Pharmacology

doi: 10.25005/2074-0581-2022-24-1-66-84
ANALYSIS OF ANTIBACTERIAL AND FUNGICIDAL ACTIVITY OF ALLIUM OSHANINII AND ALLIUM SUWOROWII DEPENDING ON THE ALTITUDE OF PLANT GROWTH

F.D. Mirzoeva

Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the biological properties of plants of the genus Allium and their correlation with antimicrobial and fungicidal activity depending on the altitude of plant growth.

Methods: Seeds, leaves and bulbs of widespread wild and endemic species of the genus Allium growing in various regions of the Republic of Tajikistan were the objects of the study. The antimicrobial activity of the obtained extracts was studied against standard museum microorganisms (test strains): Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930), Klebsiella pneumoniae (ATCC 4927), Escherichia coli (ATCC 4928). Antifungal activity was studied against Candida species.

Results: Correlation of varying strength was discovered between the content of biocomponents with antimicrobial and fungicidal activity, the altitude of plant growth and place of its collection. The content of total polyphenols and the antioxidant activity of extracts obtained from various parts of the plants varied over a wide range. In some cases, there were direct correlations of varying strength between the content of polyphenols, antioxidative, antimicrobial and fungicidal properties of the plants.

Conclusion: This study showed the insignificant correlations between the content of biocomponents and antimicrobial, and fungicidal properties of the studied types of onions, which did not depend on the growing zone.

Keywords: Onion, plant, growth inhibition, extract, reference bacterial strains.

