PECULIARITIES OF DIAGNOSTICS AND COURSE OF UTERINE CERVICAL CANCER AMONG HIV-INFECTED WOMEN
1Department of Oncology, South Ural State Medical University, Chelyabinsk, Russian Federation
2Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, Republic of Kazakhstan
3Regional Oncological Dispensary of Akimat of the South Kazakhstan Region, Shymkent, Republic of Kazakhstan
Objective: To assess the clinical course of uterine cervical cancer (UCC) against the background of HIV infection and its complex diagnosis.
Methods: A retrospective analysis carried out to 847 outpatient cards of patients for the period 2016-2017. Of these, 17 were HIV-positive. Two groups were formed: group I – patients with UCC on the background of HIV, group II – patients with UCC without HIV. The mean age was 37.4±0.2 and 52.8±0.3 years, respectively. Stages of UCC in group I: IIB – 6 (35.5%), IIIA – 4 (23.5%), IIIB – 6 (35.5%), IVB – 1 (5.5%); in the II group: IB – 3 (15%), IIB – 10 (50%), IIIB – 6 (30%), IVB – 1 (5%). Distribution according to the histological structure in group I: squamous nonkeratinized cancer – 11 (68.75%), keratinizing – 1 (6.25%), adenocarcinoma – 4 (25%). In group II: squamous nonkeratinized cancer – 13 (65%), squamous keratinizing – 3 (15%), adenocarcinoma – 4 (2%). The groups were comparable in treatment methods: in both groups, chemoradiation therapy was used according to standard schemes.
Results: Indicators in the I group: lethality – 4 (23.5%), stabilization – 5 (23.5%), progression – 8 (53%); in the second group: lethality – 1 (5%), stabilization – 14 (70%), progression – 5 (25%).
Conclusions: UCC in the background of HIV infection occurs at an earlier age. The predominance of stage IIB disease and squamous nonkeratinized cancer in both groups was noted. Mortality within the first year, stabilization and progression in the I and II groups were 23.5%, 23.5%, 53% and 5%, 70%, 25%, respectively.
Keywords: Human immunodeficiency virus (HIV), uterine cervical cancer, lethality, stabilization, progressing.
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Bekhtereva Svetlana Aleksandrovna,
Candidate of Medical Sciences, Associate Professor of the Department of Oncology, South Ural State Medical University
Yaytsev Sergey Vasilievich,
Doctor of Medical Sciences, Full Professor, Head of the Department of Oncology, South Ural State Medical University
Akhetov Amir Amantaevich,
Doctor of Medical Sciences, Director, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan
Shanazarov Nasrulla Abdullaevich,
Doctor of Medical Sciences, Full Professor, Deputy Director for Science, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan
Asabaeva Rita Iskandarovna,
Postgraduate Student of the Department of Oncology, South Ural State Medical University; Doctor oncologist of the Regional Oncological Dispensary of the Akimat of the South Kazakhstan region
Conflict of interest: No conflict
Address for correspondence:
Shanazarov Nasrulla Abdullaevich
Doctor of Medical Sciences, Professor, Deputy Director for Science of the Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan
010000, Republic of Kazakhstan, Astana, str. E495, № 2
Tel.: (+7) 717 2708082
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