Pediatrics

doi: 10.25005/2074-0581-2019-21-2-269-273
SPA TREATMENT OF CHILDREN WITH ENVIRONMENTAL-BURDENED PYELONEPHRITIS ASSOCIATED WITH DISORDERS OF PURINE EXCHANGE

L.N. Shvedunova1, A.S. Kaysinova1, N.V. Efimenko1, S.V. Dyomina1, S.A. Pachin2,3, I.I. Gaydamaka2

1Pyatigorsk Research Institute of Resortology, Pyatigorsk, Russian Federation
2Stavropol State Medical University, Stavropol, Russian Federation
3Regional Sanatorium for Children with Parents «Hot Key», Pyatigorsk, Russian Federation

Objective: To study the effectiveness of the treatment on the basis of drinking mineral waters, carbon dioxide baths and rational pharmacotherapy in children with environmental burdened chronic pyelonephritis, associated with violations of purine exchange, in the conditions of the Zheleznovodsk resort.

Methods: Fifty children with chronic pyelonephritis with an environmental burdened anamnesis of 11-14 years were under observation. The method of simple randomization was formed two groups: control (25 people), which received traditionally accepted treatment at the Zheleznovodsk resort (dietary nutrition, therapeutic gymnastics, internal intake of the little mineralized mineral water of the Smirnov spring, carbon dioxide mineral baths), and the main one (25 people), where children received additional drug therapy with herbal medicine Canefron N. All patients were prescribed: ultrasound examination of the kidneys, clinical and biochemical blood and urine tests.

Results: Comparative analysis showed that children of main group had a reduction of pain and dysuric syndromes, and in control group pain syndrome by the end of treatment persisted in 8% of cases, slightly more often preserved dysurian (16%) and asthenonneurotic (16%) syndromes. In children of main group, there was a significant decrease in daily oxaluria (by 39.2%; р<0,01), an increase in the rate of glomerular filtration (by 11.93%), which was statistically significant in relation to the data in control group, where there was only a tendency to improve kidney function. According to the data of the long-term results in children of main group, the number of relapses decreased by 2.9 times (p<0.01), while in patients of control group there was only a tendency to decrease this indicator.

Conclusions: Comprehensive balneo- and drug therapy in children with environmental burdened pyelonephritis, associated with purine metabolism disorders, contribute to statistically significant to increase clinical effectiveness, ensures the long-term preservation of the achieved therapeutic effect.

Keywords: Children, environmental burdened pyelonephritis, mineral waters, resort treatment.

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Authors informations:

Shvedunova Larisa Nikolaevna , Doctor of Medical Sciences, Chief Scientist, Pyatigorsk Research Institute of Resortology ORCID ID: 0000-0002-5612-6732

Kaysinova Agnessa Sardoevna , Doctor of Medical Sciences, Deputy of General Director for Medical Work, Pyatigorsk Research Institute of Resortology SPIN: 6552-9684; ORCID ID: 000-003-1199-3303

Efimenko Natalia Viktorovna , Doctor of Medical Sciences, Deputy of General Director for Scientific Work, Pyatigorsk Research Institute of Resortology ORCID ID: 0000-0001-7005-8927

Dyomina Svetlana Vyacheslavovna , Senior Researcher, Pyatigorsk Research Institute of Resortology ORCID ID: 0000-0001-9905-898X

Pachin Sergey Aleksandrovich , Candidate of Medical Sciences, Chief Medical Officer, Regional Sanatorium for Children with Parents «Hot Key»; Assistant of the Department of Manual Therapy, Therapeutic Physical Training and Sports Medicine, Stavropol State Medical University ORCID ID: 0000-0002-5426-4621

Gaydamaka Ivan Ivanovich , Doctor of Medical Sciences, Full Professor, Head of the Department of Manual Therapy, Therapeutic Physical Training and Sports Medicine, Stavropol State Medical University ORCID ID: 0000-0003-1119-7825

Address for correspondence:

Kaysinova Agnessa Sardoevna
Doctor of Medical Sciences, Deputy of General Director for Medical Work, Pyatigorsk Research Institute of Resortology

357501, Russian Federation, Pyatigorsk, Kirov Ave., 30

Tel.: +7 (8793) 335766

E-mail: orgotdel@gniik.ru

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