Infectious Diseases
doi: 10.25005/2074-0581-2018-20-4-357-361
DYNAMICS OF THE PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES DURING A WHOOPING COUGH IN CHILDREN OF THE FIRST YEAR OF LIFE

N.M. Khodzhaeva, M.D. Madzhonova

Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the state of cytokine status in the dynamics of the disease and find out its role in the course of a whooping cough in children of the first year of life.

Methods: Twenty children have surveyed at the age of 1-year-old with a diagnosis of a whooping cough, which formed the main group, as well as 30 practically healthy children of the same age who formed the control group. The concentration of pro-inflammatory cytokines (IL-6, IFN-γ) and the anti-inflammatory cytokine (IL-4) studied by enzyme immunoassay.

Results: The analysis of the peculiarities of the cytokine profile in patients with whooping cough showed that the most significant violations concerned the ability of lymphocytes to produce IFN-γ, which was low, starting from the 2nd week, and throughout the disease in all variants of whooping cough. Also paid attention to the active products the of one of the pro-inflammatory cytokines IL-6, which exceeded control value in half and more. The level of antiinflammatory cytokine IL-4 was not significantly different from such of practically healthy children.

Conclusion: Multidirectional changes in the level of cytokines in the dynamics of the infectious process and depending on the severity of the pathological process, allowing predicting the current outcome of this infection. Analysis of the obtained data revealed a correlation of different levels between pro-inflammatory and anti-inflammatory cytokines, which play an important role in inflammatory mediators during whooping cough in children.

Keywords: Whooping cough, cytokine profile, children, pro-inflammatory, anti-inflammatory cytokines, interleukins.

Download file:

References
  1. Kirsanova TA. Kliniko-immunologicheskie osobennosti koklyusha u detey rannego vozrasta na sovremennom etape [Clinical and immunological features of whooping cough in young children at the present stage]. Zhivye i biokosnye sistemy [Elektronnyiy resurs] 2013 5: Rezhim dostupa: http:// www.jbks.ru/archive/issue-5/article-5.
  2. Niyazalieva MS, Toygombaeva VS, Asykbekova BSh, Orozakunova NO. Sovremennaya epidemiologicheskaya situatsiya vaktsinoupravlyaemykh infektsiy sredi zhiteley g. Bishkek [Current epidemiological situation of vaccine-preventable infections among residents of Bishkek]. Vestnik Avitsenny [Avicenna Bulletin]. 2016;1:85-90.
  3. Uchaykin VF, Shamsheva OV. Infektsionnye bolezni u detey [Infectious diseases in children]. Moscow, RF: GEOTAR-Media; 2015. 800 p.
  4. Timchenko VN, Kaplina TA, Yarv NV. Koklyushnaya infektsiya u detey v sovremennykh usloviyakh [Pertussis infection in children in modern conditions]. Detskie infektsii. 2009;3:28-30.
  5. Khodzhaeva NM, Fayzulloev NF, Tokmalaev AK. Tsitokinovyy profil’ pri malyarii u detey [Cytokine profile in malaria in children]. Meditsinskaya parazitologiya i parazitarnye bolezni. 2008;4:22-6.
  6. Zheleznikova GF. Tsitokiny v diagnostike i prognoze techeniya infektsiy [Cytokine profile in malaria in children]. Neyroimmunologiya. 2008;6(3): 1-4.
  7. Alekseeva LA, Mazaeva EM, Skripchenko NV, Monakhova NE, Bessonova TV. Tsitokiny v tserebrospinal’noy zhidkosti pri meningitakh u detey [Cytokines in cerebrospinal fluid in children with meningitis]. Infektologiya. 2014;6(1):54-9
  8. Epifantseva NV, Vitkovskiy YuA. Limfotsitarno-trombotsitarnaya adgeziya i interleykinovyy profil’ pri koklyushe u detey Zabaykal’ya [Lymphocyteplatelet adhesion and interleukin profile in whooping cough in Transbaikalia children]. Vestnik sovremennoy klinicheskoy meditsiny. 2010; 3.Pril.1:64.
  9. Epifantseva NV. Uroven’ tsitokinov pri koklyushe u detey Zabaykal’ya [Cytokine level in whooping cough in Transbaikalia children]. Zabaykal‘skiy meditsinskiy vestnik. 2011;1:62-5.
  10. Popova OP, Fyodorova IM, Koteleva SI. Osobennosti tsitokinovogo profilya u detey, bol’nykh koklyushem [Features of cytokine profile in children with whooping cough]. Epidemiologiya i infektsionnye bolezni. 2013; 5:33-7.
  11. Popova OP, Gorelov AV. Sovremennye aspekty koklyusha u detey [Modern aspects of pertussis in children]. Moscow, RF: GEOTAR-Media; 2017. 192 p.
  12. Khodzhaeva NM, Tokmalaev AK. Rol’ tsitokinov v klinicheskom techenii tropicheskoy malyarii u detey [The role of cytokines in the clinical course of tropical malaria in children]. Meditsinskaya parazitologiya i parazitarnye bolezni. 2011;2:28-30.
  13. Babachenko IV, Yarv NE, Kalinina NM, Davydova NI. Osobennosti immunnoy reaktivnosti detey pervogo goda zhizni, bol’nykh koklyushem [Features of immune reactivity in children of the first year of life, who have pertussis]. Pediatriya. 2008;87(3):62-7.
  14. Smirnov IE, Mityushin IL, Kucherenko AG, Bokrodze MD. Tsitokinovyy profil’ pri bakterial’noy i virusnoy infektsii u detey [Cytokine profile for bacterial and viral infections in children]. Rossiyskiy pediatricheskiy zhurnal. 2014;4:14-9.
  15. Nikitina VV, Zakharova NB, Gladilin GP, Korshunov GV. Vliyanie kontsentratsiy oksida azota i aktivnosti okistata na razvitie vospalitel’nykh izmeneniy sosudistoy stenki [The effect of nitric oxide concentrations and oxide activity on the development of inflammatory changes in the vascular wall]. Klinicheskaya laboratornaya diagnostika. 2014;5:12-3.
  16. Popova OP, Skirda TS, Fyodorova IM, Koteleva SI. Osobennosti spetsificheskogo gumoral’nogo otveta i tsitokinovoy regulyatsii pri koklyushe u detey [Features of specific humoral response and cytokine regulation in whooping cough in children]. Epidemiologiya i infektsionnye bolezni. 2015; 20(5):42-8.

Authors' information:

Khodzhaeva Nigina Murodovna
Doctor of Medical Sciences, Associate Professor, Professor of the Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University

Madzhonova Manizha Dzhumaevna
PhD Student of the Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University

Conflicts of interest: No conflict

Address for correspondence:

Khodzhaeva Nigina Murodovna

Doctor of Medical Sciences, Associate Professor, Professor of the Department of Pediatric Infectious Diseases, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave, 139

Tel.: +992 (919) 834422

E-mail: nigina51@rambler.ru

Materials on the topic:
  1. INFECTIOUS TOXIC SHOCK IN TYPHOID FEVER DURING THE EPIDEMIC PERIOD AND AFTER IT
  2. EFFICACY OF ANTIRETROVIRAL THERAPY IN PATIENTS IN THE LATE STAGE HIV INFECTION
  3. CONDITION OF LIPID PEROXIDATION AND ANTIOXIDANT SYSTEM IN CHILDREN WITH SCARLET FEVER

◄ Back to the list