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References
  1. Sagar NA, Pareek S, Sharma S, Yahia EM, Lobo MG. Fruit and vegetable waste: Bioactive compounds, their extraction, and possible utilization. Comp. Rev Food Sci Food Saf. 2018;17(1):512-31.
  2. Santas J, Almajano MP, Carbo R. Antimicrobial and antioxidant activity of crude onion (Allium cepa L.) extracts. Int J Food Sci Technol. 2010;45(1):403-9.
  3. Ivanova I, Bukharov AF, Baleev DN, Bukharova AR, Kashleva AI, Seredin TM, i dr. Biokhimicheskiy sostav list’ev vidov Allium L. v usloviyakh Moskovskoy oblasti [Biochemical composition of the leaves of Allium L. species in the Moscow region]. Dostizheniya nauki i tekhniki APK. 2019;33(5):47-50.
  4. Liu Q, Meng X, Li Y, Zhao CN, Tang GY, Li HB. Antibacterial and antifungal activities of spices. Int J Mol Sci. 2017;18:3-61.
  5. Ahmad KhSh, Jameel M, Kanwal S, Shahid S. Medicinal importance of Allium species: A current review. International Journal of Pharmaceutical Science and Research. 2017;2(3):29-39.
  6. Mirzoeva FD, Averbakh MM, Sterzhanova NV, Satorov SS, Nikonenko BV. Vliyanie ekstrakta luka Oshanina (gornyy Tadzhikistan) na techenie tuberkulyoznoy infektsii v eksperimente u inbrednykh myshey [Influence of onion extract of oshaninii (mountainous Tajikistan) on the course of tuberculosis infecton in an experiment in inbred mice]. Vestnik TSNIIT. 2021;1:21-7.
  7. Othman L, Sleiman A, Raula M, Abdel M. Antimicrobial activity of polyphenols and alkaloids in Middle Eastern plants. Front Microbiol. 2019;10:911.
  8. Satorov S, Mirzoeva F, Kurbonbekova Sh, Satorov Sh, Vakhidova M, Dushenkov V. Antibacterial, antifungal, antioxidant activity and polyphenol content of aerial parts and bulb of Allium schugnanicum. Vestnik Avitsenny [Avicenna Bulletin]. 2020;22(1):98-105. Available from: https://doi.org/10.25005/2074- 0581-2020-22-1-98-105
  9. Mojzer BE, Hrncic MK, Skerget M, Knez Z, Bren U. Polyphenols: Extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules. 2016;21(7):901.
  10. Wu D, Kong Y, Cong H, Chen J, Hu L, Jiang H, Shen J. D-Alanine: D-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int J Antimicrob Agents. 2008;32(5):421-6
  11. Satorov S, Mirzoeva FD. Soderzhanie obshchich polifenolov i antioksidantnaya aktivnost' rasteniy roda Allium i ikh korrelyatsiya s antibakterial’noy i protivogribkovoy aktivnost’yu [The content of significant polyphenols and antioxidant activity of plants of the genus Allium and their correlation with antibacterial and antifungal activity]. Zdravookhranenie Tadzhikistana. 2021;2:85-97.
  12. Sah P, Al-Tammi B, Al-Nassri N, Al-Mamari R. Effect of temperature on antibiotic properties of garlic (Allium sativum L.) and ginger (Zingiber officinale Rosc.). African Journal of Biotechnology. 2012;11:16192-5.
  13. Demidenko GA. Rol’ ekologicheskikh faktorov pri vyrashchivanii pera luka repchatogo v zakrytykh agrosistemakh Krasnoyarskoy aglomeratsii [The role of environmental factors in the cultivation of onion feathers in closed agrosystems of the Krasnoyarsk agglomeration]. Vestnik KrasGAU. 2016;7(10):1-11.
  14. Fomina TI, Kukushkina TA. Soderzhanie biologicheski aktivnykh veshchestv v nadzemnoy chaste nekotorykh vidov luka (Allium L.) [The content of biologically active substances in the aerial part of some types of onions (Allium L.)]. Khimiya rastitel'nogo syr'ya. 2019;3:177-84.
  15. Sagar NA, Pareek S. Antimicrobial assessment of polyphenolic extracts from onion (Allium cepa L.) skin of fifteen cultivars by sonication-assisted extraction method. Heliyon. 2020;6(11):3-4.
  16. Satorov S, Mirzoeva FD. Sravnitelnaya otsenka fungitsidnoy aktivnosti shiroko rasprostranyonnykh dikorastushchikh i endemichnykh vidov roda Allium, proizrastayushchikh v Tadzhikstane [Comparative evaluation of the fungicidal activity of widespread wild and endemic species of the genus Allium growing in Tajikistan]. Zdravookhraneniye Tadzhikistana. 2021;3:55-61.
  17. de Falco B, Bonanomi G, Lanzotti V. Dithiosulfinates and sulfoxides with antifungal activity from bulbs of Allium sativum L. var. Voghiera. Natural Product Communication. 2018;13(9):1164-6.
  18. Khodadi S, Nejatsattori T, Naqinezhad A, Aliebrahimzadeh M. Diversity in antioxidant properties and mineral contents of Allium paradoxum in the Hyrcanian forests, Northern Iran. Biodiversitas. 2015;16(2):281-7.
  19. Thabti I, Elfalleh W, Tlili N, Ziadi M, Campos MG, Ferchichi A. Phenols, flavonoids, and antioxidant and antibacterial activity of leaves and stem Bark of Morus species. International Journal of Food Properties. 2014;17(4):842-85.
  20. Satorov S, Mirzoeva F, Satorov S, Vakhidova M, Dushenkov V. Sravnitel’naya kharakteristika antibakterial'noy aktivnosti nekotorykh rasteniy, proizrastayushchikh v tsentral'noy chaste Respubliki Tadzhikistan [Comparative characteristics of antibacterial activity of plants growing in the central part of the Republic of Tajikistan]. Vestnik Avitsenny [Avicenna Bulletin]. 2019;21(4):643- 54. Available from: https://doi.org/10.25005/2074-0581-2019-21-4-643-654
  21. Skubel SA, Dushenkov V, Graf BL, Niu Q, Poulev A, Kalariya HM, et al. Rapid, field deployable method for collecting and preserving plant metabolome for biochemical and functional characterization. PLoS One. 2018;13(9):1-19.
  22. Khalil N, El-Jalel L, Yousif M, Gonaid M. Altitude impact on the chemical profile and biological activities of Satureja thymbra L. essential oil. BMC Complement Med Ther. 2020;20(1):186.
  23. Munné-Bosch S, Cotado A, Morales M, Fleta-Soriano E, Villellas J, Garcia MB. Adaptation of the long-lived monocarpic perennial Saxifraga longifolia to high altitude. Plant Physiol. 2016;172(2):765-75.
  24. Kara M, Soylu S, Turkmen M, Kaya A. Determination and antifungal activities of laurel and fennel essential oils against fungal disease agents of cypress seedlings. Journal of Tekirdag Agricultural Faculty. 2020;17(2):264-75.

Authors informations:

Mirzoeva Fazila Davlatalievna
Acting Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-0187-0334
E-mail: fazila.mirzoeva88@mail.ru

Information about the source of support in the form of grants, equipment, and drugs

The author did not receive financial support from manufacturers of medicines and medical equipment

Conflict of interest: No conflict

Address for correspondence:

Mirzoeva Fazila Davlatalievna Acting Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University

Acting Head of the Department of Microbiology, Immunology and Virology, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (919) 192191

E-mail: fazila.mirzoeva88@mail.ru

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