Summary

doi: 10.25005/2074-0581-2014-16-3-72-76
Features of kidney lesions on patients with acute myeloid leukemia during chemotherapy

M.P. Ganieva, O.D. Rakhmonova, A.T. Shamsov, G.B. Khojieva

Chair of Internal Medicine №3 Avicenna TSMU

Under observation was 253 patients with acute myeloid leukemia in a variety of clinical and hematologic diseases terms. All patients were divided into 3 groups: I group (n=99) – patients at the onset of disease, II group (n=80) – in clinical remission, III group (n=76) – in term of myelotoxic agranulocytosis.

In all groups a changes, indicating infiltrative kidney lasions are marked. Moreover, in periods of myelotoxic agranulocytosis and clinical remission the indicants were more pronounced.

Course of the disease at different stages of chemotherapy, in most cases (69%), followed by renal impairment of varying severity, ranging from violations of the filtration rate up to oliguric acute renal failure, which requires the use of renal replacement therapy.

Keywords: acute myeloid leukemia, chemotherapy, renal replacement therapy, myelotoxic agranulocytosis.

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