Pediatrics

doi: 10.25005/2074-0581-2019-21-1-71-76
LEVELS OF MALONIC DIALDEHYDE AND SUPEROXIDE DISMUTASE IN CHILDREN FROM A ZONE WITH HEIGHTENED RADIATION BACKGROUND

Z.A. Badalova1, J.S. Dodkhoev1, A.M. Saburova2

1Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
2Department of Biochemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan

Objective: To study the content of superoxide dismutase (SOD) and malonic dialdehyde (MDA) in the blood of children by the influence of heightened radiation background.

Methods: The levels of MDA and SOD in the blood were determined in 20 newborns and in 60 to 3-5 years old children living in the area of high radiation background. The control group included 80 children and newborns living in areas with a natural radiation background. The content of MDA was determined by the method of I.D. Stalnaya, and the level of SOD – by the method of reduction of nitro-blue tetrazole in serum.

Results: Levels of MDA in children living in conditions with a natural radiation background, were: newborns – 0.065±0.003 μmol/l; 3 years old children – 0.073±0.003 μmol/l; children 4 years old – 0.065±0.003 μmol/l; children 5 years old – 0.060±0.002 μmol/l. At the same time, in children living in conditions of heightened radiation background, the level of MDA was higher, with the greatest level among newborns – 0.879±0.025 μmol/l. In children 3, 4 and 5 years, this values were 0.301±0.025; 0.338±0.027 and 0.671±0.049 μmol/l, accordingly. The content of SOD in children living in conditions with a normal natural radiation background was as follows: newborns – 12.7±0.2 c. u./l; children 3 years old – 13.1±0.1 c. u./l; children 4 years old – 13.4±0.1 c. u./l; children 5 years old – 13.1±0.1 c. u./l. At the same time, in children living in conditions of heightened radiation background, considerably low levels of SOD were detected: newborns – 11.5±0.2 c. u./l; children 3 years old – 11.7±0.1 c. u./l; children 4 years old – 11.5±0.1 c. u./l; children 5 years old – 11.5±0.1 c. u./l.

Conclusion: The results of conducted research revealed the presence of oxidative stress and imbalance of the pro- and antioxidant systems in children living in conditions of heightened radiation background

Keywords: Superoxide dismutase, malonic dialdehyde, radiation, children.

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Author information:


Badalova Zebo Abdulkhayrovna
Postgraduate Student, Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

Dodkhoev Jamshed Saidboboevich
Doctor of Medical Sciences, Professor of the Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

Saburova Anna Mukhammadievna
Doctor of Biological Sciences, Full Professor, Professor of the Department of Biochemistry, Avicenna Tajik State Medical University

Information about support in the form of grants, equipment, medications

The authors did not receive financial support from manufacturers of medicines and medical equipment.

Conflicts of interest: No conflict

Address for correspondence:


Badalova Zebo Abdulkhayrovna
Postgraduate Student, Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University

734003, Republic of Tajikistan, Dushanbe, Rudaki Ave., 139

Tel.: +992 (988) 532116

E-mail: z_bad@mail.ru

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