Surgery
doi: 10.25005/2074-0581-2020-22-2-280-285
INFLAMMATION AND SEPSIS BIOMARKERS IN DIAGNOSIS OF THE GENERALIZED PERITONITIS STAGE

A.R. Saraev1, Sh.K. Nazarov1, S.G. Ali-Zade1, A.M. Saburova2

1Department of Surgical Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To assess the predictable role of inflammatory biomarkers in determining the stage of generalized peritonitis.

Methods: The study included 160 patients with generalized peritonitis. All patients were assigned to three groups depending on the stages of the peritonitis. Once, on the first day after the patient’s admission to the hospital, investigated the concentration of the main inflammation markers in the blood serum.

Results: The maximum levels of biomarkers were found in patients with septic shock (group 3). The lowest average value and minimum concentration were detected in patients with generalized peritonitis in the endogenous intoxication stage. The presepsin test has a high degree of sensitivity (96.2%) and acceptable specificity (90.9%). The test for procalcitonin showed less sensitivity and specificity – 91.9 and 87.9%, respectively. The values of sensitivity and specificity of C-reactive protein and interleukin-6 in our study are slightly lower: 90%, 81.9%, and 90.9%, 84.8%, respectively. A strong correlation between biomarkers and the stage of the disease is noted. In this case, the strongest relationship was found in prespepsin (r=0.9194).

Conclusion: A reliable relationship between the severity of the extent of peritonitis and the level of presepsin in the blood was found, which allows for effective use of its value in the diagnosis of abdominal sepsis. The use of the complex of biomarkers has a higher value. The results we have obtained indicate the prospect character of using the presepsin test in combination with other markers of inflammation in surgical practice.

Keywords: Generalized peritonitis, abdominal sepsis, biomarkers of sepsis, presepsin, prediction.

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Authors' information:

Saraev Alisher Rakhmatulloevich
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0001-9695-1924
Researcher ID: F-5504-2019
SPIN: 6911-9887,
Author ID: 849178
E-mail: dr.saraev@mail.ru

Nazarov Shokhin Kuvvatovich
Doctor of Medical Sciences, Full Professor, Head of the Department of Surgical Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0003-2099-2353
Researcher ID: C-4033-2019
SPIN: 1817-7089
Author ID: 845034
E-mail: shohin67@mail.ru

Ali-Zade Sukhrob Gaffarovich
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases № 1, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-2456-7509
Researcher ID: B-6807-2019
SPIN: 6854-5343
Author ID: 258253
E-mail: suhrob_a@mail.ru

Saburova Anna Mukhammadievna
Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University
ORCID ID: 0000-0002-2456-7509
SPIN: 9132-9748
Author ID: 425954
E-mail: n_hursand@mail.ru

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment

Conflicts of interest: No conflict

Address for correspondence:

Saraev Alisher Rakhmatulloevich
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases № 1, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel. : +992 (918) 650540

E-mail: dr.saraev@mail.ru

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