Summary
doi: 10.25005/2074-0581-2013-15-1-115-120
Intestinal transdifferentiation of the gastric mucosa in precancerous lesions
Vinnitsa National Medical University named after NI Pirogov, Ukraine
* FSBI «Research Institute of Human Morphology» RAMS;SBEI HPE «Russian National Research Medical University named after NIPirogov «Russian Ministry of Health, Moscow, Russia
The authors examined 98 patients who were referred to endoscopy department and study rooms of Vinnitsa region to clarify the clinical diagnosis.
The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies is carried out. Found that CDX2 by activating its own promoter is able to fix the intestinal phenotype of the gastric mucosa (GM)cells. The loss of CDX2 expression in nuclei of metaplastic epithelium can serve as an early marker of GM malignancy
Keywords: chronic atrophic gastritis, gastric mucosa, intestinal metaplasia of gastric mucosa, malignancy.
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