ORIGINAL RESEARCH
Oncology
doi: 10.25005/2074-0581-2025-27-4-879-889
INCIDENCE OF MULTIPLE PRIMARY MALIGNANT NEOPLASMS IN SIBERIA AND THE FAR EAST

L.D. ZHUYKOVA1, L.V. PIKALOVA1, M.V. ZAVYALOVA1,2, E.L. CHOYNZONOV1,2, G.A. KONONOVA1, A.V. ZAVYALOV2

1Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
2Siberian State Medical University, Tomsk, Russian Federation

Objective: To investigate the occurrence of multiple primary malignant neoplasms (MPMNs) in Siberia and the Far East from 2011 to 2022.

Methods: The calculation and analysis of MPMN incidence were based on data collected from the Federal Statistical Observation Form No. 7, "Information on Malignant Neoplasms", which covers the Siberian Federal District (SFD) and the Far Eastern Federal District (FEFD). Additionally, data from the Tomsk region's population-based cancer registry were used.

Results: A statistically significant increase in MPMN incidence has been observed in the SFD (165.2%) and the FEFD (57.7%). An analysis of MPMN morbidity in the Tomsk region revealed the following characteristics: A predominance of metachronous tumors at 80.5%; 41.9% of tumors were diagnosed at stage I; in men, the most common types of cancer were: prostate cancer (18.4%), skin cancer (15.8%), colon cancer (14.2%), and lung cancer (13.0%); in women, the most common types were: skin tumors (19.7%), breast cancer (17.9%), colon cancer (13.2%), and lung cancer (7.1%). The rate of neglected MPMN (stage IV) was 20.1%, consistent with similar indicators for malignant neoplasms in general. The average age of patients was 70.5 years, with a higher proportion of women (54.6%), who were 5.5 years older than the average for the overall cohort of cancer patients.

Conclusion: There has been a significant increase in the incidence of MPMNs, while the rate of neglected diagnoses has stagnated. This highlights the need to study the epidemiological and clinical-morphological characteristics of MPMNs. Additionally, it is essential to develop and implement an algorithm for monitoring patients after antitumor treatment to facilitate the early diagnosis of MPMNs.

Keywords: Primary multiple malignant neoplasms, morbidity, oncological care, Siberian Federal District, Far Eastern Federal District, Tomsk region.

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References
  1. Sultanbaev AV, Menshikov KV, Musin ShI, Izmaylov AA, Menshikova IA, Sultanbaeva NI. Prediktory pervichno-mnozhestvennykh zlokachestvennykh novoobrazovaniy. Obzor literatury [Predictors of primary multiple malignancies. Literature review]. Kreativnaya khirurgiya i onkologiya. 2023;13(3):221-8. https://doi.org/10.24060/2076-3093-2023-13-3-221-228
  2. Kaprin AD, Starinskiy VV, Shakhzadova AO. Sostoyanie onkologicheskoy pomoshchi naseleniyu Rossii v 2022 godu [The state of cancer care for the population of Russia in 2022]. Moscow, RF: MNIOI im. P.A. Gertsena − filial FGBU «NMITs radiologii» Minzdrava Rossii; 2022. 239 р.
  3. Karamova DA, Kudinova AI, Tolstova AV, Saveliev VN. Issledovanie zabolevaemosti zlokachestvennymi novoobrazovaniyami lyogkikh [Study of the incidence of malignant neoplasms of the lungs]. Avitsenna. 2018;17:44-7.
  4. Stepanova YuA, Kalinin DV, Vishnevskiy VA. Pervichno-mnozhestvennye opukholi (obzor literatury) [Primary multiple tumors (literature review)]. Meditsinskaya vizualizatsiya. 2015;6:93-102.
  5. Agabekyan GO, Azizyan RI, Stelmakh DK. Osobennosti taktiki lecheniya pervichno-mnozhestvennogo ploskokletochnogo raka verkhnikh dykhatel'nykh i pishchevaritel'nykh putey [Peculiarities of treatment tactics for primary multiple squamous cell carcinoma of the upper respiratory and digestive tracts]. Zlokachestvennye opukholi. 2016;4:104-8. https://doi.org/10.18027/2224–5057– 2016–4s1–104–108
  6. Borisova TN, Ivanov SM, Breder VV, Laktionov KK, Tkachyov SI, Glebovskaya VV, i dr. Pervichno-mnozhestvennye zlokachestvennye opukholi lyogkikh. Dannye literatury i klinicheskie nablyudeniya [Primary multiple malignant tumors of the lungs. Literature data and clinical observations]. Voprosy onkologii. 2016;62(1):166-70.
  7. Ofitsial'nyy sait Federal'noy sluzhby gosudarstvennoy statistiki. Byulleten' «Chislennost' naseleniya Rossiiskoy Federatsii po polu i vozrastu» [Internet] (tsitirovano 24 yanvarya 2024) Dostupno po: https://rosstat.gov.ru/ compendium/document/13284 [Official website of the Federal State Statistics Service. Bulletin "Population of the Russian Federation by gender and age" [Internet] (cited 2024 January 24). Available from: https://rosstat.gov.ru/ compendium/document/13284].
  8. Multiple primary and Histology Coding Rules Manual (SEER). URL: https://seer. cancer.gov/tools/mphrules/download.html (01.12.2024)
  9. International rules for multiple primary cancers (ICD-0 third edition). Eur J Cancer Prev. 2005;14(4):307-8. https://doi.org/10.1097/00008469-200508000-00002
  10. Sedova TG. Aktinicheskiy keratoz – predictor razvitiya pervichnomnozhestvennogo sinkhronnogo ploskokletochnogo raka kozhi: opisanie klinicheskogo nablyudeniya [Actinic keratosis as a predictor of primary multiple synchronous squamous cell skin cancer: A clinical case]. Al'manakh klinicheskoy meditsiny. 2022;50(7):455-61. https://doi.org/10.18786/2072-0505-2022-50- 054
  11. Semionkin EI, Lukanin RV, Bragina IYu, Snegur SV, Yudina EA, Krotkov AR. Pervichno-mnozhestvennyy rak kishechnika [Primary-multiple bowel cancer]. Vestnik Natsional'nogo mediko-khirurgicheskogo tsentra im. N.I. Pirogova. 2023;18(2)139-42. https://doi.org/10.25881/20728255_2023_18_2_139
  12. Obukhovich RA, Tezhik AV, Aleshchik ICh. Rak gortani v sostave pervichnomnozhestvennykh opukholey [Laryngeal cancer as part of primary multiple tumors]. Otorinolaringologiya. Vostochnaya Evropa. 2023;13(S2):101-3.
  13. Kaprin AD, Starinskiy VV, Shakhzadova AO. Zlokachestvennye novoobrazovaniya v Rossii v 2022 godu (zabolevaemost' i smertnost') [Malignant neoplasms in Russia in 2022 (morbidity and mortality)]. Moscow, RF: MNIOI im. P.A. Gertsena − filial FGBU «NMITs radiologii» MinzdravaRossii; 2023. 275 p.
  14. Titov KS, Karpenko RV, Lebedev SS, Grekov DN, Yakusheva TA. Pervichnomnozhestvennye sinkhronnye opukholi: osobennosti diagnostiki i lecheniya [Multiple primary synchronous tumors: Features of modern diagnosis and treatment]. Onkologiya. Zhurnal im. P.A. Gertsena. 2024;13(1):63-9. https://doi. org/10.17116/onkolog20241301163

