General Surgery

doi: 10.25005/2074-0581-2023-25-3-390-399
MODERN ASPECTS OF NONPARASITIC LIVER CYSTS

I.A. Kopytin1, V.V. Ivanov1, V.B. Filimonov1, G.Y. Zhuravlyov2, V.S. Fomin3, I.V. Abramov1

1Department of Urology with a Course of Surgical Diseases, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation
2Department of Faculty Surgery, Tambov Medical Institute, Tambov, Russian Federation
3Department of Surgical Diseases and Clinical Angiology, Moscow State Medical and Dental University named after A.I. Evdokimov, Moscow, Russian Federation

Objective: The relevance of nonparasitic cysts of the liver (NPCL) is related to their steadily increasing incidence, high recurrence rates, delayed diagnosis, and potential complications. In general, hepatic cysts (HCs) are classified into several types, including simple and complex, false and true. Simple cysts are mainly congenital but also occur in polycystic liver disease. Complex cysts include mucinous neoplasms, echinococcal cysts, hemorrhagic cysts, cystic hepatocellular carcinoma, and other rare lesions. Nonparasitic cystic liver lesions do not usually cause symptoms, and their characteristics are not specific. In 15% of cases, nonspecific signs (flatulence, nausea, dyspepsia) accompany pain. Diagnosis of NPCL is based on data from ultrasound, CT, or MRI of the abdominal organs. There still needs to be a consensus on surgical treatment indications or the effectiveness and feasibility of its various methods. Many surgical interventions for NPCL treatment include puncture drainage, multiple minimally invasive (laparoscopic) surgery options, and open methods. In clinical practice, laparoscopic fenestration, associated with fewer complications and faster recovery, has become widespread. However, significant progress has yet to be achieved in reducing NPCL recurrence rates despite advances in surgical treatment. Therefore, multiple studies are underway to improve treatment options for this medical condition.

Keywords: Liver, cyst, nonparasitic cyst, pseudocyst, laparoscopic fenestration.

