Comparative analysis of clinicalpathogenetic and neurophysiological features of various infectious genesis forms of polyneuropathy

R.A. Rakhmonov, F.A. Khodjayev, F.T. Mirzoyev, M.H. Kahorova

This paper presents research results of clinical-pathogenetic and neurophysiological features of different polyneuropathy infectious genesis. The study showed that patients with chronic inflammatory demyelinating and leprosy polyneuropathies are marked motor and sensory disturbances such as upper and lower extremities, while in diphtheria and typhoid polyneuropathies disease process prevails in the lower extremities. The study of indicators of lipid peroxidation (LPO) and antioxidant defense system (ADS) in patients with a variety of polyneuropathy, found that the greatest intensification of lipid peroxidation occurs in patients with leprous polyneuropathy (LP), followed by chronic inflammatory demyelinating polyneuropathy (CIDP), and in patients with diphtheria (DifPN) and typhoid (TPN) polyneuropathy changes were less revealed. The antioxidant defense system (superoxide dismutase and indicators of ascorbic acid) reduced most in patients with LP and CIDP, and according to stimulating electroneurographya ENG in patients with LP, CIDP and TPN revealed signs of axonal - demyelinating lesions, while DifPN - axonal type of nerve damage fiber

Keywords: infectious polyneuropathy disturbance of gematoneural barrier, axonal - demyelinating lesion, malon dialdehyde, superoxide dismutase.

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