MULTIMODAL APPROACH TO THE TREATMENT OF ESOPHAGEAL CANCER
1Department of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
2Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences,, Tomsk, Russian Federation
3Department of Oncology, Siberian State Medical University, Tomsk, Russian Federation
Objective: To study the effectiveness and tolerability of preoperative chemotherapy (CHT) in combination with radical surgery in patients with esophageal squamous cell carcinoma (ESCC) II-III stages
Methods: The results of the combined and surgical treatment of 43 patients with ESCC II-III stages are presented. The main group consisted of 22 patients who were assigned two courses of CHT before surgery (gemcitabine/cisplatin), followed by a radical surgery. The control group included 21 patients who received only surgical treatment.
Results: Preoperative CHT in one (4.5±4.6%) patient gave a complete regression of the tumor, incomplete regression was in ten (45.5±11.1%) and stabilization is established in nine (40.9±10.9%) patients. The therapy had satisfactory tolerability and low toxicity, most patients observed the restoration of a full enteral nutrition. Postoperative complications in both groups of observations developed in 18.2±8.6% and 23.8±9.5% respectively (p>0.05). Preoperative CHT in the combined treatment of ESCC II-III stages has significantly improved two-year relapse-free and overall survival (80,9±8,7% and 85,7±7,8%) compared to the control group (35.0±10.6% and 55.0±11.1%) (p<0.05).
Conclusions: The multimodal approach in the treatment of patients in II-III stages ESCC has pronounced damaging effect on the tumor and allows to significantly increase two-year relapse-free and overall survival rate compared to patients who have undergone only surgical treatment.
Keywords: Esophageal squamous cell carcinoma, combined treatment, preoperative chemotherapy, short-term and long-term results.
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Urmonov Umidzhon Butabekovich
, Postgraduate Student in the Department of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences SPIN code: 7150-7291
Dobrodeev Aleksey Yurievich
, Doctor of Medical Sciences, Leading Researcher in the Department of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences SPIN code: 5510-4043; ORCID ID: 0000-0002-2748-0644
Afanasyev Sergey Gennadievich
, Doctor of Medical Sciences, Full Professor, Head of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences SPIN code: 9206-3037; ORCID ID: 0000-0002-4701-0375
Avgustinovich Aleksandra Vladimirovna
, Researcher in the Department of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences SPIN code: 2952-6119; Author ID: 558788
Rodionov Evgeniy Olegovich
, Candidate of Medical Sciences, Junior Researcher in the Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Assistant of the Department of Oncology, Siberian State Medical University SPIN code: 7650-2129; Author ID: 805452
Conflict of interest: No conflict
Address for correspondence:
Urmonov Umidzhon Butabekovich
Postgraduate Student in the Department of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
634009, Russian Federation, Tomsk, Kooperativniy per., 5
Tel.: +7 (953) 9137175
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