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References
  1. Zarivchatskiy MF, Pankov KI, Kamenskikh ED, Mugatarov II, Smetanin DV. Mini-invazivnye tekhnologii pri lechenii neparazitarnykh kist pecheni [Mini-invasive techniques in treatment of nonparasitic hepatic cysts]. Permskiy meditsinskiy zhurnal. 2013;30(1):5-10
  2. Dietrich CF, Chiorean L, Potthoff A, Ignee A, Cui X, Sparchez Z. Percutaneous sclerotherapy of liver and renal cysts, comments on the EFSUMB guidelines. Z Gastroenterol. 2016;54(2):155-66. https://doi.org/10.1055/s-0041-106594
  3. Alshaikhli A, Al-Hillan A. Liver Cystic Disease. 2022 Oct 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan
  4. Lasagni A, Cadamuro M, Morana G, Fabris L, Strazzabosco M. Fibrocystic liver disease: Novel concepts and translational perspectives. Transl Gastroenterol Hepatol. 2021;6:26. https://doi.org/10.21037/tgh-2020-04
  5. Murunova YuN, Darvin VV. Lechebno-diagnosticheskaya taktika vedeniya patsientov s neparazitarnymi kistami pecheni [Therapeutic and diagnostic tactics for the management of patients with non-parasitic liver cysts]. Ural'skiy meditsinskiy zhurnal. 2018;(12):136-40. https://doi.org/10.25694/ URMJ.2018.12.37
  6. Bernts LHP, Echternach SG, Kievit W, Rosman C, Drenth JPH. Clinical response after laparoscopic fenestration of symptomatic hepatic cysts: A systematic review and meta-analysis. Surg Endosc. 2019;33(3):691-704. https://doi. org/10.1007/s00464-018-6490-8
  7. Santos-Laso A, Izquierdo-Sánchez L, Lee-Law PY, Perugorria MJ, Marzioni M, Marin JJ, et al. New advances in polycystic liver diseases. Semin Liver Dis. 2017;37(1):45-55. https://doi.org/10.1055/s-0036-1597817
  8. Norcia LF, Watanabe EM, Hamamoto Filho PT, Hasimoto CN, Pelafsky L, de Oliveira WK, et al. Polycystic liver disease: Pathophysiology, diagnosis and treatment. Hepat Med. 2022;14:135-61. https://doi.org/10.2147/HMER.S377530
  9. Zhang JY, Liu Y, Liu HY, Chen L, Su DW, Wang YB. Comparison of the recurrence rates of nonparasitic hepatic cysts treated with laparoscopy or with open fenestration: A meta-analysis. Surg Laparosc Endosc Percutan Tech. 2018;28(2):67- 72. https://doi.org/10.1097/SLE.0000000000000516
  10. Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology. ACG clinical guideline: The diagnosis and management of focal liver lesions. Am J Gastroenterol. 2014;109(9):1328-47. https://doi.org/10.1038/ajg.2014.213
  11. Murunova YuN, Darvin VV, Lysak MM. Khirurgicheskaya taktika u patsientov s neparazitarnymi kistami pecheni [Surgical tactics in patients with non-parasitic liver cysts]. Vestnik SurGU. Meditsina. 2018;1:6-10
  12. Olaizola P, Rodrigues PM, Caballero-Camino FJ, Izquierdo-Sanchez L, Aspichueta P, Bujanda L, et al. Genetics, pathobiology and therapeutic opportunities of polycystic liver disease. Nat Rev Gastroenterol Hepatol. 2022;19(9):585-604. https://doi.org/10.1038/s41575-022-00617-7
  13. Chen PL, Zou JM, Jin DS. Comparison of three treatment methods for symptomatic non-parasitic hepatic cysts. Mod Hosp. 2012;12:34-5.
  14. Macedo FI. Current management of noninfectious hepatic cystic lesions: A review of the literature. World J Hepatol. 2013;5(9):462-9. https://doi. org/10.4254/wjh.v5.i9.462
  15. Zhivaeva EV, Freind GG. Dizontogeneticheskie kisty pecheni: pato- i morfogenez [Dysontogenetic liver cysts: Patho- and morphogenesis]. Dokazatel'naya gastroenterologiya. 2020;9(3):39‑46.
  16. Stănescu CA, Păduraru DN, Cirimbei C, Brătucu E. The laparoscopic management of simple hepatic cysts. J Med Life. 2015;8(3):342-5.
  17. Aapkes SE, Bernts LHP, Barten TRM, van den Berg M, Gansevoort RT, Drenth JPH. Estrogens in polycystic liver disease: A target for future therapies? Liver Int. 2021;41(9):2009-19. https://doi.org/10.1111/liv.14986
  18. Ferrer Inaebnit E, Molina Romero FX, Segura Sampedro JJ, González Argenté X, Morón Canis JM. A review of the diagnosis and management of liver hydatid cyst. Rev Esp Enferm Dig. 2022;114(1):35-41. https://doi.org/10.17235/ reed.2021.7896/2021
  19. van Aerts RMM, van de Laarschot LFM, Banales JM, Drenth JPH. Clinical management of polycystic liver disease. J Hepatol. 2018;68(4):827-37. https://doi. org/10.1016/j.jhep.2017.11.024
  20. de Reuver P, van der Walt I, Albania M, Samra JS, Hugh TJ. Long-term outcomes and quality of life after surgical or conservative treatment of benign simple liver cysts. Surg Endosc. 2018;32(1):105-13. https://doi.org/10.1007/s00464- 017-5645-3
  21. Loehe F, Globke B, Marnoto R, Bruns CJ, Graeb C, Winter H, Jauch KW, Angele MK. Long-term results after surgical treatment of nonparasitic hepatic cysts. Am J Surg. 2010;200(1):23-31. https://doi.org/10.1016/j.amjsurg.2009.06.031
  22. Boerrigter MM, Bongers EMHF, Lugtenberg D, Nevens F, Drenth JPH. Polycystic liver disease genes: Practical considerations for genetic testing. Eur J Med Genet. 2021;64(3):104160. https://doi.org/10.1016/j.ejmg.2021.104160
