Pathology
doi: 10.25005/2074-0581-2026-28-3-685-695
THE ROLE OF SERUM IFN-γ LEVEL AS A MARKER OF ISCHEMIC STROKE, ITS SEVERITY, AND SHORT-TERM FUNCTIONAL OUTCOME

R.S. GORBARENKO, E.V. MARKELOVA, V.P. ROZUMEYKO, YU.I. MOISEEVA

Pacific State Medical University, Vladivostok, Russian Federation

Objective: To evaluate IFN-γ as a marker of acute ischemic stroke (AIS), as well as its association with stroke severity and short-term functional outcome.

Methods: Changes in serum IFN-γ levels were analyzed in 30 patients with AIS and compared with those in healthy individuals. IFN-γ levels were measured by enzyme-linked immunosorbent assay (ELISA) using reagents from R&D Diagnostic Inc. (USA).

Results: The study demonstrated a statistically significant increase in IFN-γ levels in patients with AIS. Moreover, during the first 10-12 days of hospitalization, serum IFN-γ levels in the AIS group remained significantly higher than those in healthy participants. Serum cytokine levels were also higher in women with AIS than in men. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), which stratified patients into mild/moderate stroke (NIHSS≤8) and moderate/severe stroke (NIHSS>8) groups. IFN-γ did not distinguish stroke severity. However, in patients with moderate/severe stroke, cytokine levels decreased over time. Short-term functional outcome in AIS was assessed using the modified Rankin Scale (mRS), according to which patients were divided into a good-outcome subgroup (mRS 0-2; mRS1) and a poor-outcome subgroup (mRS≥3; mRS2). Based on the obtained data, IFN-γ did not demonstrate prognostic value for short-term functional outcome in AIS.

Conclusion: The study showed that IFN-γ may serve as an additional marker of AIS; however, it cannot be used as an indicator of stroke severity or as a predictor of short-term functional outcome in patients with AIS.

Keywords: Ischemic stroke, stroke severity, stroke outcome, IFN-γ.

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Authors' information:

Gorbarenko Rodion Sergeevich,
Postgraduate Student, Department of Normal and Pathological Physiology, Pacific State Medical University
ORCID ID: 0000-0002-0930-9392
E-mail: rodiongor@mail.ru

Markelova Elena Vladimirovna,
Doctor of Medical Sciences, Full Professor, Head of the Department of Normal and Pathological Physiology, Pacific State Medical University
ORCID ID: 0000-0001-5846-851X
E-mail: markev2010@mail.ru

Rozumeyko Vladimir Petrovich,
Assistant Professor of the Department of Additional Professional Education, Pacific State Medical University
ORCID ID: 0009-0003-7396-2139
E-mail: rozumeiko.vp@mail.ru

Moiseeva Yulia Igorevna,
Undergraduate Student, Pacific State Medical University
ORCID ID: 0009-0007-7883-1479
E-mail: yu.moiseeva@m.tgmu.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Gorbarenko Rodion Sergeevich
Postgraduate Student, Department of Normal and Pathological Physiology, Pacific State Medical University

690013, Russian Federation, Vladivostok, Adm. Kuznetsova str., 78-24

Tel.: +7 (904) 6272828

E-mail: rodiongor@mail.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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