Ophthalmology

doi: 10.25005/2074-0581-2020-22-4-535-541
ASSESSMENT OF EFFICACY AND SAFETY OF COMBINED MICROINVASIVE LASER-SURGICAL TREATMENT OF RHEGMATOGENOUS RETINAL DETACHMENT

A.V. Doga, D.O. Shkvorchenko, L.A. Kryl, M.R. Taevere

S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation

Objective: To evaluate the efficacy and safety of combined laser-surgical treatment of rhegmatogenous retinal detachment (RRD).

Methods: The 32 eyes from 32 patients with a local RRD due to horseshoe tear were enrolled. In addition to standard examination, all patients underwent multispectral laser scanning and wide-field optical coherence tomography (WFOCT) to determine the extention and localization of vitreoretinal tractions (VRT). All patients underwent the combined microinvasive laser-surgical technology of RRD treatment, including YAG-laser excision of the VRT area, pneumatic retinopexy, and barrier laser photocoagulation around the retinal tear after complete retinal attachment (2-3 days). The post-operative examination was performed on days 3 and 7, and in 3, 6, 12, 18, and 24 months. The follow-up period was 2 years.

Results: Retinal attachment was achieved in 30 patients (93.8%). The retina did not attach in 2 cases (6.4%) – in a patient with pseudophakia and in a patient who did not follow the recommendations on the proper head position after surgery. The recurrence of retinal detachment occurred in 2 cases (6.7%) as a result of the new tears formation in lower parts of the fundus periphery. The rest of the patients had a stable anatomical and functional result and no recurrence of the disease during the follow-up period. In 2 cases (6.7%) post-operative WFOCT revealed an additional zone of VRT in the adjacent areas to primary retinal tear which could not be visualized when retina was detached. These patients underwent additional barrier laser photocoagulation around revealed areas. No relapses occurred in these patients. Clinically insignificant retinal bleeding was observed in 4 cases (12.5%) during combined laser angiotomy. Full haemostasis was achieved by the 3-mirror contact lens pressure on the eye.

Conclusion: The presented technology demonstrates efficiency in 93.8% of cases after a single surgical intervention. The advantage of the technology is the complete elimination of VRT, as the main factor of the disease pathogenesis, which increases the anatomical efficacy of surgery and reduces the risk of recurrence. The micro-invasiveness and low trauma of this type of treatment help to minimize complications and accelerate the rehabilitation of patients. Further study of this technology with a large number of patients and a long follow-up period is required.

Keywords: Rhegmatogenous retinal detachment, wide-field optical coherence tomography, vitreoretinal traction, YAG-laser retinotomy, pneumatic retinopexy, barrier laser photocoagulation.

