Optimization of diagnosis of herpes zoster by infrared spectroscopy

M.T. Mirzoeva, M.S. Isayeva, T.Sh. Shukurov

Chair of Dermatology and Venereology of Avicenna TSMU

The results of diagnosis of 40 patients with of herpes zoster (HZ) by the molecular infrared spectroscopyis presented in the paper. The infrared spectroscopy method of investigation in contrast to the known methods of diagnosis offers the ability to diagnose all forms of HZ.

In preherpetic stage is observedshifting of the maximum (νmax) frequency, appeared band in the frequency of 1600 – 1200 sm-1 and take place the redistribution of intensity. In bullosa form of HZ is observed splitting a weak band of methyl groups to the doublet, and for the bands 1640 and 1550 cm- 1 is a slight change in the intensity ratio and the shift νmax band to 65 cm-1 into the low-frequency side. In a generalized form is observed decreasing ratio of the intensities of OH - and methyl groups, as smoothing a very weak bands which are manifested in the frequency range 1450 - 1050 cm- 1. In ophthalmoherpes ininfrared spectra of patients are observed a slight shift νmax and diminishing ratio of the intensity of bands 3295 and 2910 cm- 1.

This method is highly efficient because for registration of infrared spectrum is enough only one drop of blood plasma, and it does not require expensive chemical agent to register infrared spectrum and diagnosis requires only 30 minutes.

Keywords: herpes zoster, infrared spectroscopy.

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