Surgery
doi: 10.25005/2074-0581-2019-21-4-655-660
IMPORTANCE OF LABORATORY PARAMETERS IN THE DIAGNOSTICS OF COMPLICATED LIVER ECHINOCOCCOSIS

Z.A. Azizzoda1, K.M. Kurbonov1, K.R. Ruziboyzoda1, N.A. Rasulov2, S.G. Ali-Zade1

1Department of Surgical Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Surgery, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Dushanbe, Republic of Tajikistan

Objective: To determine the role of laboratory parameters for the study of early diagnosis of liver echinococcosis (LE) complications.

Methods: Carried out the results of a study of 147 patients with complicated LE – suppuration of echinococcal cysts (n=50) and mechanical jaundice (n=97). As a result of a general blood analysis for diagnosing complications of LE were studied biochemical analyzes and indicators of endogenous intoxication.

Results: The results of the study showed that in patients with complicated LE – suppuration and mechanical jaundice, noticed an increase content of leukocytes in 67.3%, of eosinophils in 42.9% and accelerated ESR in 57.8% of cases. The leukocyte intoxication index (LII) in patients with suppurative echinococcal liver cysts was 4.3±0.06 units. In patients with mechanical jaundice, an increase in the activity of ASAT and ALAT was observed up to 52.4±0.07 and 64.3±0.05 IU/L, respectively. In addition, patients showed an increase in the level of urea (7.8±0.05 mmol/L) and creatinine (128.4±0.04 μmol/L). In severe cases of jaundice indicators of bilirubin exceeded 190 μmol/L, diene conjugates increased to 1.86±0.074 nmol/L, malondialdehyde to 8.15±0.4 μmol/L, and medium mass molecules to 0.5±0.04 c.u./L, procalcitonin – up to 5.6±0.04 ng/mL, C-reactive protein – up to 175.3±9.8 mg/L.

Conclusion: Some indicators of the general and biochemical analysis of blood, as well as indicators of endogenous intoxication, can be very informative for the early diagnosis of complications of liver echinococcosis and determine the functional state of the liver. Laboratory indicators of functional state of the liver and the common state of the patients helps to choose the most rational surgery tactics, and thereby reduce the percentage of postoperative complications and mortality among these severe categories of patients.

Keywords: Liver echinococcosis, complication, diagnosis, biochemical analyzes, endogenous intoxication.

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Authors' information:

Azizzoda Zubaydullo Abdullo
Candidate of Medical Sciences, PhD Doctoral Candidate, Department of Surgical Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-5127-7355
Author ID: 623089
SPIN: 8131-6832
E-mail: azizov-med76@mail.ru

Kurbonov Karimkhon Murodovich
Academician of the Academy of Medical Sciences of the Republic of Tajikistan, Doctor of Medical Sciences, Full Professor, Professor of the Department of Surgical Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-8100-9722
Author ID: 361766
SPIN: 7076-3716

Ruziboyzoda Kakhramon Ruziboy
Candidate of Medical Sciences, Assistant of the Department of Surgical Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-8381-0364
Author ID: 1005844
SPIN: 7343-3380
E-mail: dr.hero85@mail.ru

Rasulov Nazir Aminovich
Candidate of Medical Sciences, Head of the Department of Surgery, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan
ORCID ID: 0000-0003-3663-0592
E-mail: mahmadnazir@mail.ru

Ali-Zade Sukhrob Gaffarovich
Candidate of Medical Sciences, Assistant of the Department of Surgical Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-2456-7509
Researcher ID: B-6807-2019
Author ID: 258253
SPIN: 6854-5343
E-mail: suhrob_a@mail.ru

Information about support in the form of grants, equipment, medications

The work was carried out according to the plan of scientific research works of Avicenna Tajik State Medical University (state registration number – 0116TJ00592). The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Azizzoda Zubaydullo Abdullo
Candidate of Medical Sciences, PhD Doctoral Candidate, Department of Surgical Diseases № 1, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (987) 217177

E-mail: azizov-med76@mail.ru

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  3. INFLAMMATION AND SEPSIS BIOMARKERS IN DIAGNOSIS OF THE GENERALIZED PERITONITIS STAGE
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