Pathology
doi: 10.25005/2074-0581-2023-25-4-520-526
EXPERIMENTAL PERICARDITIS

E.A. LOZOVSKAYA, N.N. DREMINA, S.B. NIKIFOROV, I.A. SHURYGINA

Irkutsk Scientific Center for Surgery and Traumatology, Irkutsk, Russian Federation

Methods: The article discusses a pressing issue in cardiac surgery – the development of cicatricial adhesions and complications that arise from adhesive pericarditis, which can transform into a more severe condition known as constrictive pericarditis. The article also delves into the challenges of performing repeated cardiac surgery, the factors that trigger the adhesive process in the pericardium, and the etiopathogenetic mechanisms of fibrogenesis. These mechanisms involve the participation of active immune cells and the release of proinflammatory cytokines. Specifically, the article examines the features involved in the development of constrictive pericarditis, focusing on the cellular and molecular aspects of pericardial remodeling. It also evaluates the surgical and therapeutic measures currently used to prevent complications after cardiac surgery. Using original biological test systems involving experimental animals is advocated for a better understanding of the mechanisms underlying adhesive pericarditis after cardiac surgery and the development of effective prevention strategies. A range of experimental models of adhesions caused by pericarditis during open-heart surgery in mice is presented in this paper. The models include talc-induced pericarditis in mice, pigs, dogs, and rabbits, induced through the intrapericardial injection of Zymosan A, a known activator of the nucleotide-binding domain leucine-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome. Furthermore, the paper also covers mechanical methods of activation of pericarditis. These experimental models will help researchers explore the potential of new anti-adhesion drug molecules, which can be used in cardiac surgery.

Keywords: Cardiac surgery, constrictive pericarditis, mechanisms of fibrogenesis, prevention of pericarditis, experimental models of pericarditis.

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Authors' information:

Lozovskaya Evgeniya Aleksandrovna,
Сandidate of Veterinary Sciences, Senior Researcher of the Scientific Department of Experimental Surgery with a Vivarium, Irkutsk Scientific Center for Surgery and Traumatology
ORCID ID: 0000-0003-3851-128X
SPIN: 5547-3856
Author ID: 965503
E-mail: molodegny31@mail.ru

Dremina Natalya Nikolaevna,
Сandidate of Biological Sciences, Senior Researcher of the Laboratory of Сellular Technologies and Regenerative Medicine, Irkutsk Scientific Center for Surgery and Traumatology
Scopus ID: 36243115900
ORCID ID: 0000-0002-2540-4525
SPIN: 8038-3583
Author ID: 605510
E-mail: drema76@mail.ru

Nikiforov Sergey Borisovich,
Doctor of Medical Sciences, Leading Researcher of the Scientific Department of Experimental Surgery with a Vivarium, Irkutsk Scientific Center for Surgery and Traumatology
ORCID ID: 0000-0002-0486-9235
SPIN: 7451-4149
Author ID: 395777
E-mail: telomer@mail.ru

Shurygina Irina Aleksandrovna,
Doctor of Medical Sciences, Full Professor, Deputy Director for Research, Irkutsk Scientific Center of Surgery and Traumatology
Researcher ID: B-4059-2018
Scopus ID: 36244455300
ORCID ID: 0000-0003-3980-050X
SPIN: 6745-5426
Author ID: 161435
E-mail: irinashurygina@gmail.com

Information about support in the form of grants, equipment, medications

The research was carried out in accordance with the research plan of Irkutsk Scientific Center of Surgery and Traumatology (state registration number – 122022200212-6). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Lozovskaya Evgeniya Aleksandrovna
Сandidate of Veterinary Sciences, Senior Researcher of the Scientific Department of Experimental Surgery with a Vivarium, Irkutsk Scientific Center for Surgery and Traumatology

664003, Russian Federation, Irkutsk, Bortsov Revolyutsii str., 1

Tel.: +7 (3952) 290336

E-mail: molodegny31@mail.ru

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