  23. Murunova YuN, Darvin VV. Rol' maloinvazivnykh tekhnologiy v khirurgicheskom lechenii neparazitarnykh kist pecheni [The role of minimally invasive technologies in the surgical treatment of non-parasitic liver cysts]. Kubanskiy nauchniy meditsinskiy vestnik. 2017;(3):66-70. https://doi.org/10.25207/1608-6228- 2017-24-3-66-70
  24. Masyuk TV, Masyuk AI, LaRusso NF. Polycystic liver disease: Advances in understanding and treatment. Annu Rev Pathol. 2022;17:251-69. https://doi. org/10.1146/annurev-pathol-042320-121247
  25. Akhaladze GG, Nanetashvili MG, Chevokin AYu, Galperin EI. Khirurgicheskoe lechenie neparazitarnykh kist pecheni [Surgical treatment of non-parasitic liver cysts]. Annaly khirurgicheskoy gepatologii. 1999;4(1):29-33.
  26. Mavilia MG, Pakala T, Molina M, Wu GY. Differentiating cystic liver lesions: A review of imaging modalities, diagnosis and management. J Clin Transl Hepatol. 2018;6(2):208-16. https://doi.org/10.14218/JCTH.2017.00069
  27. Tolstikov AP, Zakharova AV. Minimal'no invazivnaya khirurgiya v lechenii bol'nykh s neparazitarnymi kistami pecheni [Minimally invasive surgery in the treatment of patients with non-parasitic liver cysts]. Meditsinskiy al'manakh. 2010;1:151-2.
  28. Zarivchatskiy MF, Pirozhnikov OYu, Pankov KI, Mugatarov IN, Smetanin DV. Printsipy lecheniya neparazitarnykh kist pecheni [Principles of treatment of non-parasitic liver cysts]. Permskiy meditsinskiy zhurnal. 2011;28(1):5-9
  29. Furumaya A, van Rosmalen BV, de Graeff JJ, Haring MPD, de Meijer VE, van Gulik TM, et al; Dutch Benign Liver Tumor Group. Systematic review on percutaneous aspiration and sclerotherapy versus surgery in symptomatic simple hepatic cysts. HPB (Oxford). 2021;23(1):11-24. https://doi.org/10.1016/j. hpb.2020.07.005
  30. Zhavoronkova OI. Lechenie neparazitarnykh kist pecheni bolee 10 sm v diametre [Treatment of non-parasitic liver cysts more than 10 cm in diameter] Annaly khirurgicheskoy gepatologii. 2007;2:116-22
  31. Gomez A, Wisneski AD, Luu HY, Hirose K, Roberts JP, Hirose R, et al. Contemporary management of hepatic cyst disease: Techniques and outcomes at a tertiary hepatobiliary center. J Gastrointest Surg. 2021;25(1):77-84. https:// doi.org/10.1007/s11605-020-04821-1
  32. Leombroni M, Buca D, Celentano C, Liberati M, Bascietto F, Gustapane S, et al. Outcomes associated with fetal hepatobiliary cysts: Systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2017;50(2):167-74. https://doi. org/10.1002/uog.17244
  33. Manucharov AA, Smolkina AV. Optimizatsiya khirurgicheskogo lecheniya bol'nykh neparazitarnymi kistami pecheni [Optimization of surgical treatment of patients with non-parasitic liver cysts]. Ul'yanovskiy mediko-biologicheskiy zhurnal. 2015;1:78-84
  34. Shimizu T, Yoshioka M, Kaneya Y, Kanda T, Aoki Y, Kondo R, et al. Management of simple hepatic cyst. J Nippon Med Sch. 2022;89(1):2-8. https://doi. org/10.1272/jnms.JNMS.2022_89-115
  35. Roediger R, Dieterich D, Chanumolu P, Deshpande P. Polycystic kidney/liver disease. Clin Liver Dis. 2022;26(2):229-43. https://doi.org/10.1016/j. cld.2022.01.009
  36. Zhavoronkova OI, Gavrilin AV, Ionkin DA, Melekhina OV, Andreenkov SS. Vklad interventsionnoy sonografii v razvitie organosokhranyayushchikh tekhnologiy Instituta khirurgii im. A.V. Vishnevskogo pri lechenii patsientov s ochagovymi porazheniyami pecheni i selezyonki [The contribution of interventional sonography to the development of organ-preserving technologies in A.V. Vishnevskiy Institute of Surgery in the treatment of patients with focal lesions of the liver and spleen]. Novosti khirurgii. 2011:19(1):94-102
  37. Debs T, Kassir R, Reccia I, Elias B, Ben Amor I, Iannelli A, et al. Technical challenges in treating recurrent non-parasitic hepatic cysts. Int J Surg. 2016;25:44-8. https://doi.org/10.1016/j.ijsu.2015.11.051
  38. Khan S, Dennison A, Garcea G. Medical therapy for polycystic liver disease. Ann R Coll Surg Engl. 2016;98(1):18-23. https://doi.org/10.1308/rcsann.2016.0023
  39. Manterola C, Otzen T; MINCIR Group. Laparoscopic surgery in nonparasitic cysts of the liver: Results observed in a series of consecutive cases. Surg Laparosc Endosc Percutan Tech. 2016;26(4):308-12. https://doi.org/10.1097/ SLE.0000000000000303
  40. Antonacci N, Ricci C, Taffurelli G, Casadei R, Minni F. Systematic review of laparoscopic versus open surgery in the treatment of non-parasitic liver cysts. Updates Surg. 2014;66(4):231-8. https://doi.org/10.1007/s13304-014-0270-3
  41. Kisiel A, Vass DG, Navarro A, John AK, Isaac J, Marudanayagam R, et al. Longterm patient-reported outcomes after laparoscopic fenestration of symptomatic liver cysts. Surg Laparosc Endosc Percutan Tech. 2017;27(4):e80-e82. https://doi.org/10.1097/SLE.0000000000000441

