Traumatology and orthopedics

doi: 10.25005/2074-0581-2017-19-4-520-523
INVESTIGATION OF CALCIUM-PHOSPHORIC EXCHANGE IN WOMEN WITH THE MENOPAUSE STATE SUFFERING FROM OSTEOARTHROSIS AND CONCOMITANT OSTEOPENIC SYNDROME

A.S. Kaysinova1, A.B. Lepshokova1, T.B. Menshikova1, N.K. Akhkubekova1, L.A. Cherevashchenko1, R.M. Mallaeva2

1Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
2Federal State Budget Educational Institution of Higher Professional Education «Dagestan State Medical University» of the Ministry of Health of the Russian Federation, Makhachkala, Russia

Objective: To study changes in calcium-phosphorus metabolism, bone metabolism and mineral bone density in osteoarthritis with the concomitant osteopenic syndrome in women with the menopause state.

Methods: We examined 40 women in the state of menopause (50-60 years), patients with osteoarthrosis of the hip joints, with a duration of disease of 3-5 and more years (the main group), and 20 healthy women of the same age (control group).

Results: An increase (p<0.05) of the serum level of the C-terminal telopeptide of type I collagen, a marker of bone resorption, a predominance speed of bone resorption rate over bone formation, while no significant deviations in the level of phosphatemia and calcemia were observed with a tendency to decrease activity of alkaline phosphatase and the level of osteocalcin – markers of bone formation in serum. In addition, osteopenia has been noted in various parts of the skeleton: in the spine with a predominantly trabecular type of bone structure.

Conclusions: The revealed multiple correlation relationships of the main characteristic indicators of osteoarthrosis with markers of bone resorption once again testify the comorbidity of osteoarthritis with osteoporosis.

Keywords: Osteoarthritis, osteopenic syndrome, calcium-phosphorus metabolism, bone metabolism, menopause.

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Authors informations:

Kaysinova Agnessa Sardoevna, Doctor of Medical Sciences, Deputy Director for Curative Work, Pyatigorsk State Scientific Research Institute of Balneology

Lepshokova Amina Borisovna, Postgraduate student, Pyatigorsk Clinic of Pyatigorsk State Scientific Research Institute of Balneology

Menshikova Tatyana Borisovna, Candidate of Medical Sciences, Leading Researcher of the Scientific Department of the Revival Rheumatology, Pyatigorsk Clinic of the Pyatigorsk State Research Institute of Balneology

Akhkubekova Nelly Kaytmurzaevna, Doctor of Medical Sciences, Senior Researcher of the Scientific Department of the Physical and Rehabilitation Medicine, Pyatigorsk Clinic of the Pyatigorsk State Research Institute of Balneology

Cherevashchenko Lyubov Anatolievna, Doctor of Medical Sciences, Full Professor, Senior Researcher of Pyatigorsk Clinic of the Pyatigorsk State Research Institute of Balneology

Mallaeva Raziyat Mudunovna, Candidate of Medical Sciences, Assistant of the Department of Clinical Pharmacology of the Dagestan State Medical University

Address for correspondence:

Kaysinova Agnessa Sardoevna

Doctor of Medical Sciences, Deputy Director for Curative Work, Pyatigorsk State Scientific Research Institute of Balneology

357500, Russian Federation, Pyatigorsk, Kirova Ave., 30

Tel.: (+7) 879 3335766

E-mail: orgotdel@gniik.ru

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