Rheumatology
doi: 10.25005/2074-0581-2019-21-4-610-617
COMPARATIVE CLINICAL LABORATORY AND INSTRUMENTAL ASSESSMENT OF EFFECTIVENESS OF MONO- AND COMBINED THERAPY OF TERAFLEX WITH OSTENILE IN PATIENTS WITH PRIMARY KNEE OSTEOARTHRITIS

O.R. Rizoeva, Yo.U. Saidov, Kh.R. Makhmudov

Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: Comparative evaluation of the effectiveness of mono- and combined therapy of Teraflex with Ostenile in patients with early and developed primary knee osteoarthritis (OA).

Methods: A comparative analysis and evaluation of the effectiveness of mono- and combined therapy of Teraflex with Ostenile in patients with primary knee OA (n=98) is presented. Depending on the evolutional stages of the disease progression, patients were divided into three groups: the first group – patients with stage I of OA (n=24); group II – patients with stage II of OA (n=39); group III – patients with stage III of OA (n=35). The duration of the study was 9 months (6 months of the therapy and 3 months of observations).

Results: Statistically significant reduction in pain syndrome intensity and improvement in WOMAC index (all of its constituent parameters and total value), as well as clinical-laboratory indicators of OA activity were observed from the third month of the therapy and throughout the follow-up period, mainly in patients with early OA.

Conclusion: Course usage of Teraflex in an effective daily dose in patients with primary knee OA (especially in the early stages of the disease) in both the form of monotherapy and in combined with Ostenile, positively affects all clinical symptoms of knee OA: quickly and effectively reduces pain syndrome, stiffness, significantly improves functional condition of patients and as much as possible limits the usage of non-steroidal anti-inflammatory drugs.

Keywords: Primary osteoarthritis, knee joint, Teraflex, Ostenile, WOMAC index.

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Authors' information:

Rizoeva Oytillo Rustamovna
Applicant, Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University ORCID ID: 0000-002-9607-1916 SPIN: 1195-9010 E-mail: rizoevaojtillo@gmail.com

Saidov Yor Umarovich
Doctor of Medical Sciences, Head of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University Author ID: 844625 SPIN: 1842-1931 E-mail: erumarovich@mail.ru

Makhmudov Khayyom Ruziboevich
Candidate of Medical Sciences, Assistant of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University Author ID: 720314 SPIN: 1025-4700 E-mail: mahmudovkh@yandex.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Saidov Yor Umarovich
Doctor of Medical Sciences, Head of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (918) 694819

E-mail: erumarovich@mail.ru

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