Hormonal and metabolic concept of pathogenesis prostate diseases

I.A. Tyuzikov, S.Yu. Kalinchenko

Metabolic syndrome – a complex concept that includes a number of metabolic factors which are in pathogenetic relationship (abdominal obesity, dyslipidemia, endothelial dysfunction, atherosclerosis, hypertension, type 2 diabetes mellitus, systemic chronic inflammation, and in men – low levels of testosterone) . It is closely related to the pathogenesis of prostate diseases, and their pathophysiological relations are presented in this review. Urologists and endocrinologists should be aware of the metabolic syndrome role in the prostate diseases genesis, as a new understanding of the pathogenesis of urological disorders and their pathogenetic treatment and prevention are possible only through interdisciplinary approach.

Keywords: metabolic syndrome, prostate, type 2 diabetes, obesity, hypogonadism, benign prostatic hyperplasia, chronic prostatitis.

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