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References
  1. Mitry D, Charteris DG, Fleck B, Campbell H, Singh J. The epidemiology of rhegmatogenous retinal detachment: geographical variation and clinical associations. The British Journal of Ophthalmology. 2010;94(6):678-84. Available from: https://doi.org/10.1136/bjo.2009.157727
  2. Hisatomi T, Sakamoto T, Sonoda KH, Tsutsumi С, Qiao H, Enaida H, et al. Clearance of apoptotic photoreceptors: elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin alphavbeta3. Am J Pathol. 2003;162(6):1869-79. Available from: https://doi.org/10.1016/ s0002-9440(10)64321-0
  3. Arroyo JG, Yang L, Bula D, Chen DF. Photoreceptor apoptosis in human retinal detachment. Am J Ophthalmol. 2005;139(4):605-10. Available from: https:// doi.org/10.1016/j.ajo.2004.11.046
  4. Kuhn F, Aylward B. Rhegmatogenous retinal detachment: a reappraisal of its pathophysiology and treatment. Ophthalmic Res. 2014;51(1):15-31. Available from: https://doi.org/10.1159/000355077
  5. Hatef E, Sena DF, Fallano KA, Crews J, Do DV. Pneumatic retinopexy versus scleral buckle for repairing simple rhegmatogenous retinal detachments. Cochrane Database Syst Rev. 2015;5 (CD008350):1-27. Available from: https:// doi.org/10.1002/14651858
  6. Znaor L, Medic A, Binder S, Vicinovic A, Lovric JM, Puljak L. Pars plana vitrectomy versus scleral buckling for repairing simple rhegmatogenous retinal detachments. Cochrane Database Syst Rev. 2019;3(CD009562):1-10. Available from: https://doi.org/10.1002/14651858.CD009562.pub2
  7. Shah R, Byanju R, Pradhan S, Ranabhat S. Factors affecting the outcome of scleral buckling surgery for primary rhegmatogenous retinal detachment. J Ophthalmol. 2018:9016302. Available from: https://doi. org/10.1155/2018/9016302
  8. Haritoglou С, Brandlhuber U, Kampik A, Priglinger SG. Anatomic success of scleral buckling for rhegmatogenous retinal detachment – a retrospective study of 524 cases. Ophthalmologica. 2010;224(5):312-8. Available from: https://doi.org/10.1159/000298752
  9. Zaidi AA, Alvarado R, Irvine A. Pneumatic retinopexy: success rate and complications. Br J Ophthalmol. 2006;90(4):427-8. Available from: https://doi. org/10.1136/bjo.2005.075515
  10. Cankurtaran V, Citirik M, Simsek M, Tekin K, Mehmet YT. Anatomical and functional outcomes of scleral buckling versus primary vitrectomy in pseudophakic retinal detachment. Bosn J Basic Med Sci. 2017;17(1):74-80. Available from: https://doi.org/10.17305/bjbms.2017.1560
  11. Lincoff H, Lincoff A, Stopa M. Systematic review of efficacy and safety of surgery for primary retinal detachment. In: Kreissig I. (eds) Primary Retinal Detachment. Berlin, Heidelberg: Springer Publishers; 2005. p. 161-75. Available from: https://doi.org/10.1007/3-540-26801-4_8
  12. Kryl LA, Shkvorchenko DO, Buryakov DA. Sposob mikroinvazivnogo kombinirovannogo lazerkhirurgicheskogo lecheniya lokal’noy otsloyki setchatki vsledstvie klapannogo razryv [Technology of combined laser-surgical treatment of retinal detachment due to horseshoe tear]. Patent RF na izobretenie № 2653818. 14.05.2018.
  13. Doga AV, Shkvorchenko DO, Kryl LA, Buryakov DA, Bayzulaeva MR. Analiz rezul’tatov primeneniya kombinirovannogo mikroinvazivnogo lazer-khirurgicheskogo lecheniya patsientov s lokal’nymi otsloykami setchatki [Evaluation of the treatment results in patients with rhegmatogenous retinal detachment treated by combined microinvasive laser-surgical technology]. Sovremennye tekhnologii v oftal’mologii. 2019;1:363-8. Available from: https://doi. org/10.25276/2312-4911-2019-1-363-368
  14. Doga AV, Kryl LA, Taevere MR, Klepinina OB, Buryakov DA. Sposob opredeleniya zony lazernogo vozdeystviya pri provedenii retinotomii v khode lazerkhirurgicheskogo lecheniya lokal’noy regmatogennoy ot-sloyki setchatki [Method for determining the zone of laser exposure during retinotomy for laser-surgical treatment of rhegmatogenous retinal detachment]. Patent RF na izobretenie № RU 2718316 C1. 01.04.2020.
  15. Doga AV, Kryl LA, Taevere MR, Buryakov DA. Otsenka vzaimosvyazi formy klapannogo razryva i granits vitreoretinal’nogo srashcheniya pri pomoshchi opticheskoy kogerentnoy tomografii i mul’tispektral’nogo lazernogo skanirovaniya [The assessment of relationship between the horseshoe tear shape and the localization of vitreoretinal traction by wide-angle spectral optical coherence tomography and multispectral laser scanning]. Sovremennye tekhnologii v oftal’mologii. 2020;1:306-9. Available from: https://doi. org/10.25276/2312-4911-2020-2-306-309
  16. Martínez-Mujica M-T, Retamal J, González R. Scleral buckle versus pneumatic retinopexy for rhegmatogenous retinal detachments. Medwave. 2018;18(6):e7278. Available from: https://doi.org/10.5867/medwave. 2018.06.7277
  17. Hillier RJ, Felfeli T, Berger AR, Wong D, Altomare F, Dai D, et al. The pneumatic retinopexy versus vitrectomy for the management of primary rhegmatogenous retinal detachment outcomes randomized trial (PIVOT). Ophthalmology. 2019;126(4):531-9. Available from: https://doi.org/10.1016/j. ophtha.2018.11.014
  18. Tornambe PE. Pneumatic retinopexy: the evolution of case selection and surgical technique. A twelve-year study of 302 eyes. Trans Am Ophthalmol Soc. 1997;95:551-78.
  19. Verena VR, Bamakrid M, Jin S, Paracha Q, Kim D, Marafon S, et al. Pneumatic retinopexy in patients with primary rhegmatogenous retinal detachment meeting PIVOT trial criteria. Ophthalmol Retina. 2020;S2468-6530(20):30307- 9. Available from: https://doi.org/10.1016/j.oret.2020.07.022
  20. Eter N, Böker T, Spitznas M. Long-term results of pneumatic retinopexy. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2000;238(8):677- 81. Available from: https://doi.org/10.1007/s004170000167

Authors' information:


Doga Aleksandr Viktorovich
Doctor of Medical Sciences, Full Professor, Deputy CEO for Scientific and Clinical Work, S. Fyodorov Eye Microsurgery Federal State Institution
Researcher ID: U-4263-2019
ORCID ID: 0000-0003-2519-8941
SPIN: 6460-1726
Author ID: 184054
E-mail: alexander_doga@mail.ru

Shkvorchenko Dmitry Olegovich
Candidate of Medical Sciences, Deputy Chief Physician, S. Fyodorov Eye Microsurgery Federal State Institution
ORCID ID: 0000-0002-0176-928X
SPIN: 3094-1973
Author ID: 663870
E-mail: shkvor@mail.ru

Kryl Leonid Anatolyevich
Candidate of Medical Sciences, Senior Researcher of the Department of Laser Retinal Surgery, S. Fyodorov Eye Microsurgery Federal State Institution
ORCID ID: 0000-0003-1125-1692
SPIN: 5777-4657
Author ID: 848265
E-mail: doctor-leonid@inbox.ru

Taevere Mariyam Ramazanovna
Postgraduate Student of the Department of Laser Retinal Surgery, S. Fyodorov Eye Microsurgery Federal State Institution
ORCID ID: 0000-0003-1013-6924
SPIN: 5252-6779
Author ID: 1046067
E-mail: taeveremr@gmail.com

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:


Taevere Mariyam Ramazanovna
Postgraduate Student of the Department of Laser Retinal Surgery, S. Fyodorov Eye Microsurgery Federal State Institution

127486, Russian Federation, Moscow, Beskudnikovskiy blvd., 59a

Tel.: +7 (916) 0173038

E-mail: taeveremr@gmail.com

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