Pediatrics
doi: 10.25005/2074-0581-2020-22-4-565-571
ACID-BASIC BALANCE, BLOOD GASES AND ECHOCARDIOGRAPHIC CHANGES IN BRONCHIAL ASTHMA IN CHILDREN

K.I. Ismoilov, M.M. Sharipova

Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To examine the acid-base balance, blood gases and echocardiographic changes in bronchial asthma in children.

Methods: The results of the examination of 60 children suffering from bronchial asthma (BA), aged from 5 to 14 years are presented. The patients were divided into 2 groups depending on their age. The first group consisted of 28 children from 5 to 10 years old, the second – 32 children aged 11 to 14 years. The control group included 20 healthy children, identical to the surveyed groups in terms of gender and age. Echocardiography was performed on a Vivad 3 apparatus (GE, USA), the acid-base balance and blood gases were studied on an ABL 800 Flex apparatus (Radiometer Medical, Denmark).

Results: Studies have shown that children with asthma had significant changes in the ventilation capacity of the lungs in the form of perfusion and diffusion disorders, which undoubtedly influenced the severity of their condition. In children of both groups, there was a significant lack of bases (p<0.001) and a decrease of pH average value in comparison with similar indicators of healthy children. A significant difference in BE and pH values was found between the two groups of patients (p<0.01). The main changes in hemodynamics were reflected in the indicators of TV A and TV E/A. As in children under 10 years of age with BA, and in children over 10 years of age with BA, TV A was higher than in children of the control group (0.48±0.02 versus 0.38±0.02 (p<0.05) and 0.59±0.02 versus 0.49±0.02 (p<0.05) respectively), while the TV E/A ratio was lower in children with BA (1.22±0.03 versus 1.42±0.05 (p<0.05) and 1.31±0.04 versus 1.59±0.06 (p<0.05) respectively).

Conclusion: It was found that third patients in the interictus period of the disease have mild hypoxemia, which, as a rule, is combined with a drop in the alveolar-arterial O2 gradient. The examined patients were characterized by respiratory acidosis. The detected echocardiographic changes confirmed the presence of myocardial dystrophy and the development of «cor pulmonale» in 2 children of the second group with more than 6 years and occurring frequent exacerbations.

Keywords: Bronchial asthma, children, heart, echocardiography, acid-base balance, blood gases.

Download file:

References
  1. Markova TP, Kim MN. Osobennosty patogeneza i vrozhdyonnogo immuniteta pri bronkhial’noy astme [Distinction of pathogenesis and congenial immunity at the time bronchial asthma]. Pediatriya. 2016;95(4):110-5.
  2. Eliseeva TI, Balabolkin II. Sovremennye tekhnologii kontrolya bronkhial’noy astmy u detey [Modern technologies for the control of bronchial asthma in children]. Sovremennye tekhnologii v meditsine. 2015;7(2):168-84.
  3. Ismoilov KI, Sharipova MM. Osobennosti funktsii vneshnego dykhaniya i serdechno-sosudistoy sistemy u detey s bronkhial’noy astmoy [Features of external respiration function and cardiovascular system in children with bronchial asthma]. Vestnik Akademii meditsinskikh nauk Tadzhikistana. 2019;9(1):18-24. Available from: https://doi.org/10.31712/2221-7355-2019- 9-1-18-24
  4. Stepanova IE. Bronkhorasshiryaushchie sredstva dlitel’nogo deystviya pri lechenii stabil’noy khronicheskoy obstruktivnoy bolezni lyogkikh. Analiz novykh dannykh. Terapevticheskiy arkhiv. 2016;78(11):92-4.
  5. Sobchenko SA. Obostrenie nealergicheskoy pozdney astmy, indutsrirovannoe respiratornoy infeksiey [An exacenbation of non-allergic late asthma induced by a respiratory infection]. Pul’monologiya. 2015;2:42-5.
  6. Lyapunova EV, Popova IV, Tokarev AN, Belyakov VA. Prediktory razvitiya bronkhial’noy astmy u detey [The predictors of development of bronchial asthma in children]. Problemy sotsial’noy gigieny, zdravookhraneniya i istorii meditsiny. 2010;6:17-9.
  7. Zhukova OV. Analiz lekarstvennoy nagruzki kak osnova optimizatsii farmakoterapii obostreniy bronkhial’noy astmy u detey [The analysis of medication load as a basis of optimization of pharmaceutical therapy of exacerbation of bronchial asthma in children]. Problemy sotsialnoy gigieny, zdravookhraneniya i istorii meditsiny. 2018;26(3);186-8. Available from: https://doi. org/10.18821/0869-866X-2018-26-3-186-188
  8. Vertkin AL. Komorbidnost’ [Comorbidity]. Klinicheskaya meditsina. 2012;10:4-11.
  9. Barlamov PN. Neyrorespiratornyy sindrom u bol’nykh bronkhial’noy astmoy [Neurorespitory syndrome in patients with bronchial asthma]. Pul‘monologiya. 2013;6:64-8.
  10. Dybunova EL. Rasprostranyonnost’ alergicheskikh zabolevaniy u detey, prozhivayushchikh v razlichnykh ekologo-geograficheskikh usloviyakh [The prevalence of allergic diseases in children living in various environmental and geographical conditions]. Voprosy sovremennoy pediatrii. 2017;6(4):12-6.
  11. Ganiev AG, Khaydarova LR. Osnovnye pokazateli kachestva zhizni podrostkov s bronkhial’noy astmoy [Main indicators of the quality of life of adolescents with bronchial asthma]. Biologiya i integrativnaya meditsina. 2019;4:59-65
  12. Soodaeva SK. Narusheniya okislitel’nogo metabolizma pri zabolevaniyakh respiratornogo trakta i sovremennye podkhody k antioksidantnoy terapii [Disorders of oxidative metabolism in diseases of the respiratory tract and modern approaches to antioxidant therapy]. Pul’monologiya i alergologiya. 2009;1:34-8.
  13. Yartsev SS. Graficheskiy analiz informativnosti OFV pri otsenke bronkhodilyatatsionnogo otveta u bol’nykh bronkhial’noy astmoy [Grafical analysis of informativeness forse expiratory volume when evaluating the bronchodilatation response in patients with bronchial asthma]. Pul’monologiya. 2015;86:353-60.
  14. Fitzpatrick AM, Baena-Cagnani CE, Bacharier LB. Severe asthma in childhood: Recent advances in phenotyping and pathogenesis. Curr Opin Allergy Clin Immunol. 2012;12(2):193-201.
  15. Larkin EK. New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. Am J Respir Crit Care Med. 2015;191(1):45-53.

