REVIEW ARTICLE

Obstetrics and Gynecology

doi: 10.25005/2074-0581-2022-24-4-502-513
FOLATE METABOLISM IN PREGNANCY

Z.D. Salimova, M.F. Dodkhoeva

Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

The literature review examines the data on the role of folic acid in the human body, especially in women of the reproductive period. An analysis of research studies was conducted to assess the effect of folic acid and folate deficiency on organogenesis and placental formation. In addition, folate deficiency is associated with severe pregnancy complications, including placental abruption, spontaneous miscarriages, intrauterine growth retardation, and preeclampsia. Also, it plays a role in developing congenital malformations of the cardiovascular, nervous, visual and musculoskeletal systems. It was found that with hyperhomocysteinemia, the risk of complications with a self-enhancing cascade of pathological changes during the gestation period increases significantly. In this regard, when planning a pregnancy, it is recommended that all women examine the levels of homocysteine concentration. It is also mandatory to investigate the levels of homocysteine concentration in women with a history of obstetric complications – placental abruption, miscarriage, and the family history of stroke, myocardial infarction and thrombosis in relatives below the age of 45-50 years.

Keywords: Folic acid, folates, folate deficiency, hyperhomocysteinemia, pregnancy, miscarriage.

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Author information:


Salimova Zumrat Dzhamshedovna
Postgraduate Student of the Department of Obstetrics and Gynecology № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-8276-8678
E-mail: zumrat.9595@mail.ru

Dodkhoeva Munavvara Fayzulloevna
Academician of National Academy of Sciences of the Republic of Tajikistan, Doctor of Medical Sciences, Full Professor, Professor of the Department of Obstetrics and Ginecology № 1, Avicenna Tajik State Medical University
Researcher ID: AAC-4784-2019
ORCID ID: 0000-0001-9373-4318
SPIN: 9749-6174
Author ID: 313026
E-mail: dodkho2008@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

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Dodkhoeva Munavvara Fayzulloevna
Academician of National Academy of Sciences of the Republic of Tajikistan, Doctor of Medical Sciences, Full Professor, Professor of the Department of Obstetrics and Ginecology № 1, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (918) 612606

E-mail: dodkho2008@mail.ru

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