Plastic Surgery
doi: 10.25005/2074-0581-2025-27-3-723-735
CURRENT METHODS OF SKIN RECONSTRUCTION SURGERY
1Department of Surgery No. 1, Kuban State Medical University, Krasnodar, Russian Federation
2Scientific Research Institute – Regional Clinical Hospital No. 1 named after Professor Ochapovsky, Krasnodar, Russian Federation
3Levshin Institute of Cluster Oncology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
4Department of Oncology, Radiotherapy and Plastic Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
5Laboratory of Experimental and Cellular Medicine, Moscow Institute of Physics and Technology (National Research University), Moscow, Russian Federation
6Sochi City Hospital No. 4, Sochi, Russian Federation
7Sochi City Hospital No. 3, Sochi, Russian Federation
The article reviews the current literature on modern approaches to treating skin defects. The research was based on publications from the last decade, specifically from 2005 to 2024, sourced from eLibrary.ru, cyberleninka.ru, PubMed, and Scopus. The search utilized keywords such as "wounds", "skin defects", "healing", "skin grafts", and "prolonged tissue expansion”. A total of 42 publications that met the search criteria were selected for review, including 21 studies from the past five years. The analysis focused on publications related to the surgical treatment of extensive soft tissue defects using various wound closure techniques, including skin grafting. Articles that addressed the topic but did not describe the surgical aspects of treatment were excluded.
The article covers wound management, including skin edge excisional debridement, followed by closure using various plastic surgery techniques. It presents the advantages and disadvantages of using skin flaps, skin grafts, and local flaps for closing extensive skin defects. Recently, the prolonged tissue expansion (PTE) technique has gained popularity, and the article highlights its potential as a promising method for treating extensive skin defects. Additionally, it covers methods for stimulating reparative processes. The combination of reconstructive plastic closure techniques appears to be promising, as it leads to better functional and aesthetic outcomes.
Keywords: Wounds, skin defects, healing, skin grafts, prolonged tissue expansion.
References
- Gushiken LFS, Beserra FP, Bastos JK, Jackson CJ, Pellizzon CH. Cutaneous wound healing: An update from physiopathology to current therapies. Life (Basel). 2021;11(7):665. https://doi.org/10.3390/life11070665
- Almadani YH, Vorstenbosch J, Davison PG, Murphy AM. Wound healing: A comprehensive review. Semin Plast Surg. 2021;35(3):141-4. https://doi. org/10.1055/s-0041-1731791
- Childs DR, Murthy AS. Overview of wound healing and management. Surg Clin North Am. 2017;97(1):189-207. https://doi.org/10.1016/j.suc.2016.08.013
- Gonzalez AC, Costa TF, Andrade ZA, Medrado AR. Wound healing – a literature review. An Bras Dermatol. 2016;91(5):614-20. https://doi.org/10.1590/ abd1806-4841.20164741
- Martel II, Grebenyuk LA. Zameshchenie defekta myagkikh tkaney opornoy poverkhnosti stopy po metodike Ilizarova pod kontrolem mekhano- biologicheskogo sostoyaniya kozhi [Soft tissue defects of the foot supporting surface repaired with the Ilizarov method under control of mechanical and biological condition of the skin]. Politravma. 2018;1:39-46.
