Disorders of endothelial function indices in patients with dermatitis

M.H. Khojaeva, M.S. Tabarov, M.S. Isayeva*, Z.M. Toshtemirova

Chair of Pathophysiology; *Dermatology and venereology Avicenna TSMU

The authors studied the content of desquamated endothelial cells, von Willebrand factor, fibrinogen and platelets in 60 patients with various forms of dermatitis (contact, allergic, toxicodermatosis). One of the pathogeneticelements of dermatitis is a violation of the entirety of vascular endothelium, as indicated by a significant increase ofdesquamated endothelial cells, von Willebrand factor, fibrinogen and platelet counts in peripheral blood.

Thus intoxicodermatosis and allergic dermatitis the level of desquamated endothelial cells was 13,8±0,4×104 /L and 11,1±0,6×104 /L, respectively; von Willebrand factor – 134,3±3,4% and 130,3±3,9%, respectively; fibrinogen – 2,8±0,1 g/ L and 2,8±0,1 g/L, respectively; and platelets -278,3±6,1×106 /L and 263,3±4,9×106 /L, respectively. Studies have shown the effectiveness of basic therapy for dermatitis, as indicated by decreasingthe level desquamated endothelial cells in blood level (4,0±0,2×104 /L), von Willebrand factor (121,4±2,0%), fibrinogen (2,8±0,1 g/L), and platelets (217,2±4,9×106 /L), and also the regression of eruption elements.

Keywords: dermatitis, endothelial dysfunction, von Willebrand factor.

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