Pathophysiology
doi: 10.25005/2074-0581-2018-20-2-3-261-265
THE ROLE OF BIOCHEMICAL BLOOD ANALYSIS IN ACTIVITY VERIFICATION OF PULMONARY TUBERCULOSIS
1Department of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Phthisiopulmonology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Objective: To study the interconnection of inflammatory process of vessels endothelium with biochemical changes in verification of the pulmonary tuberculosis (PTB) diagnosis.
Methods: Results of a study of 56 PTB patients are given in the age of 18-50 years, 26 of them with a drug-resistant (DR) form of PTB and 30 with a drug-sensitive (DS) form of PTB. The status of the vessels endothelium was judged by the amount of C-reactive protein (CRP), fibrinogen, and Willebrand factor.
Results: The studies have shown a significant increase in the content of CRP (4.22±0.13), fibrinogen (4.21±0.21) and Willebrand factor (114.0±2.5) in patients with DR PTB. The received data indicate that the course of a specific process of patients of PTB with extensive DR is more severe than in patients with DS PTB. The DR PTB is accompanied by the development of the syndrome of a systemic inflammatory response, whose manifestation is interrelated with the severity of the patient's condition. The syndrome of a systemic inflammatory response is manifested by an increase in the blood serum of the C-reactive protein, fibrinogen, and Willebrand factor. The values of CRP within 4-5 mg/l are an early indicator of the process activity.
Conclusion: As a diagnostic test for PTB can be used to determine the status of endothelium blood vessels criteria for which are elevated levels of CRP, fibrinogen, and Willebrand factor.
Keywords: Tuberculosis, biochemical study, endothelium condition, C-reactive protein, fibrinogen, Willebrand factor.
References
- Vasilyeva IA, Belilovskiy ЕМ, Borisov SE. Global’nye otchyoty Vsemirnoy organizatsii zdravookhraneniya po tuberkulyozu: formirovanie i interpretatsiy [Global report of the World Health Organization on tuberculosis: the formation and interpretation]. Тuberkulyoz i bolezni lyogkikh. 2017;95(5):5-13.
- Bobokhodjaev OI, Sirodjidinova UYu, Djumaev RR, Radjabov DM. Prichiny razvitiya tuberkulyoza lyogkikh v Respublike Tadzhikistan [Causes of development of pulmonary tuberculosis in the Republic of Tajikistan]. Zdravookhranenie Tadzhikistana. 2015;3:41-7.
- Sirodjidinova UYu, Bobokhojaev OI, Dustmatova ZSh, Mirzoeva FO. Аnaliz situatsii po tuberkulyozu v Respublike Tadzhikistan [Analysis of the situation of tuberculosis in the Republic of Tajikistan]. Tuberkulyoz i bolezni lyogkikh. 2015;2:39-44.
- Каminskaya GO, Аbdulaev RYu, Коmissarova OG. Оsobennosti metabolicheskoy aktivnosti sosudistogo endoteliya u bol’nykh tuberkulyozom lyogkikh [Features of metabolic activity of vascular endothelium in patients with pulmonary tuberculosis]. Vestnik RAMN. 2012;11:29-32.
- ErokhinVV. О nekotorykh mekhanizmakh patogeneza tuberkulyoza [On some mechanisms of the pathogenesis of tuberculosis]. Tuberkulyoz i bolezni lyogkikh. 2009;11:3-8.
- Коmissarova OG. Оsobennosti techeniya protsessa i effektivnost’ lecheniya u bol’nykh lekarstvenno ustoychivym tuberkulyozom lyogkikh pri razlichnoy intensivnosti sindroma sistemnogo vospaleniya [Peculiarities of the course of the process and the effectiveness of treatment in patients with drug resistant pulmonary tuberculosis at different intensity of the syndrome of sys-temic inflammation]. Tuberkulyoz i bolezni lyogkikh. 2016;9:32-8.
- Bobokhodjaev OI, Nuraliev ММ. Gepatotoksicheskie reaktsii pri khimioterapii bol'nykh tuberkulyozom [Hepatotoxic reactions in chemotherapy of tuberculosis patients]. Izvestiya Akademii nauk Respubliki Tadzhikistan. 2015;4:63-9.
- Khudushina ТА, Voloshina EP. Lekarstvennaya ustoychivost’ mikobakterii tuberkulyoza u vpervye vyyavlennikh bol’nykh tuberkulyozom lyogkikh [Drug resistance of mycobacterium tuberculosis in newly diagnosed patients with pulmonary tuberculosis]. Problemy tuberkulyoza i bolezney lyogkikh. 2007;12:37-9.
- Аbdullaev RYu, Каminskaya GO, Коmissarova OG. Syvorotochnyy uroven’ oksida azota v otsenke sistemnogo vospaleniya u bol’nykh s lekarstvenno ustoychivym tuberkulyozom lyogkikh [Serum level of nitric oxide in the evaluation of systemic inflammation in patients with drug-resistant tuberculosis in the lungs]. Problemy tuberkulyoza i bolezney lyogkikh. 2009;5:40-3.
