Infectious Diseases
doi: 10.25005/2074-0581-2020-22-4-542-547
INFECTIOUS TOXIC SHOCK IN TYPHOID FEVER DURING THE EPIDEMIC PERIOD AND AFTER IT

Z.F. Tagozhonov1, N.S. Odinaev2, I.N. Nazimov1, I. Davronzoda2

1451 Military Hospital of the Russian Ministry of Defense, Dushanbe, Republic of Tajikistan
2Department of Epidemiology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the frequency and causes of the development of infectious toxic shock (ITS) in typhoid fever in military servants during the epidemic and the post-epidemic period.

Methods: In 451 Military Hospital of the Russian Ministry of Defense (Dushanbe, Republic of Tajikistan) from 1995 up to 2009 were treated 837 military servants, hospitalized with a diagnosis of typhoid fever, of which 38 (4.54%) had ITS. The degree of endogenous intoxication and the parameters of the cardiovascular, respiratory and urinary systems evaluated.

Results: It’s been identified during the epidemic, since (1996 to 1999) from 350 (41.8%) hospitalized patients in 20 (5.7%) and the post-epidemic period (2000-2009) out of 487 (58.2%) patients in 18 (3.6%) were diagnosed the ITS. The intensive therapy provided ITS relief and achieving a favorable outcome for all 38 patients.

Conclusion: Thus, ITS which is one of the formidable complications of typhoid fever, was more frequently occurred in the epidemic period (5.7%), which coincided with the period of armed confrontation. In the post-epidemic period, which was on peacetime, its frequency was 3.6% of all hospitalized patients with typhoid fever.

Keywords: Typhoid fever, complications, infectious toxic shock, epidemic period, post-epidemic period.

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Authors' information:

Tagozhonov Zarif Fozilovich
Candidate of Medical Sciences, Anesthesiologistresuscitator, Department of Anesthesiology and Resuscitation, 451 Military Hospital of the Ministry of Defense of Russia
ORCID ID: 0000-0002-1555-4407
E-mail: zariftagozhonov@gmail.com

Odinaev Niyoz Safarovich
Doctor of Medical Sciences, Head of the Department of Epidemiology, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-5406-6422
E-mail: vaska5@list.ru

Nazimov Igor Nikolaevich
Head of the Infectious Diseases Department, 451 Military Hospital of the Ministry of Defense of Russia
ORCID ID: 0000-0001-5614-4191
E-mail: orsvg@mail.ru

Davronzoda Ikrom
Post-graduate Student, Department of Epidemiology, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-9159-9183
SPIN: 9969-5983
E-mail: davronzoda89@mail.ru

Conflicts of interest: No conflict

Address for correspondence:

Odinaev Niyoz Safarovich
Doctor of Medical Sciences, Head of the Department of Epidemiology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (918) 623129

E-mail: vaska5@list.ru

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