Endocrinology
doi: 10.25005/2074-0581-2021-23-1-67-72
BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN WITH TYPE 2 diabetes mellitus in THE HIGH FERTILITY REGION

Sh.S. Anvarova, M.E. Muzafarova

Department of Endocrinology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the state of the sceletal system in type 2 diabetes mellitus (T2DM) in postmenopausal women, taking into account parity.

Methods: 110 women with T2DM (55 patients with normal and 55 with high parity) were examined. The control group consisted of 55 high parity women who did not suffer from T2DM. The parameters of phosphorus-calcium metabolism and vitamin D were studied. To assess the possible loss of bone tissue, the method of dual-energy X-ray absorptiometry was used.

Results: The data obtained indicate that the content of total calcium, phosphorus and vitamin D was statistically significantly reduced in T2DM patients with high parity compared with the control group (p<0.05), while in relation to the concentration of alkaline phosphatase, significant no differences were noted (p>0.05). When comparing bone mineral density (BMD) values in T2DM women with normal and high parity, statistically significant differences were noted in relation to the lumbar spine (p<0.05) and the distal forearm (p<0.01) (according to the T-score) and distal forearm (p<0.001) (according to the Z-score). When comparing BMD in the control group and T2DM women with high parity, statistically significant differences were found only in relation to the lumbar spine (p<0.05) (according to the T-score).

Conclusion: High parity is one of the additional risk factors for the development of osteopenic syndrome in T2DM postmenopausal women. The association of multiparity with sub- and decompensated T2DM has an important prognostic value in impaired bone mineral density.

Keywords: Osteoporosis , bone mineral density, type 2 diabetes mellitus, menopause, high fertility region.

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Authors' information:

Anvarova Shakardzon Saidoromovna
Doctor of Medical Sciences, Full Professor, Professor of the Department of Endocrinology, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-8806-919X
SPIN: 3529-0234
Author ID: 1075066
E-mail: anvarova43@mail.ru

Muzafarova Mekhrinigor Emomkhusaynovna
PhD Student, Department of Endocrinology, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-7465-5646
E-mail: mekhrinigorm@bk.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Muzafarova Mekhrinigor Emomkhusaynovna
PhD Student, Department of Endocrinology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (777) 004646

E-mail: mekhrinigorm@bk.ru

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