Neurosurgery
doi: 10.25005/2074-0581-2025-27-4-1056-1062
INTRACRANIAL SOLITARY FIBROUS TUMOR: CASE REPORT AND A LITERATURE REVIEW
Department of Neurosurgery, National Medical and Surgical Center named after N.I. Pirogov, Moscow, Russian Federation
Intracranial solitary fibrous tumors (SFTs) are rare primary central nervous system neoplasms. Currently, the neurosurgical management of patients with SFTs relies on limited literature and primarily involves total tumor resection. The necessity of radiation therapy in the postoperative period remains a topic of debate. Symptoms associated with this disease are nonspecific and are primarily dependent on the tumor's location and size.
This article presents a case report of surgical treatment of a patient with an SFT located at the right petrous apex and tentorium, extending into the middle and posterior cranial fossae. The surgery was performed using an infratemporal fossa approach combined with intraoperative neuronavigation. After internal decompression, significant bleeding was observed both from the tumor tissue itself and the altered underlying bone. Postoperative brain MRI revealed that a near-total resection of the tumor (96.4%) was achieved while prioritizing the avoidance of potential hemorrhagic complications related to the removal of the difficult-to-reach cavernous sinus extension of the tumor. After the surgery, the patient showed improvement in her neurological and overall clinical status. Thus, the treatment method employed has proven effective and can be recommended for the management of SFTs of the central nervous system.
Keywords: Brain, solitary fibrous tumor, meningeal tumor, microsurgical treatment, clinical case.
References
- Klemperer P, Coleman BR. Primary neoplasms of the pleura. A report of five cases.Am J Ind Med. 1992;22(1):1-31. https://doi.org/10.1002/ajim.4700220103
- Stout AP, Murray MR. Hemangiopericytoma a vascular tumor featuring Zimmermann’s pericytes. Ann Surg. 1942;116:26-32.
- Salmaggi A, Domina E, Piparo M, Billo P, Schembari S, Spena G, et al. A retrospective multicenter study of WHO 2021 classification – Diagnosed solitary fibrous tumor of the CNS in a population from Lombardy, Italy. Neurol Sci. 2025;46(2):961-7. https://doi.org/10.1007/s10072-024-07837-6
- Jo VY, Fletcher CD. WHO classification of soft tissue tumours: An update based on the 2013 (4th) edition. Pathology. 2014;46(2):95-104. https://doi.org/10.1097/ PAT.0000000000000050
- Kozlov NA, Tsygankova AV, Abdullaev AG. Solitary fibrous tumor: Features of the clinical course, radiation and laboratory diagnostics, therapy: A review. Journal of Modern Oncology. 2021;23(4):655-9. https://doi.org/10.26442/18151434.20 21.4.201069
- Ozaniak A, Hladik P, Lischke R, Strizova Z. Diagnostic challenges and treatment options in patients with solitary fibrous tumor: A single-center observational study. Front Surg. 2022;9:952463. https://doi.org/10.3389/fsurg.2022.952463
- Ajouz H, Sohail AH, Hashmi H, Aguilar MM, Daoui S, Tembelis M, et al. Surgical considerations in the resection of solitary fibrous tumors of the pleura. J Cardiothorac Surg. 2023;18(1):79. https://doi.org/10.1186/s13019-023-02168-7
- Krengli M, Cena T, Zilli T, Jereczek-Fossa BA, De Bari B, et al. Radiotherapy in the treatment of extracranial hemangiopericytoma/solitary fibrous tumor: Study from the Rare Cancer Network. Radiother Oncol. 2020;144:114-20. https://doi. org/10.1016/j.radonc.2019.11.011
- González-Vargas PM, Thenier-Villa JL, Sanromán Álvarez P, Combo AS, Felix LC, Galarraga Campoverde RA, et al. Hemangiopericytoma/solitary fibrous tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: A 10-year analysis of a heterogeneous series in a single tertiary center. Neurocirugia (Engl Ed). 2020;31(1):14-23. https://doi. org/10.1016/j.neucir.2019.06.001
- Chen N, Slater K. Solitary fibrous tumour of the liver-report on metastasis and local recurrence of a malignant case and review of literature. World J Surg Oncol. 2017;15(1):27. https://doi.org/10.1186/s12957-017-1102-y
- Carneiro SS, Scheithauer BW, Nascimento AG, Hirose T, Davis DH. Solitary fibrous tumor of the meninges: A lesion distinct from fibrous meningioma. A clinicopathologic and immunohistochemical study. Am J Clin Pathol. 1996;106(2):217-24. https://doi.org/10.1093/ajcp/106.2.217
- Halperin EC, Wazer DE, Perez SA, Luther WB. Perez and Brady’s principles and practice of radiation oncology. Seventh edition. Philadelphia, USA: Wolters Kluwer; 2018. 3347 p.
