Chronic hepatitis «C» in Tajikistan

S.M. Azimova, A.D. Dustov, R.A. Tursunov*

SI «Institute of Gastroenterology» the Ministry of Health and Social Protection of the Republic of Tajikistan
*Avicenna Tajik State Medical University

This paper presents an assessment of the epidemiological, clinical and biochemical features of chronic hepatitis C (CHC, HCV) in Tajikistan.

During the period 2006-2010 surveyed 3102 people from different regions of the Republic of Tajikistan, including: patients with chronic hepatitis C (CHC, HCV) – 440 patients with HIV, injecting drug users (IDUs) – 276 health workers – 412, primary donor – 1436, pregnant women – 538.

The most important feature of epidemiological registered incidence of HCV in Tajikistan is a viral infection during the latent (asymptomatic) currency among different population groups. HCV infection rates among primary blood donors and pregnant women is 6,6% and 6,0%, respectively, reflecting the complex epidemiological situation.

Clinical manifestations of chronic hepatitis C often occur in patients infected with the introduction of injecting drug use and much less – as a result of medical procedures.

The prevalence of HCV genotypes varies depending on the tract infection: genotypes 1a and 1b are often determined in groups of patients infected by sexual contact; genotype 2 – in group with unknown transmission factor, health workers and confirmed as a result of medical procedures; genotype 3a – often in groups of IDUs and patients infected through tattooing.

IgM antibodies to core-antigen and IgG class to the NS5-antigen were significantly more deter-mined in the sera of HCV patients with positive detection of RNA HCV.

Keywords: chronic hepatitis C (CHC, HCV), HIV infection, genotype HCV, RNA HCV, injecting drug users (IDUs).

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