Pediatrics

doi: 10.25005/2074-0581-2020-22-4-565-571
ACID-BASIC BALANCE, BLOOD GASES AND ECHOCARDIOGRAPHIC CHANGES IN BRONCHIAL ASTHMA IN CHILDREN

K.I. Ismoilov, M.M. Sharipova

Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To examine the acid-base balance, blood gases and echocardiographic changes in bronchial asthma in children.

Methods: The results of the examination of 60 children suffering from bronchial asthma (BA), aged from 5 to 14 years are presented. The patients were divided into 2 groups depending on their age. The first group consisted of 28 children from 5 to 10 years old, the second – 32 children aged 11 to 14 years. The control group included 20 healthy children, identical to the surveyed groups in terms of gender and age. Echocardiography was performed on a Vivad 3 apparatus (GE, USA), the acid-base balance and blood gases were studied on an ABL 800 Flex apparatus (Radiometer Medical, Denmark).

Results: Studies have shown that children with asthma had significant changes in the ventilation capacity of the lungs in the form of perfusion and diffusion disorders, which undoubtedly influenced the severity of their condition. In children of both groups, there was a significant lack of bases (p<0.001) and a decrease of pH average value in comparison with similar indicators of healthy children. A significant difference in BE and pH values was found between the two groups of patients (p<0.01). The main changes in hemodynamics were reflected in the indicators of TV A and TV E/A. As in children under 10 years of age with BA, and in children over 10 years of age with BA, TV A was higher than in children of the control group (0.48±0.02 versus 0.38±0.02 (p<0.05) and 0.59±0.02 versus 0.49±0.02 (p<0.05) respectively), while the TV E/A ratio was lower in children with BA (1.22±0.03 versus 1.42±0.05 (p<0.05) and 1.31±0.04 versus 1.59±0.06 (p<0.05) respectively).

Conclusions: It was found that third patients in the interictus period of the disease have mild hypoxemia, which, as a rule, is combined with a drop in the alveolar-arterial O2 gradient. The examined patients were characterized by respiratory acidosis. The detected echocardiographic changes confirmed the presence of myocardial dystrophy and the development of «cor pulmonale» in 2 children of the second group with more than 6 years and occurring frequent exacerbations.

Keywords: Bronchial asthma, children, heart, echocardiography, acid-base balance, blood gases.

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Authors informations:

Sharipova Mavluda Mirzomuddinovna
Candidate of Medical Sciences, Assistant of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-0946-5712
SPIN: 6703-1473
E-mail: mavluda.sharipova.1988@mail.ru

Ismoilov Komildzhon Isroilovich
Doctor of Medical Sciences, Full Professor, Head of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-2431-1551
SPIN: 6886-8004
Author ID: 847074
E-mail: ismoilov52@inbox.ru

Information about the source of support in the form of grants, equipment, and drugs

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflict of interest: No conflict

Address for correspondence:

Sharipova Mavluda Mirzomuddinovna
Candidate of Medical Sciences, Assistant of the Department of Pediatric Diseases № 2, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (881) 880809

E-mail: mavluda.sharipova.1988@mail.ru

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