Pathophysiology
doi: 10.25005/2074-0581-2018-20-2-3-320-324
TO THE ISSUE OF THE REACTIVATION OF THE TUBERCULOSIS PROCESS

O.I. Bobokhojaev1, U.Yu. Sirodjidinova1, R.R. Djumaev1, I.S. Makhmudzoda2

1Department of Phthisiopulmonology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Scientific Research Institute of Prophylaxis Medicine of Tajikistan, Dushanbe, Republic of Tajikistan

Objective: The article dedicated to debating the degree of certainty of verification of certain types of reactivation of the tuberculosis process, such as relapse, reinfection and superinfection. Analysis of native and foreign publications for the last 10 years on this issue conducted. The authors confirm that even if the outcome of a successful treatment of tuberculosis is deduced based on bacterioscopic and cultural conversion of sputum (outcome "cured"), it is not possible to claim reinfection after eradication or elimination of M. tuberculosis, because it does not exclude its presence in the parenchyma of the lungs, lymph nodes or other organs. If the outcome of successful treatment for various reasons displayed without laboratory confirmation (outcome "completed treatment"), the more so it is impossible to confirm the relapse or reinfection of the disease. Summing up the analysis of the literature, the authors point out the necessity of a differentiated approach in observations in practice and in scientific researches. The use of several costly methods of verification of the form reactivating of the tuberculosis process is not always justified. Ultimately, as recommended WHO, these cases register as new and, depending on the sensitivity to anti-tuberculosis drugs picks up the regimen of repeated chemotherapy.

Keywords: Tuberculosis, reactivation, exacerbation, relapse, reinfection, superinfection..

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Authors' information:

Bobokhojaev Oktam Ikramovich, Doctor of Medical Sciences, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University

Sirodjidinova Umrniso Yusupovna, Doctor of Medical Sciences, Full Professor, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University

Djumaev Rahmatullo Rahmonovich, Competitor of Department of Phthisiopulmonology, Avicenna Tajik State Medical University

Makhmudzoda Isfandiyor Safari, Competitor of Scientific Research Institute of Prophylaxis Medicine of Tajikistan

Conflicts of interest: No conflict

Address for correspondence:

Bobokhojaev Oktam Ikramovich

Doctor of Medical Sciences, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: (+992) 985 868080

E-mail: bobokhojaev@mail.ru

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