diagnostics of TB among HIV-infected persons in Tajikistan carried out in the modern level. The prevalence of TB/HIV remains tense. The mortality rate among PLHIV from TB for 2006-2016 decreased from 71.2% to 45%, i.e. by 26.2%.

Keywords: Tuberculosis, prevalence, TB/HIV combined infection, mortality.

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Authors' information:

Makhmudova Rukhsora Ulmasovna,
Assistant of the Department of Phthisiopulmonology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan

Makhmudova Parvina Ulmasovna,
Phthisiatrician, Republican Center for the Protection of the Population from Tuberculosis

Zakirova Kurbonkhon Akramovna,
Doctor of Medical Sciences, Head of the Department of Phthisiopulmonology, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan

Conflicts of interest: No conflict

Address for correspondence:

Mahmudova Parvina Ulmasovna

Phthisiatrician, Republican Center for Protection of the Population from Tuberculosis

734025, Republic of Tajikistan, Dushanbe, Bukhoro str., 53

Tel.: (+992) 918 280003

E-mail: parvinahon.82@mail.ru

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