- Braun TL, Hamilton KL, Monson LA, Buchanan EP, Hollier LH. Tissue expansion in children. Semin Plast Surg. 2016;30(4):155-61. https://doi. org/10.1055/s-0036-1593479
- Zhang Q, Xu L, Liu Y, Tang X, Wang J, Deng Y, et al. Application of skin-stretching device for closing scalp defect. J Craniofac Surg. 2023;34(1):374-80. https://doi. org/ 10.1097/SCS.0000000000008856
- Yuan B, Liang HD, Tong ZH, Song WJ, Ju SL. Application effect of sustainable skin- stretching device in scalp and soft tissue defect. Zhonghua Shao Shang Za Zhi. 2020;36(12):1204-7. https://doi.org/10.3760/cma.j.cn501120-20200215-00061
- Han Y, Zhao J, Tao R, Guo L, Yang H, Zeng W, et al. Repair of craniomaxillofacial traumatic soft tissue defects with tissue expansion in the early stage. J Craniofac Surg. 2017;28(6):1477-80. https://doi.org/10.1097/SCS.0000000000003852
- Gus E, Zhu J, Brooks SG. Postburn breast reconstruction: A scoping review. Scars Burn Heal. 2023;9:20595131231202100. https://doi. org/10.1177/20595131231202100
- Byun SH, Kim SY, Lee H, Lim HK, Kim JW, Lee UL, et al. Soft tissue expander for vertically atrophied alveolar ridges: Prospective, multicenter, randomized controlled trial. Clin Oral Implants Res. 2020;31(7):585-594. https://doi. org/10.1111/clr.13595
- Ruiz YG, Gutiérrez JCL. Multiple tissue expansion for giant congenital melanocytic nevus. Ann Plast Surg. 2017;79(6):37-40. https://doi.org/10.1097/ SAP.0000000000001215
- Hussain SH, Limthongkul B, Humphreys TR. The biomechanical properties of the skin. Dermatol Surg. 2013;39(2):193-203. https://doi.org/10.1111/dsu.12095
- Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, et al. Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature. 2020;584(7820):268-73. https://doi.org/10.1038/s41586-020-2555-7.
- Bogdanov SB. Vidy kozhnykh autoplastik. Atlas [Types of skin autoplasty. Atlas]. Krasnodar, RF: OOO «Klub Pechati»; 2018: 200 p.
- Azamatovich ShZh, Ulashovich TIU, Abduganievich MA, Kholdorovich SS. Osobennosti khirurgicheskoy taktiki pri operatsiyakh sindaktilii u detey [Features of surgical tactics in syndactyly operations in children]. Research Journal of Trauma and Disability Studies. 2024;3(5):122-6.
- Fedyanin SD, Kosinets VA. Sovershenstvovanie kompleksnogo lecheniya khirurgicheskikh infektsiy kozhi i myagkikh tkaney [Improving the comprehensive treatment of surgical infections of the skin and soft tissues]. Kyirurgiya. Vostochnaya Evropa. 2021;10(3):371-8.
- Polyakov AV, Bogdanov SB, Afanasov IM, Karakulev AV, Bogdanova YuA, Zinoviev EV, i dr. Ispol'zovanie ranevykh pokrytiy na osnove khitozana "khitopran" v lechenii bol'nykh s ozhogovoy travmoy [The use of chitosan-based wound coatings "chitopran" in the treatment of patients with burn injury]. Innovatsionnaya meditsina Kubani. 2019;15(3):25-31.
- Aladyina VA, Bogdanov SB. 85 let plastiki polnosloynym loskutom po Krasovitovu [85 years of plastic surgery with a full-layer flap according to Krasovitov]. Neotlozhnaya khirurgiya im. I.I. Dzhanelidze. 2021;1:6.
- Bogdanov SB, Aladyina VA, Marchenko DN, Polyakov AV, Melkonyan KI, Gilevich IV, i dr. Khirurgicheskie aspekty prizhivleniya polnosloynogo kozhnogo autotransplantata na granuliruyushchuyu ranu [Surgical aspects of engraftment of a full-layer skin autograft on a granulating wound]. Innovatsionnaya meditsina Kubani. 2020;18(2):41-5. https://doi.org/10.35401/2500-0268-2020-18-2-41-45
- Mitish VA, Medinskiy PV, Bagaev VG. Khirurgicheskoe lechenie obshirnoy skal'pirovannoy rany temenno-zatylochnoy oblasti [Surgical treatment of an extensive scalp wound of the parietal-occipital region]. Rany i ranevye infektsii. Zhurnal imeni professora B.M. Kostyuchyonka. 2021;8(1):42-9. https://doi. org/10.25199/2408-9613-2021-8-1-42-49
- Boboev RS, Mukhametzyanova AT, Pekanova EV, Zubareva AS. Primenenie metoda plastiki mestnymi tkanyami pri udalenii novoobrazovaniy chelyustno- licevoy oblasti [Application of the method of plastic surgery with local tissues in the removal of neoplasms of the maxillofacial region]. Universitetskaya meditsina Urala. 2021;25(7):29-32.
