Pediatrics
doi: 10.25005/2074-0581-2017-19-2-219-225
SOME CLINICAL AND IMMUNOLOGICAL ASPECTS OF FREQUENT SICK CHILDREN WITH HYPOTROPHY

G.S. Mamadjanova1, Z.K. Umarova2, M.D. Yodgorova2, M.P. Nosirova2

1Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Tajikistan
2Department of Family Medicine № 2, Avicenna Tajik State Medical University, Dushanbe, Tajikistan

Objective: To study some clinical and immunological aspects of frequent sick children (FSC) with hypotrophy

Methods: 60 FSC with hypotrophy were observed. All children were divided according to the degree and severity of the disease: light – 20, average – 20, heavy – 20. The control group included 20 children. The age composition ranged from 2 months to 2 years. Methods of examination included: clinical observation, laboratory and immunological studies: quantification of leukocytes and lymphocytes. The number of lymphocytes and their subpopulations was determined using monoclonal antibodies to the differential antigens CD3, CD4, CD8, CD20, CD95, CD16, CD32.

Results: In FSC with hypotrophy of light severity showed T-cells, and their subpopulation and Ig A, Ig M, and Ig G values tended to decrease in comparison with the control group. In most cases, they had uncomplicated respiratory infections, and there were no statistically reliable deviations. In FSC with hypotrophy of average severity, there was a noticeable and reliable decrease in both cellular and humoral immunity. The indices in patients with heavy severity of disease in comparison with those, in patient’s groups I and II differed even with a higher significant difference. The effectiveness of immunomodulatory therapy has been noted.

Conclusion: Immunomodulatory therapy in combination with basic therapy led to a significant increase in the indices of cellular and humoral immunity in dynamics. The evidence of this was a significant decrease in intercurrent diseases in FSC with hypotrophy.

Keywords: Frequent sick children, hypotrophy, cellular and humoral immunity, complex treatment.

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Authors' information:

Mamadzhanova Gulnora Sidikzhanovna, Candidate of Medical Sciences, Associate Professor of the Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

Umarova Zarifa Kosimovna, Doctor of Medical Sciences, Professor of the Department of Family Medicine № 2, Avicenna Tajik State Medical University

Yodgorova Mayram Djumakhonovna, Candidate of Medical Sciences, Associate Professor of the Department of Family Medicine № 2, Avicenna Tajik State Medical University

Nosirova Matluba Pulatovna, Candidate of Medical Sciences, Associate Professor of the Department of Family Medicine № 2, Avicenna Tajik State Medical University

Conflicts of interest: No conflict

Address for correspondence:

Mamadzhanova Gulnora Sidikzhanovna

Candidate of Medical Sciences, Associate Professor of the Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: (+992) 915 990903

E-mail: gulnora.mamadjanova@gmail.com

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