Oncology
doi: 10.25005/2074-0581-2019-21-3-420-425
COMBINED TREATMENT OF PATIENTS WITH NON-SMALL CELL LUNG CANCER WITH PERSONALIZED PRESCRIPTION OF ADJUVANT CHEMOTHERAPY

E.O. Rodionov1,2, S.V. Miller1, L.A. Efteev1, S.A. Tuzikov1,2, M.M. Tsyganov3, I.V. Deryusheva3, N.V. Litvyakov3,4, V.A. Markovich1, U.B. Urmonov5

1Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
2Department of Oncology, Siberian State Medical University, Tomsk, Russian Federation
3Oncovirology Laboratory, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
4Institute of Biology, Ecology, Soil Science, Agriculture and Forestry, National Research Tomsk State University, Tomsk, Russian Federation
5Department of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation

Objective: To study the long-term results of the combined treatment of non-small cell lung cancer (NSCLC) using pre-surgery chemotherapy, radical surgery and personalized adjuvant chemotherapy based on the level of monoresistance genes.

Methods: Four-year results of treatment of 72 patients of NSCLC II-III stage were analyzed. All patients underwent 2 courses of neoadjuvant chemotherapy (vinorelbine/carboplatin) and surgical treatment. Personalized adjuvant chemotherapy based on the levels of expression of monoresistance genes АВСС5, RRM1, TYMS, TOP1, TOP2α, TUBB3, BRCA1, and ERCC1 was performed in the main group (n=35). Three courses of adjuvant chemotherapy (vinorelbine/carboplatin) were performed in the control group (n=37).

Results: In the main group the progression of the disease was observed in 14 out of 35, and in the control group – in 21 out of 37 patients. Relapsefree survival (RFS) in the main group was 60.0% (95% CI: 43.6-74.5), in the control group – 43.2% (95% CI: 28.7-59.1); Log-Rank test χ2 =3,071, р=0,080; RR=1,808 (95% CI: 0.918-3.561). The median RFS in the control group was 27 months (95% CI: 5.7-48.3). The overall survival rate in the main group was 77.1% (95% CI: 61.0-87.9), in the control group – 54.1% (95% CI: 38.4-69.0); Log-Rank test χ2 =2,813, p=0.094; RR=2,024 (95% CI: 0,870-4,709).

Conclusion: The developed method of personalized prescribing adjuvant chemotherapy to patients with NSCLC based on the molecular genetic characteristics of the tumor improves relapse-free and overall survival.

Keywords: Non-small cell lung cancer , monoresistance genes , personalized chemotherapy.

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Authors' information:

Rodionov Evgeniy Olegovich
Candidate of Medical Sciences, Senior Researcher, Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Assistant, Department of Oncology, Siberian State Medical University
SCOPUS: 57189622130
Researcher ID: B-7280-2017
ORCID ID: 0000-0003-4980-8986
Author ID: 805452
SPIN: 7650-2129 E-mail: rodionov_eo@oncology.tomsk.ru

Miller Sergey Viktorovich
Doctor of Medical Sciences, Leading Researcher, Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
SCOPUS: 56525429400
Researcher ID: C-8970-2012
ORCID ID: 0000-0002-5365-9840
SPIN: 6510-9849
Author ID: 558789
E-mail: miller_sv@sibmail.com

Efteev Leonid Aleksandrovich
Junior Researcher, Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
ORCID ID: 0000-0002-9054-0742
SPIN: 3474-4654
E-mail: efteyco@rambler.ru

Tuzikov Sergey Aleksandrovich
Doctor of Medical Sciences, Full Professor, Head of the Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center Russian Academy of Sciences; Professor of the Department of Oncology, Siberian State Medical University
SCOPUS: 6507842873
Researcher ID: D-1176-2012
ORCID ID: 0000-0002-0884-1838
Author ID: 455003
SPIN: 5662-6431
E-mail: TuzikovSA@oncology.tomsk.ru

Tsyganov Matvey Mikhaylovich
Candidate of Biological Sciences, Senior Researcher, Oncovirology Laboratory, Cancer Research Institute, Tomsk National Medical Research Center of the Russian Academy of Sciences
SCOPUS: 55366377400
Researcher ID: A-7212-2014
ORCID ID: 0000-0001-7419-4512
SPIN: 1253-0240
E-mail: TsyganovMM@yandex.ru

Deryusheva Irina Valeryevna
Junior Researcher, Oncovirology Laboratory, Cancer Research Institute, Tomsk National Medical Center of the Russian Academy of Sciences
Scopus: 57194535404
Researcher ID: q-5607-2017
ORCID ID: 0000-0002-9568-3371
SPIN: 5560-6131
E-mail: Irkin_097@mail.ru

Litvyakov Nikolay Vasilyevich
Doctor of Biological Sciences, Head of the Oncovirology Laboratory, Cancer Research Institute, Tomsk National Medical Center of Russia Academy of Sciences; Senior Researcher, National Research Tomsk State University
SCOPUS: 6506850698
Researcher ID: C-3263-2012
ORCID ID: 0000-0002-0714-8927
SPIN: 2546-0181
E-mail: nvlitv72@yandex.ru

Markovich Vitaliy Aleksandrovich
Junior Researcher, Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center of Russian Academy of Sciences
ORCID ID: 0000-0002-7599-1211
SPIN: 2954-8330
Author ID: 968514
E-mail: vitalii.markovich.87@mail.ru

Urmonov Umidzhon Butabekovich
Postgraduate Student, Department of Abdominal Oncology, Cancer Research Institute, Tomsk National Research Medical Center of Russian Academy of Sciences
ORCID ID: 0000-0003-2804-4227
SPIN: 7150-7291
E-mail: Urmonovub@oncology.tomsk.ru

Information about support in the form of grants, equipment, medications

The research was carried out with the grant support of the Foundation for the Advancement of Small Businesses in Science and Technology within the framework of the Youth Science and Innovation Competition program (contract (agreement) № 11783 SI/2017 of July 3, 2017).

Conflicts of interest: No conflict

Address for correspondence:

Rodionov Evgeniy Olegovich
Candidate of Medical Sciences, Senior Researcher, Department of Thoracic Oncology, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Assistant, Department of Oncology, Siberian State Medical University

634009, Russian Federation, Tomsk, lane Kooperativniy, 5

Tel.: +7 (952) 8894663

E-mail: rodionov_eo@oncology.tomsk.ru

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