- Aleksandrov AV, Goncharuk PV, Idris LY, Rybchenok VV, Smirnov AA, Khagurov RA. Khirurgicheskaya rekonstruktsiya myagkikh tkaney distal'nykh falang pal'tsev kisti u detey. Obzor literatury[Soft tissue surgical reconstruction of distal phalanges in children. Review]. Rossiyskiy vestnik detskoy khirurgii, anesteziologii i reanimatologii. 2024;14(1):107-20. https://doi.org/10.17816/psaic1766
- Alawi SA, Rudari M, Dragu A. Evidence-based research in plastic and aesthetic surgery: cross-sectional analysis of research papers between 2019 and 2021. Handchir Mikrochir Plast Chir. 2023;55(2):159-66. https://doi. org/10.1055/a-1992-5705
- Bakhiet MY, Alshareef AM, Abuelnour AEK, Asiri MN, Alzahrani RAJ, Alghamdi SMS, et al. Publications in plastic surgery and reconstruction: A review from a developing country, Sudan. Plast Reconstr Surg Glob Open. 2024;12(5):e5761. https://doi.org/10.1097/GOX.0000000000005761
- Karimi H, Latifi NA, Momeni M, Sedigh-Maroufi S, Karimi AM, Akhoondinasab MR. Tissue expanders; review of indications, results and outcome during 15 years’ experience. Burns. 2019;45(4):990-1004. https://doi.org/10.1016/j. burns.2018.11.017
- Gilevich IV, Fedorenko TV, Kolomiytseva EA, Bogdanov SB, Semenchenko AA, Ivashchuk YuV. Dostizheniya kletochnoy terapii v kombustiologii [Achievements of cell therapy in combustiology]. Innovatsionnaya meditsina Kubani. 2017;6(2):6-14.
- Bogdanov SB, Gilevich IV, Fedorenko TV, Kolomiytseva EA, Polyakov AV. Vozmozhnosti primeneniya kletochnoy terapii v kozhno-plasticheskikh operatsiyakh [The possibilities of using cell therapy in skin plastic surgery]. Innovatsionnaya meditsina Kubani. 2018;11(3):16-21.
- Guimarães CF, Gasperini L, Marques AP, Reis RL. The stiffness of living tissues and its implications for tissue engineering. Nature Reviews Materials. 2020;5:351-70. https://doi.org/10.1038/s41578-019-0169-1
- Tong X, Lu J, Zhang W, Wang S, Huang R, Zhang X, et al. Efficacy and safety of external tissue expansion technique in the treatment of soft tissue defects: A systematic review and meta-analysis of outcomes and complication rates. Burns & Trauma. 2022; 10:tkac045. https://doi.org/10.1093/burnst/tkac045
- Guo Y, Song Y, Xiong S, Wang T, Liu W, Yu Z, et al. Mechanical stretch induced skin regeneration: Molecular and cellular mechanism in skin soft tissue expansion. Int J Mol Sci. 2022;23(17):9622. https://doi.org/10.3390/ijms23179622
- Yu Z, Liu S, Cui J, Song Y, Wang T, Song B, et al. Early histological and ultrastructural changes in expanded murine scalp. Ultrastruct Pathol. 2020;44(1):141-52. https://doi.org/10.1080/01913123.2020.1720876
- Liu S, Ding J, Zhang Y, Cheng X, Dong C, Song Y, et al. Establishment of a novel mouse model for soft tissue expansion. J Surg Res. 2020;253:238-44. https://doi. org/10.1016/j.jss.2020.03.005
- Liu H, Yu Z, Wang J, Zhang X, Lei L, Zhang Y, et al. Effects of botulinum toxin a on the blood flow in expanded rat skin. J Invest Surg. 2022;35(5):1036-43. https:// doi.org/10.1080/08941939.2021.1995539
- Tiryaki T, Cohen SR, Turkay SC, Kocak P, Sterodimas A, Schlaudraff KU, et al. Hybrid stromal vascular fraction (Hybrid-SVF): A new paradigm in mechanical regenerative cell processing. Plast Reconstr Surg Glob Open. 2022;10(12):e4702. https://doi.org/10.1097/GOX.0000000000004702
- Jinming W, Caiyue L, Baojin W, Antang L, Yingfan Z, Hui W, et al. Effects of plateletrich plasma on tissue expansion in rabbits. Aesthetic Plast Surg. 2017;41(2):454- 60. https://doi.org/10.1007/s00266-017-0797-z
- Malikov MKh, Artykov KP, Karimzade GD, Dzhononov DD, Makhmadkulova NA, Khasanov MA. Ustranenie posttravmaticheskikh defektov pokrovnykh tkaney verkhnikh konechnostey [Elimination of post-traumatic defects of the integumentary tissues of the upper extremities]. Plasticheskaya khirurgiya i esteticheskaya meditsina. 2020;1:54-62.
