Pathophysiology
doi: 10.25005/2074-0581-2021-23-2-235-241
PREVALENCE OF MYCOBACTERIUM TUBERCULOSIS AMONG CHILDREN AT THE RESERVOIRS OF INFECTION IN THE REPUBLIC OF TAJIKISTAN
1Department of Phthisiopulmonology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Functional Diagnostics and Clinical Laboratory, Tajik National University, Dushanbe, Republic of Tajikistan
Objective: To study the prevalence of Mycobacterium tuberculosis at the infection reservoirs in the Republic of Tajikistan among children and the impact of BCG vaccination assessed by tuberculin skin test.
Methods: The results of tuberculin skin test in children from Mycobacterium tuberculosis seedbeds in the Republic of Tajikistan were analyzed in the city of Bokhtar (n=176) and the village of Dusti, Khatlon region (n=124). The impact of BCG vaccination in children under 6 years of age was considered in interpretation of the tuberculin skin test results.
Results: The positive result of the tuberculin skin test in children aged 0-6 years was found in 64.7% of cases, 7-14 years – in 47.0% and 15-17 years – in 61.5% respectively. It was shown that rate of high degree of tuberculin sensitivity in children from Mycobacterium tuberculosis reservoirs increased with age. The highest rate of tuberculin sensitivity was observed in 15-17 years old children, and among them in the city – 22.2%, in the village – 27.3%; followed by the age group 7-14 years: in the city – 20%, in the village – 25%. In the age group 0-6 years, this indicator was 2.4% and 3% respectively.
Conclusion: The analysis shows that the situation with tuberculosis in the reservoirs of infection, especially in children aged 7 years and over, is challenging. For the correct interpretation of tuberculin test results in children under 6 years of age, it is important to consider the effect of BCG vaccination. Prevalence of the tuberculosis among the children at the infection reservoirs is high, which requires special attention and measures for comprehensive prevention of tuberculosis in its seedbeds. Insufficient monitoring of contact children residing in the reservoirs of infection is an important factor contributing to the late detection of severe and complicated forms of tuberculosis in children.
Keywords: Tuberculosis, reservoirs of tuberculosis infection, BCG vaccination, tuberculin test, adolescence, infection, morbidity.
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Authors' information:
Bobokhojaev Oktam Ikramovich
Doctor of Medical Sciences, Associate Professor, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University
Scopus ID: 55841885300
ORCID ID: 0000-0002-8619-3426
SPIN: 6745-5078
Author ID: 275977
E-mail: bobokhojaev@mail.ru
Sirodjidinova Umriniso Yusupovna
Doctor of Medical Sciences, Full Professor, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-2981-8362
SPIN: 1802-3224
E-mail: umrinisso@yandex.ru
Saydaliev Sadullo Makhmadalievich
Candidate of Medical Sciences, Head of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-4462-9471
E-mail: saidalievs@mail.ru
Bozorova Rukhshona Sayfuddinovna
Candidate of Medical Sciences, Assistant, Department of Functional Diagnostics and Clinical Laboratory, Tajik National University
ORCID ID: 0000-0002-9931-7723
E-mail: bozorovar@mail.ru
Information about support in the form of grants, equipment, medications
The authors did not receive financial support from companies manufacturing medications and medical equipment
Conflicts of interest: No conflict
Address for correspondence:
Bobokhojaev Oktam Ikramovich
Doctor of Medical Sciences, Associate Professor, Professor of the Department of Phthisiopulmonology, Avicenna Tajik State Medical University
734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139
Tel.: +992 (779) 995433
E-mail: bobokhojaev@mail.ru
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