Authors' information:

Sharipova Mavluda Mirzomuddinovna
Candidate of Medical Sciences, Assistant of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-0946-5712
SPIN: 6703-1473
E-mail: mavluda.sharipova.1988@mail.ru

Ismoilov Komildzhon Isroilovich
Doctor of Medical Sciences, Full Professor, Head of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-2431-1551
SPIN: 6886-8004
Author ID: 847074
E-mail: ismoilov52@inbox.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Sharipova Mavluda Mirzomuddinovna
Candidate of Medical Sciences, Assistant of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (881) 880809

E-mail: mavluda.sharipova.1988@mail.ru

Materials on the topic:
  1. IMPACT OF THE COVID-19 PANDEMIC ON VITAMIN D LEVELS IN CHILDREN OF RYAZAN
  2. EPIDEMIOLOGICAL ASPECTS OF CONTEMPORARY PHYSICAL DEVELOPMENT IN CHILDREN
  3. OXIDANT AND ANTIOXIDANT STATUS IN NEONATES WITH SPECIFIC INTRAUTERINE INFECTIONS
  4. CLINICAL AND ANAMNESTIC PATTERN AND SENSITIZATION TO AEROALLERGENS IN CHILDREN WITH ATOPIC BRONCHIAL ASTHMA
  5. Exercise-related changes of the physiological indicators in children with different forms of spastic cerebral palsy
  6. ADHERENCE TO THERAPY AND ITS IMPACT ON THE CONTROL OF ASTHMA SYMPTOMS IN CHILDREN
  7. FEATURES OF CLINICAL MANIFESTATIONS, CELLULAR AND HUMORAL IMMUNITY OF NEWBORNS WITH INTRAUTERINE MIXED INFECTIONS
  8. CLINICAL AND LABORATORY FEATURES OF ENDOGENOUS INTOXICATION SYNDROME IN CHILDREN UNDER 3 YEARS WITH PNEUMONIA
  9. HUMAN HERPES VIRUS TYPE 6 INFECTION IN CHILDREN AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THE REPUBLIC OF BELARUS
  10. INDICATORS OF SORPTION ABILITY AND PERMEABILITY OF ERYTHROCYTE MEMBRANES IN CHILDREN AND NEWBORNS, LIVING IN THE AREA OF INCREASED RADIATION BACKGROUND

◄ Back to the list