doi: 10.25005/2074-0581-2017-19-4-497-500

A.A. Usenova

Department of Surgical Diseases, International Higher School of Medicine, Bishkek, Kyrgyz Republic

Objective: To study the ethnic distribution features of the acute myeloid leukemia (AML) among children in Kyrgyzstan.

Methods: The study covers the period from 2006 to 2016 with the inclusion of all cases of AML. The calculation carried out on 1 million children according to the National Statistics Committee of the Kyrgyz Republic. For the investigated period, registered 121 cases of AML in children (age category from 0 to 14 years) in Kyrgyzstan.

Results: When comparing prevalence rates depending on the nationality, the highest numbers were in Kyrgyz-children with a value of 8.36 per 1 million population. The morbidity indicators in persons of Uzbek and Russian nationality were lower, that amounting to 6.2 and 4.29 per 1 million people respectively. Comparison of standardized incidence rates showed a similar pattern: for Kyrgyz, Uzbeks and Russians, they amounted to 2.59±0.06, 1.33±0.03 and 1.9±0.02, respectively.

Conclusion: The unevenness of AML incidence caused by different percentage ratios of ethnic groups on the territory of Kyrgyzstan, and the highest morbidity rates among Kyrgyz people are due to its greater number.

Keywords: Acute myeloblastic leukaemia, a standardized incidence rate.

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  1. Rudenko VV, Tanas AS. Popa AV. Epigenetika ostrogo mieloidnogo leykoza u detey i vzroslykh [Epigenetics of acute myeloid leukemia in children and adults]. Meditsinskaya genetika. 2017;16(4):9-18.
  2. Arora RS, Arora B. Acute leukemia in children: A review of a current Indian data. South Asian J Cancer. 2016;5(3):155-60.
  3. Estey EH. Acute myeloid leukemia: 2014 update on risk-stratification and management. Am J Hematol. 2014;89:1063-81
  4. Hakulinen T, Seppa K, Lambert PC. Choosing the relative survival method for cancer survival estimation. Eur J Cancer. 2011;47:2202-10.
  5. Irons RD, Chen Y, Wang X, Ryder J, Kerzic PJ. Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy relateddisease. Genes Chromosomes Cancer. 2013;52(10):887-94.
  6. Nakata K, Ito Y, Magadi W, Bonaventure A, Stiller CA, Katanoda K. et al. Childhood cancer incidence and survival in Japan and England: A populationbased study (1993-2010). Cancer Sci. 2018;109(2):422-34.
  7. Baade PD, Youlden DR, Valery PC, Hassall T, Ward L, Green AC, et al. Trends in incidence of childhood cancer in Australia, 1983-2006. Br J Cancer. 2010;102(3):620-6.
  8. Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia Net. Blood. 2010;115(3):453-74.
  9. Horton SJ, Huntly BJ. Recent advances in acute myeloid leukemia stem cell biology. Haematologica. 2012;97(7):966-9.
  10. Han S, Lee LM, Park SK, Lee JE, Ahn HS, Shin HY, et al. Genom-wide association study of childhood acute lymphoblastic leukemia in Korea. Leuk Res. 2010;34(10):1271-4.
  11. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277-300.
  12. Oksuzyan S, Crespi CM, Cocburn M, Mezei G, Vergara X, Kheifets L. Race ethnicity and the risk of childhood leukemia: a case-control study in California. J Epidemiol Community Health. 2015;69(8):795-802.
  13. Masetti R, Vendemini F, Zama D, Biagi C, Pession A, Locatelli F. Acute myeloid leukemia in infants: Biology and treatment. Front Pediatr. 2015;3:37. Available from: http://dx.doi.org/10.3389/fped.2015.00037.
  14. Sant M, Allemani C, Tereanu C, De Angelis R, Capocaccia R, Visser O, et al. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010;116(19):3724-34.
  15. Dzhunushaliev DD. Demograficheskie izmeneniya nemetskogo naseleniya v suverennom Kyrgyzstane [Demographic changes in the German population in sovereign Kyrgyzstan]. Vestnik KRSU. 2013;13(6):18-22.
  16. Rumyantsev PO, Saenko VA, Rumyantseva UV. Statisticheskie metody analiza v klinicheskoy praktike, chast’ I [Statistical methods of analysis in clinical practice, Part I]. Problemy endokrinologii. 2009;5:48-55.

Authors' information:

Usenova Asel Abdumomunovna, Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases of the International Higher School of Medicine

Conflicts of interest: No conflict

Address for correspondence:

Usenova Assel Abdumomovna

Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases of the International Higher School of Medicine

720054, Kyrgyzstan, Bishkek, str. Intergelpo, 1F

Tel.: (+996) 555 677866

E-mail: usenova@gmail.com

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