Features of immune disorders in acute phase of traumatic brain injury

E.M. Mamytova

Kyrgyz State Medical Academy named afterIK Akhunbaev, Bishkek, Kyrgyzstan

The results of a study of cytokine status and changes in cellular immunity in 28 patients with traumatic brain injury (TBI) of moderate severity in acute period are presented in article.

The level of serum cytokines (interleukins IL-1β; IL-4; IL-6; α-TNF, γ-IFN) differs from that of healthy donors. Statistically significant isdefinedtheincreasing ofpro-inflammatory cytokines levels IL-1β (2,3 fold, 7,6±1,0 pg/ml), α-TNF (2,5-times), IL-6 (5,9 times 13,7±2,3 pg/ml), γ-IFN (6,9 times), and antiinflammatory cytokine IL-4 (2,6 times to 3,4±1,0 pg/l).

Study of cellular immunity in acute TBI showed levelsreduction of T-lymphocytes (CD3+) positive cells and T-helper cells, while the level of killer cells, CD8 lymphocytes and B-lymphocytes was increased.

In primary moderately severe TBI occurs suppression of T-cell immunity that manifested by reduced bloodlevels of T-helper cells and CD3-positive cells and the activation of B-cell level and natural-killer lymphocyte subpopulations.

Keywords: brain injury , cytokines, lymphocyte subpopulations .

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