- Pyatakov SN, Baryshev AG, Mukhanov ML, Fedyushkin VV, Arkhipov OI, Porkhanov VA, i dr. Sluchay uspeshnogo primeneniya novogo ustroystva dlya dozirovannogo rastyazheniya myagkikh tkaney pri lechenii postradavshego s obshirnym posttravmaticheskim ranevym defektom goleni [A case of successful application of a new device for metered stretching of soft tissues in the treatment of a victim with extensive post-traumatic wound defect of the lower leg]. Politravma. 2024;3:84-9.
- Pavlenko IV, Gostev VN, Andryukhin KV. Sovremennyy vzglyad na protsessy mekhanotransduktsii v zdorovoy i povrezhdyonnoy kozhe: obzor literatury [Modern view on mechanotransduction processes in healthy and damaged skin: Literature review]. Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. I.I. Mechnikova. 2022;14(1):17-30. https://doi.org/10.17816/ mechnikov104610
- Pyatakov SN, Bogdanov SB, Saprygin PB, Afonichev KA, Baindurashvili AG, Stepanova YuV, i dr. Dozirovannoe rastyazhenie myagkikh tkaney. Rukovodstvo dlya vrachey [Dosed stretching of soft tissues: A guide for doctors]. Moscow, RF: OOO «KLUB PECHATI»; 2022: 229 p.
- Fedyushkin VV, Baryshev AG, Pyatakov SN, Gumenyuk SE, Alukhanyan OA, Bensman VM. Vakuumnaya terapiya v kompleksnom lechenii gnoyno- nekroticheskikh zabolevaniy myagkikh tkaney: klinicheskie sluchai [Vacuum therapy in the complex treatment of purulent-necrotic diseases of soft tissues: Clinical cases]. Kubanskiy nauchnyy meditsinskiy vestnik. 2023;30(2):102-15. https://doi.org/10.25207/1608-6228-2023-30-2-102-115
- Topaz M, Ashkenazi I, Barzel O, Biswas S, Atar D, Shadmi N. Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: A retrospective study. Burns & Trauma. 2021;9:tkab007. https://doi.org/ 10.1093/burnst/tkab007
Authors' information:
Pyatakov Stanislav Nikolaevich,
Doctor of Medical Sciences, Associate Professor, Associate Professor of the Department of Surgery No. 1, Kuban State Medical University
Scopus ID: 57194482436
ORCID ID: 0000-0002-3096-0008
SPIN: 1386-0007
Author ID: 691148
E-mail: spyatakov@inbox.ru
Porkhanov Vladimir Alekseevich,
Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Full Professor, Chief Physician, Scientific Research Institute – Regional Clinical Hospital No. 1 named after Professor Ochapovsky
Researcher ID: O-9470-2017
Scopus ID: 6602279459
ORCID ID: 0000-0003-0572-1395
SPIN: 2446-5933
Author ID: 682896
E-mail: kkb1@mail.ru
Reshetov Igor Vladimirovich,
Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Full Professor, Director of the Levshin Institute of Cluster Oncology; Head of the Department of Oncology, Radiotherapy and Plastic Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University
Researcher ID: J-7005-2014
Scopus ID: 6701353127
ORCID ID: 0000-0002-0909-6278
SPIN: 3845-6604
Author ID: 103745
E-mail: reshetoviv@mail.ru
Mukhanov Mikhail Lvovich,
