ORIGINAL RESEARCH
Neurology
doi: 10.25005/2074-0581-2026-28-2-356-363
DYNAMICS OF HEART RATE VARIABILITY AND HIGHER NERVOUS ACTIVITY IN STUDENTS FOLLOWING SPUTNIK LIGHT VECTOR VACCINATION

A.YU. ZOLOTUKHINA, I.V. KOZACHUK, E. ACOSTA, A.K. STEPANYAN, M.A. ZOLOTUKHINA, E.M. ZIMAEVA

Derzhavin Tambov State University, Medical Institute, Tambov, Russian Federation

Objective: This study aimed to investigate the impact of the Sputnik Light vaccine on psychophysiological functions and heart rate variability (HRV) in university students.

Methods: The study evaluated simple and complex visual-motor reaction speeds, time perception, mental productivity, and work capacity in first-year students (aged 18-19). Autonomic nervous system responses were assessed using HRV analysis. The study group included 30 vaccinated students, while the control group consisted of 12 unvaccinated students. Assessments were conducted at three time points: baseline (pre-vaccination), 3 days post- vaccination, and 2 weeks post-vaccination.

Results: Three days after vaccination, a statistically significant slowing of simple visual-motor reactions was observed (p<0.01). However, the accuracy of time perception improved by 6.3% (p<0.05), and the number of correct answers in performance testing increased (p<0.05). Parasympathetic activity also increased: RMSSD rose from 45.0 [30.0; 65.0] to 55.0 [40.0; 80.0] ms (p<0.05), while the stress index decreased from 110.0 [54.0; 140.3] to 67.3 [40.0; 85.0] c.u. (p<0.01). After two weeks, all psychophysiological parameters returned to baseline levels. No significant changes were observed in the control group.

Conclusion: Vaccination with Sputnik Light did not produce adverse effects on higher nervous activity or autonomic functions, resulting only in transient physiological shifts.

Keywords: Vaccination, higher nervous activity, heart rate variability, autonomic regulation, post-vaccination reaction.

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Authors' information:

Zolotukhina Alla Yurievna,
Candidate of Biological Sciences, Associate Professor, Associate Professor of Department of Medical Biology, Derzhavin Tambov State University, Medical Institute
ORCID ID: 0000-0003-0051-9606
SPIN: 8724-5921
Author ID: 160757
E-mail: allazol@mail.ru

Kozachuk Irina Valerievna,
Candidate of Biological Sciences, Associate Professor, Associate Professor of Department of Medical Biology, Derzhavin Tambov State University, Medical Institute
ORCID ID: 0000-0002-6406-2898
SPIN: 5535-3983
Author ID: 497196
E-mail: ivk33tmb@mail.ru

Acosta Ekaterina,
6ᵗʰ year Graduate Student of the "General Medicine" program, Derzhavin Tambov State University, Medical Institute
ORCID ID: 0009-0006-1688-6709
E-mail: katherinakosta@gmail.com

Stepanyan Anna Karoevna,
4ᵗʰ year Graduate Student of the "Pediatrics" program, Derzhavin Tambov State University, Medical Institute ORCID ID: 0009-0000-4811-3010 E-mail: annstepanyan02@yandex.ru

Zolotukhina Mariya Alekseevna,
6ᵗʰ year Graduate Student of the "General Medicine" program, Derzhavin Tambov State University, Medical Institute
ORCID ID: 0009-0000-5847-1874
E-mail: mariya.zolotukhina.96@mail.ru

Zimaeva Evgeniya Mikhaylovna,
4ᵗʰ year Graduate Student of the "Dentistry" program, Derzhavin Tambov State University, Medical Institute
ORCID ID: 0009-0001-1237-2034
E-mail: Ezimaeva11@yandex.ru

Information about support in the form of grants, equipment, medications

he article was prepared with the financial September 2, 2024). The authors did not receive financial support from manufacturers of medicines and medical equipment support of a grant from Derzhavin Tambov State University to support research teams (order No. 490/1 dated

Conflicts of interest: No conflict

Address for correspondence:

Zolotukhina Alla Yurievna
Candidate of Biological Sciences, Associate Professor, Associate Professor of Department of Medical Biology, Derzhavin Tambov State University, Medical Institute

392000, Russian Federation, Tambov, Sovetskaya str., 93

Tel.: +7 (961) 6288998

E-mail: allazol@mail.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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