Pediatrics
doi: 10.25005/2074-0581-2018-20-1-69-72
THE INCIDENCE OF LEUKAEMIA IN KYRGYZSTAN IN CHILDREN UNDER 5 YEARS
Department of Surgical Diseases, International Higher School of Medicine, Bishkek, Kyrgyz Republic
Objective: To study the incidence rates of acute lymphoblastic and myeloblastic leukaemia in the age category of children under 5 years.
Methods: For the period 2006-2016 were registered 175 cases of acute leucosis in the age category under 5 years in Kyrgyzstan. In 144 cases (82.9%) there was acute lymphoblastic and in 30 cases (17.1%) acute myeloblastic leukaemia.
Results: The incidence rates in the age group from one to 5 years, in both groups had higher rates compared to the age of up to 1 year. For boys under 1 year the incidence was 12.14 and at the age of 1 to 5 years – 30.76 per 1 million population, for girls these figures were equal to 7.89 and 17.76 respectively. In contrast to the incidence of acute lymphoblastic leukaemia, morbidity of the incidence of acute myeloblastic leukaemia in rural areas turned out to be more than inhabitants of the city, amounting to 5.47 and 2.88 per million people, respectively.
Conclusion: The incidence of acute leukaemia in the age category under 1 year is low. The highest incidence rates are registered in the age category from one to 5 years. The incidence of acute leukaemia in boys was higher than that of girls.
Keywords: Acute lymphoblastic leukaemia, acute myeloblastic leukaemia, infant leukaemia, standardized incidence rate.
References
- Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia in children: a review. Environ Health Perspect. 2007;115:138-45.
- Hakulinen T, Seppa K, Lambert PC. Choosing the relative survival method for cancer survival estimation. Eur J Cancer.2011;47:2202-10.
- Meulepas JM, Ronckers CM, Smets AM, NievelsteinRA, Jahnen A, Lee C, et al. Leukemia and brain tumors among children after radiation ex-posure from CT scans: design and methodological opportunities of the Dutch Pediatric CT Study. European Journal of Epidemiolo-gy. 2014;29(4):293-301.
- Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, et al. Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California. Environ Health Perspect. 2014;122(10):1110-6.
- Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia Net. Blood. 2010;115(3):453-74.
- Estey EH. Prognostic factors in acute myelogenous leukemia. Leukemia. 2015;3:670-2.
- Filippini T, Heck JE, Malagoli C, Del Giovane C, Vinceti M. A review and meta-analysis of outdoor air pollution and risk of childhood leuke-mia. Journal of environmental science and health. Part C. Environmental Carcinogenesis & Ecotoxicology Reviews. 2015;33(1):36-66.
- Hammer GP, Seidenbusch MC, Schneider K, Regulla DF, Zeeb H, Spix C, et al. A cohort study of childhood cancer incidence after postnatal diagnostic x-Ray exposure. Radiation Research. 2009;171:504-12.
- Mosby TT, Cosgrove M, Sarkardei S, Platt KL, Kaina B. Nutrition in adult and childhood cancer: role of carcinogens and anti-carcinogens. Anticancer research. 2012;32(10):4171-92.
- Robbins E. Radiation risks from imaging studies in children with can-cer. Pediatr Blood Cancer. 2008;51:453-7.
- Wakeford R. On pre- or post-natal diagnostic X-rays as a risk factor for childhood cancer. Radiat Environ Biophys. 2009;48:237-9.
- Horton SJ, Huntly BJ. Recent advances in acute myeloid leukemia stem cell biology. Haematologica. 2012;97(7):966-9.
- Linet MS, Kim KP, Rajaraman P. Children's exposure to diagnostic medical radiation and cancer risk: epidemiologic and dosimetric consid-erations. Pediatric Radiology. 2009;39(Suppl 1):S4-26.
- Schulze-Rath R, Hammer GP, Blettner M. Are pre- or post-natal diag-nostic X-rays a risk factor for childhood cancer? A systematic re-view. Radiat Environ Biophys. 2008;47:301-12.
- Wrixon AD. New International Commission on Radiological Protection (ICRP) recommendations. J Radiol Prot. 2008;28:161-8.
Authors' information:
Usenova Asel Abdumomunovna
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases, International Higher School of Medicine
Conflicts of interest: No conflict
Address for correspondence:
Usenova Asel Abdumomunovna
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases, International Higher School of Medicine
720054, Kyrgyz Republic, Bishkek, str. Intergelpo, 1F
Tel.: (+996) 555 677866
E-mail: usenova@gmail.com
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