Authors' information:


Kopytin Ivan Aleksandrovich,
Postgraduate Student, Department of Urology with a Course of Surgical Diseases, Ryazan State Medical University named after Academician I.P. Pavlov
ORCID ID: 0000-0003-2157-1219
E-mail: ivan_kopytin@bk.ru

Ivanov Vladislav Valerievich,
Candidate of Medical Sciences, Associate Professor, Department of Urology with a Course of Surgical Diseases, Ryazan State Medical University named after Academician I.P. Pavlov
ORCID ID: 0000-0002-4333-1067
E-mail: 990089@mail.ru

Filimonov Viktor Borisovich,
Doctor of Medical Sciences, Associate Professor, Department of Urology with a Course of Surgical Diseases, Ryazan State Medical University named after Academician I.P. Pavlov
ORCID ID: 0000-0002-2199-0715
E-mail: Filimonov1974@mail.ru

Zhuravlyov German Yurievich,
Doctor of Medical Sciences, Professor of the Department of Faculty Surgery, Tambov Medical Institute
ORCID ID: 0000-0003-3359-2551
E-mail: zhgy-surg@mail.ru

Fomin Vladimir Sergeevich,
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases and Clinical Angiology, Moscow State Medical and Dental University named after A.I. Evdokimov
ORCID ID: 0000-0002-1594-4704
E-mail: wlfomin83@gmail.com

Abramov Igor Vladimirovich,
Postgraduate Student,
Department of Urology with a Course of Surgical Diseases, Ryazan State Medical University named after Academician I.P. Pavlov
ORCID ID: 0000-0003-0204-5627
E-mail: Igo35049534@bk.ru

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Conflicts of interest: No conflict

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Kopytin Ivan Aleksandrovich
Postgraduate Student, Department of Urology with a Course of Surgical Diseases, Ryazan State Medical University named after Academician I.P. Pavlov

390026, Russian Federation, Ryazan, Vysokovoltnaya str., 9

Tel.: +7 (920) 9996988

E-mail: ivan_kopytin@bk.ru

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