Authors' information:

Zhuykova Liliya Dmitrievna,
Doctor of Medical Sciences, Head of Epidemiology Laboratory, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Researcher ID: C-8293-2012
Scopus ID: 56626111900
ORCID ID: 0000-0003-3536-8473
SPIN: 3260-1308
Author ID: 633353
E-mail: zhuikovalili@mail.ru

Pikalova Lidiya Valentinovna,
Candidate of Medical Sciences, Researcher, Laboratory of Epidemiology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Researcher ID: E-5347-2017
Scopus ID: 57190937921
ORCID ID: 0000-0003-1453-2254
SPIN: 3631-4547
Author ID: 917980
E-mail: l.v.pikalova@tomonco.ru

Zavyalova Marina Viktorovna,
Doctor of Medical Sciences, Full Professor, Leading Researcher, General and Molecular Pathology Department, Cancer Research Institute, Tomsk National Research Medical Center; Head of Pathological Anatomy Department, Siberian State Medical University
Researcher ID: С-8580-2012
Scopus ID: 36711031100
ORCID ID: 0000-0001-9429-9813
SPIN: 1229-0323
Author ID: 323615
E-mail: zavyalova.mv@ssmu.ru

Choynzonov Evgeniy Lkhamawyrenovich,
Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Full Professor, Director of Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Head of the Department of Oncology, Siberian State Medical University
Researcher ID: P-1470-2014
Scopus ID: 6603352329
ORCID ID: 0000-0002-3651-0665
SPIN: 2240-8730
Author ID: 550195
E-mail: choynzonov@tnimc.ru

Kononova Galina Aleksandrovna,
Junior Researcher, Epidemiology Laboratory, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Researcher ID: GVU-3963-2022
Scopus ID: 57861019700
ORCID ID: 0000-0001-6010-6462
SPIN: 4784-3108
Author ID: 1104711
E-mail: kononovaga@onco.tnimc.ru

Zavyalov Aleksandr Vasilievich,
Graduate Student, Siberian State Medical University
ORCID ID: 0009-0009-0266-6707
SPIN: 8509-5156
Author ID: 1157261
E-mail: zavyalova.mv@ssmu.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Zhuykova Liliya Dmitrievna
Doctor of Medical Sciences, Head of Epidemiology Laboratory, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

634009, Russian Federation, Tomsk, Cooperativnyy per., 5

Tel.: +7 (3822) 282686

E-mail: zhuikovalili@mail.ru


This work is licensed under a Creative Commons Attribution 4.0 International License.

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