Neurology
doi: 10.25005/2074-0581-2019-21-1-60-65
COGNITIVE DYSFUNCTIONS IN PATIENTS OF MIDDLE, ELDERLY AND OLD AGE IN THE LONG-TERM PERIOD AFTER CHOLECYSTECTOMY

M.K. Gulov1, A.M. Safarzoda2

1Department of General Surgery № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2City Research Center for Resuscitation and Detoxification, Dushanbe, Republic of Tajikistan

Objective: To study the state of cognitive dysfunction in patients of middle, elderly and old age in the long-term period after cholecystectomy

Methods: A study conducted on the state of cognitive dysfunctions in 306 patients with cholelithiasis, operated on at the City Clinical Emergency Hospital for the period 2012 to 2017. Long-term results studied at 12 and 24 months after cholecystectomy. Depending on age, the subjects divided into 3 groups: middle, elderly, and old (senile) age. The study included a standardized neurological examination on a brief scale of neuropsychological testing, «Examination of mental status» and a quantitative assessment of the «Drawing watches» test; cognitive impairment determined by the performance of attention «The arrangement of numbers according to the method of Wexler». In addition, the following tests conducted distribution and switching of attention according to Schulte; selectivity of attention by Munsterberg; Bourdon correction method and intellectual liability assessment

Results: 26 (25.4%) middle-aged patients diagnosed with mild cognitive dysfunction. In 28 (27.4%) elderly patients, cognitive impairment characterized by the presence of a moderate degree of cognitive dysfunction. In 39 (38.2%) patients of senile age, cognitive impairment manifested by the inability to memorize new information, as well as to reproduce the information that was already available that however did not lead to social deadaptation.

Conclusion: Operative-anesthetic trauma has a negative impact on the state of cognitive functions in elderly and senile patients with a non-burdened neuropsychiatric history in the late postoperative period after cholecystectomy. The prevalence of cognitive impairment in the late postoperative period after cholecystectomy diagnosed in 27.4% of elderly patients and in 38.2% of old patients. The clinical picture of late postoperative cognitive dysfunction in the patients observed and expressed in a decrease in mental performance, attention, memory, distribution and switching of attention, concentration rate and accuracy, and intellectual liability, which was the cause of their social discomfort and reducing the quality of life.

Keywords: Age-related cognitive dysfunctions , cholelithiasis, cholecystectomy.

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Authors' information:

Gulov Mahmadshoh Kurbonalievich
Doctor of Medical Sciences, Full Professor, Professor of the Department of General Surgery № 1, Avicenna Tajik State Medical University

Safarzoda Abdullo Mumin
Candidate of Medical Sciences, Director of the City Research Center for Resuscitation and Detoxification

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment.

Conflicts of interest: No conflict

Address for correspondence:

Safarzoda Abdullo Mumin
Candidate of Medical Sciences, Director of the City Research Center for Resuscitation and Detoxification

734003, Republic of Tajikistan, Dushanbe, Sanoi str., 33

Tel.: +992 (985) 210400

E-mail: abdullo-1969@mail.ru

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