Candidate of Medical Sciences, Associate Professor, Associate Professor of the Department of Surgery No. 1, Kuban State Medical University
Scopus ID: 57194408950
ORCID ID: 0000-0002-9061-6014
SPIN: 3684-9725
Author ID: 818395
E-mail: pputinn@yandex.ru
Berezhnoy Andrey Konstantinovich,
Engineer, Laboratory of Experimental and Cellular Medicine, Moscow Institute of Physics and Technology (National Research University)
Scopus ID: 57789962500
ORCID ID: 0000-0001-8484-6510
SPIN: 7141-0530
Author ID: 1202627
E-mail: berezhnoi.ak@phystech.edu
Sergeeva Tatyana Olegovna,
Engineer, Laboratory of Experimental and Cellular Medicine, Moscow Institute of Physics and Technology (National Research University)
Scopus ID: 57789962500
ORCID ID: 0009-0004-2753-8270
E-mail: sergeeva2969@yandex.ru
Pyatakova Svetlana Nikolaevna,
Deputy Chief Physician for Organizational and Methodological Work, Surgeon, Sochi City Hospital No. 4
ORCID ID: 0009-0000-7808-5233
E-mail: s_pyatakova@inbox.ru
Chayka Aleksandr Dmitrievich,
Surgeon, Department of Purulent Surgery, Sochi City Hospital No. 4
ORCID ID: 0000-0006-5303-269X
E-mail: chaika.work@mail.ru
Motikov Artyom Borisovich,
Head of the Surgical Department No. 2, Sochi City Hospital No. 3
ORCID ID: 0009-0005-2702-7793
E-mail: motikoff@mail.ru
Information about support in the form of grants, equipment, medications
This article presents the findings of a study conducted as part of a project that won the "Priority 2030" competition at Kuban State Medical University, Russia. The authors did not receive financial support from manufacturers of medicines and medical equipment
Conflicts of interest: No conflict
Address for correspondence:
Pyatakov Stanislav Nikolaevich
Doctor of Medical Sciences, Associate Professor, Associate Professor of the Department of Surgery No. 1, Kuban State Medical University
350063, Russian Federation, Krasnodar, Mitrofan Sedin str., 4 (Central microdistrict)
Tel.: +7 (918) 4755575
E-mail: spyatakov@inbox.ru
This work is licensed under a Creative Commons Attribution 4.0 International License.
Materials on the topic:
- REPAIR OR HEAD AND NECK POSTTRAUMATIC DEFECTS WITH THE LATISSIMUS DORSI MYOCUTANEOUS FLAP: CASE REPORT
- ONE-STAGE RECONSTRUCTION OF A FULL-THICKNESS DEFECT OF THE UPPER THIRD OF THE AURICLE: A CASE REPORT
- USE OF ARTIFICIAL INTELLIGENCE TECHNOLOGIES IN THE SELECTION OF IMPLANTS FOR AUGMENTATION MAMMOPLASTY
- ONE-STAGE CORRECTION OF CHRONIC ULNAR NERVE INJURIES
- COMPREHENSIVE APPROACH TO SURGICAL TREATMENT OF NEUROTROPHIC FOOT ULCER BY LOCAL PLASTIC METHOD: CASE REPORT
- OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN SEVERE UPPER LIMB INJURIES
- REPAIR OF SEVERE POST-BURN CICATRICIAL CONTRACTURES AND DEFORMATIONS OF THE LOWER LIMB
- ANALYSIS OF COMPLICATIONS AFTER AUTOGRAFT TRANSPLANTATION IN SEVERE UPPER LIMB INJURY
- A MODEL FOR ASSESSING THE RISK OF A DELAYED WOUND HEALING IN OBESE PATIENTS
- MAMMOPLASTY: FROM RECONSTRUCTIVE TO AESTHETIC SURGERY