Rheumatology
doi: 10.25005/2074-0581-2021-23-4-520-531
COMPARATIVE CLINICAL AND PHARMACOECONOMIC ANALYSIS OF THE EFFICACY OF MODERN COMBINATION THERAPY IN PATIENTS WITH PRIMARY KNEE OSTEOARTHRITIS, STAGES I-III

A.D. Davlatzoda1, Yo.U. Saidov1, Kh.R. Makhmudov1, R.J. Jamolova2

1Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Internal Medicine № 3, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study and comparatively evaluate the clinical and cost-effectiveness of modern structure/disease modifying anti- osteoarthritis drugs (S/ DMOADs) and hyaluronic acid (HLA) in modern intensive treatment of the primary knee osteoarthritis (KOA), stages I-III.

Methods: A comparative clinical and pharmacoeconomic analysis (PEA) of the effectiveness of a 6-month course of modern S/DMOADs (Structum®, Artra®) in combination with intra-articular HLA preparations (Ostenil®) and symptom-modifying drugs (SMDs) including non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids (GCs) was conducted in 103 patients with primary KOA, stages I-III.

Results: At the end of the study (after 6 months), in patients with primary KOA, stages I-III, a statistically significant improvement in all clinical, laboratory and instrumental parameters reflecting the severity and activity of the disease was verified. The gains were most clearly observed in patients with early stages of KOA (I-II).

Conclusion: Treatment with modern S/DMOADs (Structum®, Artra®) and HLA preparations (Ostenil®) and, symptomatically with (NSAIDs and GCs intraarticularly) in primary KOA patients, I-III stages demonstrates positive changes in all clinical and laboratory parameters (mainly in early stages of the disease). In addition, and no less critical, it considerably limits the use of NSAIDs. Therefore, treatment with Structum® of patients with early primary KOA is the most cost-effective.

Keywords: Primary osteoarthritis, knee joints, pharmacoeconomic analysis, Structum®, Artra®, Ostenil®, WOMAC index.

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Authors' information:

Davlatzoda Aslamkhon Davlat
Applicant of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-2239-7953
E-mail: aslamkhon.davlatzoda@gmail.com

Saidov Yor Umarovich
Doctor of Medical Sciences, Head of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-1432-9803
Author ID: 844625
SPIN: 1842-1931
E-mail: erumarovich@mail.ru

Makhmudov Khayom Ruziboevich
Candidate of Medical Sciences, Assistant of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-3583-9442
Author ID: 720314
SPIN: 1025-4700
E-mail: mahmudovkh@yandex.ru

Jamolova Rukhshona Jalolidinovna
Candidate of Medical Sciences, Associate Professor of the Department of Internal Medicine № 3, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-3327-0459
Author ID: 1073934
SPIN: 7258-1450
E-mail: ruha13@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Saidov Yor Umarovich
Doctor of Medical Sciences, Head of the Department of Propedeutics of Internal Diseases, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (918) 694819

E-mail: erumarovich@mail.ru

Materials on the topic:
  1. COMPARATIVE CLINICAL LABORATORY AND INSTRUMENTAL ASSESSMENT OF EFFECTIVENESS OF MONO- AND COMBINED THERAPY OF TERAFLEX WITH OSTENILE IN PATIENTS WITH PRIMARY KNEE OSTEOARTHRITIS
  2. PRIMARY KNEE OSTEOARTHRITIS: MODERN APPROACHES TO EARLY DIAGNOSIS AND EVALUATION OF COMORBIDITY
  3. COMPARATIVE ANALYSIS AND EVALUATION OF THE EFFECTIVENESS OF METHOTREXATE AND LEFLUNOMIDE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS IN THE CONDITIONS OF CAREFUL CONTROL BASED ON PRINCIPLES OF «TREAT TO TARGET» STRATEGY
  4. RELATIONSHIP BETWEEN ANEMIA AND HEART DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS
  5. ANALYSIS AND RATING ASSESSMENT OF INFORMATIVENESS OF CLASSIFICATION CRITERIA OF AMERICAN COLLEGE OF RHEUMATOLOGY/EUROPEAN LEAGUE AGAINST RHEUMATISM 2010 IN THE EARLY DIAGNOSTICS OF RHEUMATOID ARTHRITIS
  6. EVALUATION OF EFFECTIVENESS OF INFLUENCE OF THE SUBCUTANEOUS FORM OFMETHOTREXATUM TO THE LEVEL OF PRO-INFLAMMATORY CYTOKINEMIA AND THE MORPHOFUNCTIONAL STATE OF VASCULAR WALL IN PATIENTS WITH RHEUMATOID ARTHRITIS

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