Pediatrics

doi: 10.25005/2074-0581-2019-21-1-71-76
LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND

Z.A. Badalova1, J.S. Dodkhoev1, A.M. Saburova2

1Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the content of superoxide dismutase (SOD) and malonic dialdehyde (MDA) in the blood of children by the influence of heightened radiation background.

Methods: The levels of MDA and SOD in the blood were determined in 20 newborns and in 60 to 3-5 years old children living in the area of high radiation background. The control group included 80 children and newborns living in areas with a natural radiation background. The content of MDA was determined by the method of I.D. Stalnaya, and the level of SOD – by the method of reduction of nitro-blue tetrazole in serum.

Results: Levels of MDA in children living in conditions with a natural radiation background, were: newborns – 0.065±0.003 μmol/l; 3 years old children – 0.073±0.003 μmol/l; children 4 years old – 0.065±0.003 μmol/l; children 5 years old – 0.060±0.002 μmol/l. At the same time, in children living in conditions of heightened radiation background, the level of MDA was higher, with the greatest level among newborns – 0.879±0.025 μmol/l. In children 3, 4 and 5 years, this values were 0.301±0.025; 0.338±0.027 and 0.671±0.049 μmol/l, accordingly. The content of SOD in children living in conditions with a normal natural radiation background was as follows: newborns – 12.7±0.2 c. u./l; children 3 years old – 13.1±0.1 c. u./l; children 4 years old – 13.4±0.1 c. u./l; children 5 years old – 13.1±0.1 c. u./l. At the same time, in children living in conditions of heightened radiation background, considerably low levels of SOD were detected: newborns – 11.5±0.2 c. u./l; children 3 years old – 11.7±0.1 c. u./l; children 4 years old – 11.5±0.1 c. u./l; children 5 years old – 11.5±0.1 c. u./l.

Conclusions: The results of conducted research revealed the presence of oxidative stress and imbalance of the pro- and antioxidant systems in children living in conditions of heightened radiation background

Keywords: Superoxide dismutase, malonic dialdehyde, radiation, children.

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Authors informations:

Badalova Zebo Abdulkhayrovna , Postgraduate Student, Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

Dodkhoev Jamshed Saidboboevich , Doctor of Medical Sciences, Professor of the Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

Saburova Anna Mukhammadievna , Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University

Address for correspondence:

Badalova Zebo Abdulkhayrovna
Postgraduate Student, Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (988) 532116

E-mail: z_bad@mail.ru

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