EXPERIMENTAL RESEARCH
Pathology
doi: 10.25005/2074-0581-2025-27-3-683-694
EFFECTS OF POLYPHENOLIC COMPOUNDS ON BIOCHEMICAL PROFILE AND RENAL MORPHOLOGY IN THE CONTEXT OF EXPERIMENTAL METABOLIC SYNDROME

A.A. SHEVANDOVA1,2, L.O. AMETOVA3, T.P. MAKALISH1, I.V. CHERNOUSOVA4, L.E. SOROKINA1,5, A.A. PISAREV3, I.I. FOMOCHKINA3

1Central Research Laboratory, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation
2Laboratory of Analytical Research, Innovative and Resource-Saving Technologies, All-Russian National Research Institute of Viticulture and Winemaking “Magarach” of the Russian Academy of Sciences, Yalta, Russian Federation
3Department of Basic and Clinical Pharmacology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation
4Laboratory of Functional Products of Grape Processing, All-Russian National Research Institute of Viticulture and Winemaking “Magarach” of the Russian Academy of Sciences, Yalta, Russian Federation
5Laboratory of Cytology, Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation

Objective: To study the effect of polyphenolic compounds on biochemical profile and renal morphology in the context of experimental metabolic syndrome (MetS).

Methods: An experimental study was conducted involving 50 Wistar rats, utilizing a high fructose diet to simulate metabolic syndrome (MetS). The animals were grouped into groups of 10 based on the treatments they received, which included Edarbi (azilsartan) and polyphenol‐rich extracts from grape cane and seeds. There was also a comparison group consisting of rats with MetS that did not receive any treatment, as well as a control group of healthy intact animals. Biochemical and morphological methods were employed to evaluate the effectiveness of the various therapeutic strategies.

Results: Polyphenol‐rich extracts derived from grape cane and seeds, along with angiotensin II type 1 receptor blockers, such as Edarbi (azilsartan), have demonstrated a beneficial effect in preventing the onset of MetS.

Conclusion: The results of the study suggest that polyphenol‐rich extracts derived from grape seeds and cane may offer nephroprotective benefits in the context of MetS. Therefore, the study recommends these extracts for clinical trials as part of a comprehensive treatment approach for metabolic nephropathy and other kidney-related diseases linked to metabolic disorders.

Keywords: Metabolic syndrome, nephropathy, polyphenols, resveratrol.

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Authors' information:

Shevandova Alina Alekseevna,
Junior Researcher, Central Research Laboratory, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University; Junior Researcher, Laboratory of Analytical Research, Innovative and Resource-Saving Technologies, All-Russian National Research Institute of Viticulture and Winemaking “Magarach” of the Russian Academy of Sciences
Researcher ID: ABA-5691-2020
Scopus ID: 57218800193
ORCID ID: 0000-0002-9448-6034
SPIN: 6199-4876
Author ID: 1058876
E-mail: shevandova_a_a@mail.ru

Ametova Lilia Osmanovna,
Student, Department of Basic and Clinical Pharmacology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University
ORCID ID: 0000-0003-1496-4954
SPIN: 5630-9650
Author ID: 1197510
E-mail: ametova-lilya@bk.ru

Makalish Tatyana Pavlovna,
Leading Researcher, Central Research Laboratory, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University
Researcher ID: A-9786-201
Scopus ID: 57204727287
ORCID ID: 0000-0003-1884-2620
SPIN: 1523-5893
Author ID: 891400
E-mail: makalisht@mail.ru

Chernousova Inna Vladimirovna,
Candidate of Technical Sciences, Leading Researcher, Laboratory of Functional Products of Grape Processing, All-Russian National Research Institute of Viticulture and Winemaking "Magarach" of the Russian Academy of Sciences Researcher ID: AAU-2756-2021
Scopus ID: 57189730736
ORCID ID: 0000-0001-5374-7683
SPIN: 5079-7416
Author ID: 794021
E-mail: cherninna1@mail.ru

Sorokina Leya Evgenievna,
Junior Researcher, Central Research Laboratory, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University; Junior Researcher, Laboratory of Cytology, Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation
Researcher ID: AAD-9306-2021
Scopus ID: 57209735259
ORCID ID: 0000-0002-1862-6816
SPIN: 5934-0679
Author ID: 988747
E-mail: leya.sorokina@mail.ru

Pisarev Anatoly Arkadyevich,
Candidate of Medical sciences, Associate Professor, Department of Basic and Clinical Pharmacology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University
ORCID ID: 0000-0002-9204-5198
SPIN: 7528-1674
Author ID: 900078
E-mail: anatolijpisarev2009@yandex.ru

Fomochkina Irina Ivanovna,
Doctor of Medical Sciences, Full Professor, Depu-ty Director for Scientific and Innovative Activities, Head of the Department of Basic and Clinical Pharmacology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University
Researcher ID: AAC-7912-2022
Scopus ID: 24449143700
ORCID ID: 0000-0003-3065-5748
SPIN: 3281-4940
Author ID: 802468
E-mail: fomochkina_i@mail.ru

Information about support in the form of grants, equipment, medications

This study received support from the Russian Science Foundation under grant number 24-25-20132. For more information, please visit https://rscf.ru/project/24-25-20132/. The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Sorokina Leya Evgenievna
Junior Researcher, Central Research Laboratory, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University; Junior Researcher, Laboratory of Cytology, Academician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation

295051, Russian Federation, Simferopol, Lenin Blvd., 5/7

Tel.: +7 (978) 2094673

E-mail: leya.sorokina@mail.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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