- Wang K, Mei F, Wu S, Tan Z. Hemangiopericytoma: Incidence, treatment, and prognosis analysis based on SEER database. Biomed Res Int. 2020;2020:2468320. https://doi.org/10.1155/2020/2468320
- Liu F, Cai B, Du Y, Huang Y. Diagnosis and treatment of hemangiopericytoma in the central nervous system. J Cancer Res Ther. 2018;14(7):1578-82. https://doi. org/10.4103/jcrt.JCRT_210_18
- Kinslow CJ, Rae AI, Kumar P, McKhann GM, Sisti MB, Bruce JN, et al. Risk stratification for management of solitary fibrous tumor/hemangiopericytoma of the central nervous system. Cancers (Basel). 2023;15(3):876. https://doi. org/10.3390/cancers15030876
- Davanzo B, Emerson RE, Lisy M, Koniaris LG, Kays JK. Solitary fibrous tumor. Transl Gastroenterol Hepatol. 2018;3:94. https://doi.org/10.21037/tgh.2018.11.02
- Martin-Broto J, Mondaza-Hernandez JL, Moura DS, Hindi N. A comprehensive review on solitary fibrous tumor: New insights for new horizons. Cancers (Basel). 2021;13(12):2913. https://doi.org/10.3390/cancers13122913
Authors' information:
Chernyshyov Roman Sergeevich,
Clinical Resident, Department of Neurosurgery, National Medical and Surgical Center named after N.I. Pirogov
ORCID ID: 0000-0003-2414-2807
E-mail: r.chernyshyov@gmail.com
Dimertsev Aleksey Vladimirovich,
Candidate of Medical Sciences, Assistant Professor of the Department of Neurosurgery, National Medical and Surgical Center named after N.I. Pirogov
ORCID ID: 0000-0003-4578-2205
SPIN: 4989-0310
Author ID: 1127179
E-mail: dimertsev@gmail.com
Zuev Andrey Aleksandrovich,
Doctor of Medical Sciences, Full Professor, Head of the Department of Neurosurgery, National Medical and Surgical Center named after N.I. Pirogov
Scopus ID: 26424155600
ORCID ID: 0000-0003-2974-1462
SPIN: 9377-4574
Author ID: 213123
E-mail: mosbrain@gmail.com
Information about support in the form of grants, equipment, medications
The research was carried out in accordance with the research plan of National Medical and Surgical Center named after N.I. Pirogov (state registration number – 1027700077668). The authors did not receive financial support from manufacturers of medicines and medical equipment
Conflicts of interest: No conflict
Address for correspondence:
Chernyshyov Roman Sergeevich
Clinical Resident, Department of Neurosurgery, National Medical and Surgical Center named after N.I. Pirogov
105203, Russian Federation, Moscow, Nizhnyaya Pervomayskaya str., 70
Tel.: +7 (913) 4656376
E-mail: r.chernyshyov@gmail.com
This work is licensed under a Creative Commons Attribution 4.0 International License.
Materials on the topic:
- MINIMALLY INVASIVE ENDOSCOPIC TREATMENT OF GLOSSOPHARYNGEAL NEURALGIA USING A BURR-HOLE TECHNIQUE: CASE SERIES
- INTRACRANIAL HEMORRHAGE: EPIDEMIOLOGY, PREVENTION, ETIOLOGY, CLINICAL FEATURES AND PROGNOSIS
- BIOMECHANICAL COMPARISON OF TRANSPEDICULAR FIXATION METHODS UNDER ROTATIONAL LOADING FOR OPTIMIZING SURGERY ON THE THORACOLUMBAR JUNCTION OF THE SPINE
- MICROSURGICAL TREATMENT OF DISTAL POSTERIOR INFERIOR CEREBELLAR ARTERY ANEURYSM DURING THE COLD PERIOD AFTER SPONTANEOUS INTRACRANIAL HEMORRHAGE: A CASE REPORT
- EXTERNAL VENTRICULAR DRAINAGE FOR MALIGNANT ISCHEMIC STROKE: A CASE REPORT
- IMMUNE RESISTANCE VIA A PD-1/PD-L1 MECHANISM IN GLIOBLASTOMA
- DECOMPRESSIVE HEMICRANIECTOMY AFTER UNSUCCESSFUL INTRAVENOUS THROMBOLYSIS OF MALIGNANT MIDDLE CEREBRAL ARTERY INFARCTION: A CASE REPORT
- INTRADURAL HYPOGLOSSAL SCHWANNOMA WITHOUT HYPOGLOSSAL PARALYSIS AND TONGUE ATROPHY: A CASE STUDY AND LITERATURE REVIEW
- SUPPLEMENTARY MOTOR AREA AND CLINICAL PICTURE OF ITS LESION
- A CASE OF SUCCESSFUL OPEN SURGICAL TREATMENT OF A GIANT ANEURISM OF THE SUPRACLINOID SEGMENT OF THE INTERNAL CAROTID ARTERY