- Paulus P, Jennewien S. Biomarkers of endothelial dysfunction: can help us deciphering systemic inflammation and sepsis. Biomarkers. 2011;16(1):11-21.
- Gelberg IS, Volf SB, Аleks ЕN. Narushenie rezistentnosti metaboliz-ma pri tuberkulyoze i metody patogeneticheskogo vozdeystviya v ego kompleksnom lechenii [Disturbance of the resistance of metabolism in tuberculosis and methods of pathogenetic influence in its complex treatment]. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2009;1:123-8.
- Titov VN. Biokhimicheskie markyory endoteliya i ego rol’ v edinenii funktsional’no raznykh pulov mezhkletochnoy sredy i pula vnutrisosudistoy zhidkosti [Biochemical markers of the endothelium and its role in functionally different pools of the intercellular environment and the pool of intravascular fluid]. Klinicheskaya laboratornaya diagnostika. 2007;4:6-7.
- Nuraliev ММ, Avezova NH. Lekarstvenno-indutsirovannye porazheniya pecheni i ikh diagnosticheskie markyory [Drug-induced liver damage and their diagnostic markers]. Vestnik Tadzhikskogo natsional’nogo universiteta. 2015;1:246-55.
- Kaminskaya GO. Uchastie sistemy gomeostaza v formirovanii sindroma sistemnogo vospalitel’nogo otveta u bol’nykh tuberkulyozom lyogkikh [Participation of the homeostasis system in the formation of the systemic in-flammatory response syndrome in patients with pulmonary tuberculosis]. Tuberkulyoz i bolezni lyogkikh. 2011;2:52-8.
- Wilson D, Bardi M. Performance of serum C-reactive protein as a screening test for smear-negative tuberculosis in an ambulatory high HLV prevalence population. PLoS One. 2011;6(1):15248.
- Abdullaev RYu, Komissarova OG. Syvorotochnyy amiloidnyy belok А – ego rol’ i uchastie v patologii organov dykhaniya [Serum amyloid protein A-its role and participation in the pathology of respiratory organs]. Tuberkulyoz i bolezni lyogkikh. 2011;2:3-8.
Authors' information:
Nasyrdzhanova Khursand Rakhimovna,
Assistant of the Department of Biochemistry, Avicenna Tajik State Medical University
Saburova Anna Mukhamedovna,
Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University
Sirodjidinova Umrniso Yusupovna,
Doctor of Medical Sciences, Full Professor, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University
Makhsudova Musallama Salikhovna,
Assistant of the Department of Biochemistry, Avicenna Tajik State Medical University
Conflicts of interest: No conflict
Address for correspondence:
Saburova Anna Mukhamedovna
Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University
734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139
Tel.: (+992) 917 241175
E-mail: 20@tajmedun.tj
This work is licensed under a Creative Commons Attribution 4.0 International License.
Materials on the topic:
- NANOPARTICULATE BDNF AS A POTENTIAL ANTIDEPRESSANT VIA NEUROENDOCRINE MECHANISMS IN EXPERIMENTAL MODEL OF DEPRESSION
- EVALUATION OF PROTEOLYTIC ACTIVITY IN EXPERIMENTAL PERITONITIS WITH SEROGUARD® TREATMENT
- MORPHOLOGICAL FEATURES OF PLACENTAS IN PREGNANCIES WITH FETAL GROWTH RESTRICTION SYNDROME
- EXPERIMENTAL DEPRESSION-MODULATED ACTIVATION PATTERN OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
- EVALUATION OF HEMATOTOXICITY OF NEW DERIVATIVES OF CONDENSED 3-AMINOTHIENO[2,3-b]PYRIDINES AND 1,4-DIHYDROPYRIDINES WITH HIGH ANALGESIC ACTIVITY
- LABORATORY BIOMARKERS FOR BRAIN DAMAGE IN DIABETES MELLITUS
- EFFECT OF ACTH6-9-PRO-GLY-PRO PEPTIDE ON SPECTRAL PARAMETERS OF HEART RATE VARIABILITY IN WISTAR RATS DURING PHYSICAL EXERTION (PILOT STUDY)
- IN VIVO STUDY OF WOUND-HEALING ACTIVITY OF POLYSACCHARIDE GEL WITH ENCAPSULATED SEA-BUCKTHORN OIL (HIPPOPHAE RHAMNOIDES)
- DYNAMICS OF DRUG RESISTANCE IN M. TUBERCULOSIS DURING THE NEW CORONAVIRUS INFECTION PANDEMIC IN DUSHANBE: THE NEED FOR URGENT MEASURES
- IMPLEMENTATION STUDY IN PREVENTION AND CONTROL OF DRUG-RESISTANT TUBERCULOSIS DURING THE COVID-19 PANDEMIC IN DUSHANBE